Keywords: synthetic lethality
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypesC. Douglas, V. Maciulyte, J. Zohren, D. M. Snell, S. K. Mahadevaiah, O. A. Ojarikre, P. J. I. Ellis and J. M. A. Turner, Nature Communications, 12:6926. 2021.
Animals are essential genetic tools in scientific research and global resources in agriculture. In both arenas, a single sex is often required in surplus. The ethical and financial burden of producing and culling animals of the undesired sex is considerable. Using the mouse as a ...
Keywords: Cas 9, CRISPR, driving X, driving y, gene drive synthetic, mouse, sex-ratio distorter, synthetic lethality
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