Keywords: Selfish genes
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How Selfish Genes Succeed: Critical Insights Uncovered About Dangerous DNASTOWERS INSTITUTE FOR MEDICAL RESEARCH, SciTechDaily, 2022.
New findings from the Stowers Institute for Medical Research uncover critical insights about how a dangerous selfish gene—considered to be a parasitic portion of DNA—functions and survives. Understanding this dynamic is a valuable resource for the broader community studying ... |
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Selfish genes and sexual selection: the impact of genomic parasites on host reproductionN. Wedell, Journal of Zoology, 311:1-12. 2020.Selfish genetic elements (SGEs) such as replicating mobile elements, segregation distorters and maternally inherited endosymbionts, bias their transmission success relative to the rest of the genome to increase in representation in subsequent generations. As such, they generate ... |
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Evolutionary simulations of Z-linked suppression gene drivesL. Holman, Proceedings of the Royal Society B-Biological Sciences, 286:1-9. 2019.
Synthetic gene drives may soon be used to suppress or eliminate populations of disease vectors, pathogens, invasive species, and agricultural pests. Recent proposals have focused on using Z-linked gene drives to control species with ZW sex determination, which include ... |
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Spatial structure undermines parasite suppression by gene drive cargoBull, JJR, Christopher H.; Gomulkiewicz, Richard; Krone, Stephen M., PeerJ, 7:e7921. 2019.
Gene drives may be used in two ways to curtail vectored diseases. Both involve engineering the drive to spread in the vector population. One approach uses the drive to directly depress vector numbers, possibly to extinction. The other approach leaves intact the vector population ... |
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Genetic villains: Killer meiotic driversBravo Núñez, MAN, Nicole L.; Zanders, Sarah E., Trends in Genetics, 34:424-433. 2018.
Unbiased allele transmission into progeny is a fundamental genetic concept canonized as Mendel’s Law of Segregation. Not all alleles, however, abide by the law. Killer meiotic drivers are ultra-selfish DNA sequences that are transmitted into more than half (sometimes all) of ... |
