Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populationsH. M. Sánchez C, J. B. Bennett, S. L. Wu, G. Rašić, O. S. Akbari and J. M. Marshall, BMC Biology, 18:50. 2020.
Here, we model hypothetical releases of two recently engineered threshold-dependent gene drive systems—reciprocal chromosomal translocations and a form of toxin-antidote-based underdominance known as UDMEL—to explore their ability to be confined and remediated.
Keywords: containment, gene drive models, gene drive synthetic, mosquitoes, reciprocal, translocation, UDMEL, underdominance