Keywords: synthetic gene drive

Allele Sails: launching traits and fates into wild populations with Mendelian DNA sequence modifiers

Michelle L. Johnson, Bruce A. Hay, Maciej Maselko,  bioRxiv,  2024.
Population-scale genome editing can be used to alter the composition or fate of wild populations. One approach to achieving these aims utilizes a synthetic gene drive element—a multi-gene cassette—to bring about an increase in the frequency of an existing allele. However, the ...
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The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive

Clancy D. Lawler, Ana Karla Parra Nuñez, Natalia Hernandes, Soumitra Bhide, Isabelle Lohrey, Simon Baxter, Charles Robin,  bioRxiv,  2024.
A synthetic gene drive that targets haplolethal genes on the X-chromosome can skew the sex ratio towards males. Like an ‘X-shredder’ it does not involve ‘homing’ and that has advantages including the reduction of gene drive resistance allele formation. We examine this ...
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Genetic pest management and the background genetics of release strains

P. T. Leftwich, L. G. Spurgin, T. Harvey-Samuel, C. J. E. Thomas, L. C. Paladino, M. P. Edgington and L. Alphey,  Philosophical Transactions of the Royal Society B: Biological Sciences,  376:20190805. 2020.
We discuss issues around strain selection and the potential consequences of such introgression. We conclude that such introgression is probably harmless in almost all circumstances, and could, in theory, provide specific additional benefits to the release programme. We outline ...
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Genetically Engineered Fish: Potential Impacts on Aquaculture, Biodiversity, and the Environment

R. A. Dunham and B. Su,  GMOs: Implications for Biodiversity Conservation and Ecological Processes,  2020.
Studies on transgenic fish for the aquaculture industry have focused on improving growth rates, enhancing disease resistance, altering body composition, acting as biological factories for medical proteins, and even altering temperature tolerance and coloration. The future impact ...
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Fruit fly breakthrough puts killer mozzies on notice

V. Tressider,  The Lighthouse,  2020.
A new designer fruit fly paves the way for scientists to replace disease-carrying mosquitoes with harmless, genetically modified versions, says Macquarie University researcher Dr Maciej Maselko.
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Meet Cosmo, the gene-edited Crispr calf

S. D. McClain,  Capital Press,  2020.
Cosmo was the grand finale of a series of experiments to create a line of genome-edited cattle tailored for the beef industry. He was designed to produce 75% male offspring.
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Species Extinction & the Case for a Global Moratorium on Gene Drives

M. Imken,  ARC,  2020.
One million species are currently threatened with extinction, and humanity faces the challenge of stopping the sixth mass extinction in the history of our planet. Yet a new technology called Gene Drive enables human beings to reprogram wild species by genetic engineering and to ...
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