Keywords: transgenesis

The $11million wasp to end (hopefully) all wasps

Kieran Chisnall,  Stuff,  2024.
A new project to eradicate wasps, which cost the country millions of dollars, has begun in Dunedin. The key to that $11million project would be a genetically altered wasp, capable of destroying wasps colonies from the inside. Professor Peter Dearden, Genomics Aotearoa ...
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Maxizyme-mediated suppression of chikungunya virus replication and transmission in transgenic Aedes aegypti mosquitoes

Mishra P, Balaraman V, Fraser Jr. M,  Frontiers in Microbiology,  14. 2024.
Chikungunya virus (CHIKV) is an emerging mosquito-borne pathogen of significant public health importance. There are currently no prophylactic vaccines or therapeutics available to control CHIKV. One approach to arbovirus control that has been proposed is the replacement of ...
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Sustainable Food Production: The Contribution of Genome Editing in Livestock

A. Menchaca,  Sustainability,  13. 2021.
This article is focused on the scope and perspectives for the application of this technology, which includes improving production traits, enhancing animal welfare through adaptation and resilience, conferring resistance to infectious diseases, and suppressing pests and invasive ...
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femaleless Controls Sex Determination and Dosage Compensation Pathways in Females of Anopheles Mosquitoes

E. Krzywinska, L. Ferretti, J. Li, J.-C. Li, C.-H. Chen and J. Krzywinski,  Current Biology,  31:1084-1091.e4. 2021.
Here we show that in the African malaria mosquito Anopheles gambiae, a gene, which likely arose in the Anopheles lineage and which we call femaleless (fle), controls sex determination in females by regulating splicing of dsx and fruitless (fru; another terminal gene within a ...
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The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic Aedes aegypti

A. E. Williams, I. Sanchez-Vargas, W. R. Reid, J. Y. Lin, A. W. E. Franz and K. E. Olson,  Viruses,  12:18. 2020.
We used CRISPR/Cas9 to re-target a previously characterized locus (Chr2:321382225) and engineered mosquitoes expressing an inverted repeat (IR) dsRNA against the NS3/4A region of the ZIKV genome. Small RNA analysis revealed that the IR effector triggered the mosquito's siRNA ...
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Development of genetic control strategies for insect pests using CRISPR/Cas9 Développement de méthodes de lutte génétique contre de l’insecte nuisible basé sur le system CRISPR/Cas9

E. Green,  Université de Strasbourg,  2019.
nsect pest control remains an important economic, environmental, and public health challenge. CRISPR/Cas9 gene drive (GD) is a novel genetic control strategy. GDs are genetic systems that can rapidly invade a population. This manuscript presents my efforts to develop gene drives ...
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