Keywords: tet off

Engineered expression of the invertebrate-specific scorpion toxin AaHIT reduces adult longevity and female fecundity in the diamondback moth Plutella xylostella

T. Harvey-Samuel, X. Xu, E. Lovett, T. Dafa'alla, A. Walker, V. C. Norman, R. Carter, J. Teal, L. Akilan, P. T. Leftwich, C. M. Reitmayer, H. A. Siddiqui and L. Alphey,  Pest Management Science,  2021.
To increase the flexibility of future genetic pest management systems in the diamondback moth, we aimed to assess the use of a non-cell-autonomous, invertebrate-specific, neurotoxic effector ? the scorpion toxin AaHIT. This AaHIT effector was designed to be secreted by ...
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Genetic breakdown of a Tet-off conditional lethality system for insect population control

Y. Zhao, M. F. Schetelig and A. M. Handler,  Nature Communications,  11:3095. 2020.
Genetically modified conditional lethal strains have been created to improve the control of insect pest populations damaging to human health and agriculture. However, understanding the potential for the genetic breakdown of lethality systems by rare spontaneous mutations, or ...
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