siRNAs - GeneConvene Virtual Institute

Keywords: siRNAs

	Mosquitoes genetically modified to be resistant to Zika Staff, Lab+Life Scientist, 2021. Researchers have wrestled with different strategies for controlling the spread of Zika virus, which is transmitted to humans from female mosquito bites. One approach, which has been approved by the US Environmental Protection Agency, will see more than 750 million genetically ... Keywords: Aedes aegypti, antiviral, arbovirus, Cas9, CRISPR, Gene drive, immunity, RNAi, siRNAs, transformation, transgenesis, vector, yellow-fever mosquito, Zika virus
	Genetically-modified mosquitoes key to stopping Zika virus spread University of Missouri, Medical Xpress, 2021. Alexander Franz, an associate professor in the MU College of Veterinary Medicine, collaborated with researchers at Colorado State University by using CRISPR gene-editing technology to produce mosquitoes that are unable to replicate Zika virus and therefore cannot infect a human ... Keywords: Aedes aegypti, antiviral, arbovirus, Cas9, CRISPR, Gene drive, immunity, RNAi, siRNAs, transformation, transgenesis, vector, yellow-fever mosquito, Zika virus
	The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic Aedes aegypti A. E. Williams, I. Sanchez-Vargas, W. R. Reid, J. Y. Lin, A. W. E. Franz and K. E. Olson, Viruses, 12:18. 2020. We used CRISPR/Cas9 to re-target a previously characterized locus (Chr2:321382225) and engineered mosquitoes expressing an inverted repeat (IR) dsRNA against the NS3/4A region of the ZIKV genome. Small RNA analysis revealed that the IR effector triggered the mosquito's siRNA ... Keywords: Aedes aegypti, antiviral, arbovirus, Cas9, CRISPR, Gene drive, immunity, RNAi, siRNAs, transformation, transgenesis, vector, yellow-fever mosquito, Zika virus