Keywords: tethered drive
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Experimental demonstration of tethered gene drive systems for confined population modification or suppressionM. Metzloff, E. Yang, S. Dhole, A. G. Clark, P. W. Messer and J. Champer, BMC Biol, 20:119. 2022.
BACKGROUND: Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This could represent a substantial ... |
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Experimental demonstration of tethered gene drive systems for confined population modification or suppressionM. Metzloff, E. Yang, S. Dhole, A. G. Clark, P. W. Messer and J. Champer, bioRxiv, 2021.05.29.446308. 2022.
Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This could represent a substantial sociopolitical ... |
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Experimental demonstration of tethered gene drive systems for confined population modification or suppressionM. Metzloff, E. Yang, S. Dhole, A. G. Clark, P. W. Messer and J. Champer, bioRxiv, 2021.05.29.446308. 2021.
Tethered drive systems, in which a locally confined gene drive provides the CRISPR nuclease needed for a homing drive, could provide a solution to this problem, offering the power of a homing drive and confinement of the supporting drive. Here, we demonstrate the engineering of a ... |
