UDMEL Archives • GeneConvene Virtual Institute

Keywords: UDMEL

Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations

H. M. Sánchez C, J. B. Bennett, S. L. Wu, G. Rašić, O. S. Akbari and J. M. Marshall, BMC Biology, 18:50. 2020.

Here, we model hypothetical releases of two recently engineered threshold-dependent gene drive systems—reciprocal chromosomal translocations and a form of toxin-antidote-based underdominance known as UDMEL—to explore their ability to be confined and remediated.
Keywords: dengue, engineered translocations, Gene drive, gene drive genetics, gene drive synthetic, insects, malaria, mosquito, public acceptance, self-propagating, selfish genetic element, UDMEL, unbreakable, underdominance, vector control

Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila

Buchman, ABI, Tobin; Marshall, John M.; Akbari, Omar S.; Hay, Bruce A., ACS Synthetic Biology, 7:1359-1370. 2018.

Replacement of wild insect populations with transgene-bearing individuals unable to transmit disease or survive under specific environmental conditions using gene drive provides a self-perpetuating method of disease prevention. Mechanisms that require the gene drive element and ...
Keywords: dengue, engineered translocations, Gene drive, gene drive genetics, gene drive synthetic, insects, malaria, mosquito, public acceptance, self-propagating, selfish genetic element, UDMEL, unbreakable, underdominance, vector control