Keywords: transmission ratio distortion

Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line

D. Arends, S. Kärst, S. Heise, P. Korkuc, D. Hesse and G. A. Brockmann,  Genetics,  2021.
While direct additive and dominance effects on complex traits have been mapped repeatedly, additional genetic factors contributing to the heterogeneity of complex traits have been scarcely investigated. To assess genetic background effects, we investigated transmission ratio ...
Keywords: , , , , ,

Patterns and mechanisms of sex ratio distortion in the Collaborative Cross mouse mapping population

B. A. Haines, F. Barradale and B. L. Dumont,  Genetics,  219:iyab136. 2021.
In species with single-locus, chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative ...
Keywords: , , , , ,

Patterns and Mechanisms of Sex Ratio Distortion in the Collaborative Cross Mouse Mapping Population

B. A. Haines, F. Barradale and B. L. Dumont,  bioRxiv,  2021.
In species with single-locus chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative ...
Keywords: , , , , ,

First evidence of deviation from Mendelian proportions in a conservation programme

C. E. Grueber, K. A. Farquharson, B. R. Wright, G. P. Wallis, C. J. Hogg and K. Belov,  Molecular Ecology,  13. 2021.
Classic Mendelian inheritance is the bedrock of population genetics and underpins pedigree-based management of animal populations. However, assumptions of Mendelian inheritance might not be upheld in conservation breeding programmes if early viability selection occurs, even when ...
Keywords: , , , , ,

Widespread haploid-biased gene expression enables sperm-level natural selection

K. Bhutani, K. Stansifer, S. Ticau, L. Bojic, A.-C. Villani, J. Slisz, C. M. Cremers, C. Roy, J. Donovan, B. Fiske and R. C. Friedman,  Science,  eabb1723. 2021.
Here, we show that a large class of mammalian genes are not completely shared across these bridges. We term these genes “genoinformative markers” (GIMs) and show that a subset can act as selfish genetic elements that spread alleles unevenly through murine, bovine, and human ...
Keywords: , , , , ,

Whole-genome resequencing reveals loci with allelic transmission ratio distortion in F1 chicken population

P. Ren, F. Deng, S. Chen, J. Ran, J. Li, L. Yin, Y. Wang, H. Yin, Q. Zhu and Y. Liu,  Molecular Genetics and Genomics,  2021.
In this study, whole-genome resequencing technology was applied to reveal TRD loci in chicken by constructing a full-sib F1 hybrid population. Through the whole-genome resequencing data of two parents (30 ×) and 38 offspring (5 ×), we detected a total of 2850 TRD SNPs ...
Keywords: , , , , ,

Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages

J. F. Hughes, H. Skaletsky, T. Pyntikova, N. Koutseva, T. Raudsepp, L. G. Brown, D. W. Bellott, T.-J. Cho, S. Dugan-Rocha, Z. Khan, C. Kremitzki, C. Fronick, T. A. Graves-Lindsay, L. Fulton, W. C. Warren, R. K. Wilson, E. Owens, J. E. Womack, W. J. Murphy,  Genome Research,  2020.
Here, we provide evidence that suppression of X–Y crossing-over unleashed a second dynamic: selfish X–Y arms races that reshaped the sex chromosomes in mammals as different as cattle, mice, and men. Using super-resolution sequencing, we explore the Y Chromosome of Bos taurus ...
Keywords: , , , , ,

The bull Y chromosome has evolved to bully its way into gametes

Whitehead Institute for Biomedical Research,  Phys Org,  2020.
In a new study, published Nov. 18 in the journal Genome Research, scientists in the lab of Whitehead Institute Member David Page present the first ever full, high-resolution sequence of the Y chromosome of a Hereford bull. The research, more than a decade in the making, suggests ...
Keywords: , , , , ,

Maternal Transmission Ratio Distortion in Two Iberian Pig Varieties

M. Vazquez-Gomez, M. M. de Hijas-Villalba, L. Varona, N. Ibanez-Escriche, J. P. Rosas, S. Negro, J. L. Noguera and J. Casellas,  Genes,  11:16. 2020.
Although TRD can be a confounding factor in genetic mapping studies, this phenomenon remains mostly unknown in pigs, particularly in traditional breeds (i.e., the Iberian pig). We aimed to describe the maternal TRD prevalence and its genomic distribution in two Iberian varieties. ...
Keywords: , , , , ,