Keywords: site-directed mutagenesis
Degeneration and domestication of a selfish gene in yeast: Molecular evolution versus site-directed mutagenesisKoufopanou, VB, A., Molecular Biology and Evolution, 22:1535-1538. 2005.
VDE is a homing endonuclease gene in yeasts with an unusual evolutionary history including horizontal transmission, degeneration, and domestication into the mating-type switching locus HO. We investigate here the effects of these features on its molecular evolution. In addition, ...
Keywords: cleavage, DNA-binding, elements, family, gene drive evolution, gene drive genetics, gene drive natural, HEG, ho endonuclease, homing endonucleases, identification, intein, molecular evolution, plants, recognition, Saccharomycetaceae, scei homing endonuclease, sequence, site-directed mutagenesis, VDE
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National Institutes of Health