Keywords: ticks

Wolbachia Impacts Anaplasma Infection in Ixodes scapularis Tick Cells

K. M. Skinner, J. Underwood, A. Ghosh, A. S. Oliva Chavez and C. L. Brelsfoard,  International Journal of Environmental Research and Public Health,  19. 2022.
The specific interactions of members of tick bacterial microbiota and their effects on pathogen transmission remains relatively unexplored. Here, we introduced a novel Wolbachia infection type into Ixodes scapularis tick cells and examined the antipathogenic effects on the ...
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First ever gene-edited ticks offer new weapons against Lyme disease

N. Lavars,  New Atlas,  2022.
Gene editing in ticks had been thought to be impossible until now, and with good reason. Tick embryos are very tricky to inject because the egg that contains them has a tough layer on the outside, high pressure levels inside, and is also coated in a waxy layer the mothers create ...
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Cas9-Mediated Gene-Editing in the Black-Legged Tick, Ixodes Scapularis, by Embryo Injection and ReMOT Control.

A. a. P. Sharma, Michael N. and Reyes, Jeremiah B. and Chana, Randeep and Yim, Won C. and Heu, Chan C. and Kim, Donghun and Chaverra-Rodriguez, Duverney and Rasgon, Jason L. and Harrell, Robert A. and Nuss, Andrew B. and Gulia-Nuss, Monika,,  Cell Reports,  2021.
Despite their capacity to acquire and pass on an array of debilitating pathogens, research on ticks has lagged behind other arthropod vectors, such as mosquitoes, largely because of a lack of genetic and molecular tools. CRISPR-Cas9 is transforming non-model organism research; ...
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Genetic Manipulation of Ticks: A Paradigm Shift in Tick and Tick-Borne Diseases Research

A. Nuss, A. Sharma and M. Gulia-Nuss,  Frontiers in Cellular and Infection Microbiology,  11:7. 2021.
Ticks are obligate hematophagous arthropods that are distributed worldwide and are one of the most important vectors of pathogens affecting humans and animals. Despite the growing burden of tick-borne diseases, research on ticks has lagged behind other arthropod vectors, such as ...
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