Keywords: somatic gene conversion

New genetic copycatchers detect efficient and precise CRISPR editing in a living organism

UNIVERSITY OF CALIFORNIA - SAN DIEGO,  UNIVERSITY OF CALIFORNIA - SAN DIEGO,  2021.
Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques. Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of ...
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CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion

Z. Li, N. Marcel, S. Devkota, A. Auradkar, S. M. Hedrick, V. M. Gantz and E. Bier,  Nature Communications,  12:2625. 2021.
CRISPR-based active genetic elements, or gene-drives, copied via homology-directed repair (HDR) in the germline, are transmitted to progeny at super-Mendelian frequencies. Active genetic elements also can generate widespread somatic mutations, but the genetic basis for such ...
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