
Keywords: selfish gene
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Gene-drive-mediated extinction is thwarted by population structure and evolution of sib matingJ. J. Bull, C. H. Remien and S. M. Krone, Evolution Medicine and Public Health, 2019:66-81. 2019.![]() Genetic engineering combined with CRISPR technology has developed to the point that gene drives can, in theory, be engineered to cause extinction in countless species. Success of extinction programs now rests on the possibility of resistance evolution, which is largely unknown. ... Keywords: conversion, DNA, elements, gene drive ecology, gene drive evolution, gene drive genetics, gene drive natural, homing endonuclease, ins, intein, outcrossed sex, outs, pathway, population invasion, saccharomyces-cerevisiae, selfish gene, site-specific endonuclease, system, yeast |
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Adaptation for horizontal transfer in a homing endonucleaseKoufopanou, VG, M. R.; Burt, A., Molecular Biology and Evolution, 19:239-246. 2002.![]() Selfish genes of no function other than self-propagation are susceptible to degeneration if they become fixed in a population. and regular transfer to new species may be the only means for their long-term persistence. To test this idea we surveyed 24 species of yeast for VDE, a ... Keywords: conversion, DNA, elements, gene drive ecology, gene drive evolution, gene drive genetics, gene drive natural, homing endonuclease, ins, intein, outcrossed sex, outs, pathway, population invasion, saccharomyces-cerevisiae, selfish gene, site-specific endonuclease, system, yeast |
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Outcrossed sex allows a selfish gene to invade yeast populationsGoddard, MRG, D.; Burt, A., Proceedings of the Royal Society B-Biological Sciences, 268:2537-2542. 2001.![]() Homing endonuclease genes (HEGs) in eukaryotes are optional genes that have no obvious effect on host phenotype except for causing chromosomes not containing a cop), of the gene to be cut, thus causing them to be inherited at a greater than Mendelian rate via gene conversion. ... Keywords: conversion, DNA, elements, gene drive ecology, gene drive evolution, gene drive genetics, gene drive natural, homing endonuclease, ins, intein, outcrossed sex, outs, pathway, population invasion, saccharomyces-cerevisiae, selfish gene, site-specific endonuclease, system, yeast |

Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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