Keywords: stephensi
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Wolbachia 16S rRNA haplotypes detected in wild Anopheles stephensi in eastern EthiopiaE. Waymire, S. Duddu, S. Yared, D. Getachew, D. Dengela, S. R. Bordenstein, M. Balkew, S. Zohdy, S. R. Irish and T. E. Carter, Parasites and Vectors, 15:178. 2022.
About two out of three Ethiopians are at risk of malaria, a disease caused by the parasites Plasmodium falciparum and Plasmodium vivax. Anopheles stephensi, an invasive vector typically found in South Asia and the Middle East, was recently found to be distributed across eastern ... |
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Cas9-mediated maternal-effect and derived resistance alleles in a gene-drive strain of the African malaria vector mosquito, Anopheles gambiaeR. Carballar-Lejarazú, T. Tushar, T. B. Pham and A. A. James, Genetics, 2022.
CRISPR/Cas9 technologies are important tools for the development of gene-drive systems to modify mosquito vector populations to control the transmission of pathogens that cause diseases such as malaria. However, one of the challenges for current Cas9-based drive systems is their ... |
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Evaluation of anti-malaria potency of wild and genetically modified Enterobacter cloacae expressing effector proteins in Anopheles stephensiH. Dehghan, S. H. Mosa-Kazemi, B. Yakhchali, N. Maleki-Ravasan, H. Vatandoost and M. A. Oshaghi, Parasites and Vectors, 15:63. 2022.
Malaria is one of the most lethal infectious diseases in tropical and subtropical areas of the world. Paratransgenesis using symbiotic bacteria offers a sustainable and environmentally friendly strategy to combat this disease. In the study reported here, we evaluated the ... |
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Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoesV. Bottino-Rojas, I. Ferreira, R. D. Nunes, X. Feng, T. B. Pham, A. Kelsey, R. Carballar-Lejarazú, V. Gantz, P. L. Oliveira and A. A. James, Insect Biochemistry and Molecular Biology, 103720. 2022.
Insect ommochrome biosynthesis pathways metabolize tryptophan to generate eye-color pigments and naturally occurring alleles of pathway genes are useful phenotypic markers in transgenesis studies. Pleiotropic effects of mutations in some genes exert a load on both survival and ... |
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Detailed genome map of malaria vectorThe Hindu, Aspirant World, 2021.
In order to engineer advanced forms of defence against malaria transmission, including targeted CRISPR and gene drive–based strategies, scientists require intricate knowledge of the genomes of vector mosquitoes. CRISPR technology is a gene-editing tool which allows ... |
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Researchers Unveil Detailed Genome of Invasive Malaria MosquitoM. Aguilera, UC San Diego News Center, 2021.
Mosquito-transmitted malaria remains the number one worldwide killer among vector-borne diseases, claiming more than 400,000 human lives in 2019. In order to engineer advanced forms of defense against malaria transmission, including targeted CRISPR and gene drive-based ... |
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Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assemblyM. Chakraborty, A. Ramaiah, A. Adolfi, P. Halas, B. Kaduskar, L. T. Ngo, S. Jayaprasad, K. Paul, S. Whadgar, S. Srinivasan, S. Subramani, E. Bier, A. A. James and J. J. Emerson, BMC Biology, 19:28. 2021.
The mosquito Anopheles stephensi is a vector of urban malaria in Asia that recently invaded Africa. Studying the genetic basis of vectorial capacity and engineering genetic interventions are both impeded by limitations of a vector’s genome assembly. The existing assemblies of ... |
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Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensiA. Adolfi, V. M. Gantz, N. Jasinskiene, H.-F. Lee, K. Hwang, E. A. Bulger, A. Ramaiah, J. B. Bennett, G. Terradas, J. J. Emerson, J. M. Marshall, E. Bier and A. A. James, bioRxiv, 2020.08.02.233056. 2020.
We developed the first recoded gene-drive rescue system for population modification in the malaria vector, Anopheles stephensi, that relieves the load in females caused by integration of the drive into the kynurenine hydroxylase gene by rescuing its function. Non-functional ... |
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A synthetic male-specific sterilization system using the mammalian pro-apoptotic factor in a malaria vector mosquitoD. S. Yamamoto, M. Sumitani, K. Kasashima, H. Sezutsu, H. Matsuoka and H. Kato, Scientific Reports, 9:11. 2019.
We produced a transgenic mosquito line that expresses mouse Bax under the control of this testis-specific promoter. Transgenic mosquito males exhibited aberrant testes without functional sperm and complete sterility, whereas transgenic females maintained normal fecundity. Despite ... |
