
Keywords: vertebrates
![]() |
Gene Drive: Past, Present and Future Roads to Vertebrate BiocontrolG. R. McFarlane, C. B. A. Whitelaw and S. G. Lillico, Applied Biosciences, 2:52-70. 2023.![]() Scientists have long sought a technology to humanely control populations of damaging invasive pests in a species-specific manner. Gene drive technology could see this become a reality. This review charts the twists and turns on the road to developing gene drives in vertebrates. ... Keywords: fertility control, Gene-silencing, genetic biocontrol, interfering RNA, RNAi, toxicant, vertebrates |
![]() |
Progress Toward Zygotic and Germline Gene Drives in MiceC. Pfitzner, M. A. White, S. G. Piltz, M. Scherer, F. Adikusuma, J. N. Hughes and P. Q. Thomas, The CRISPR Journal, 3:388-397. 2020.![]() Here, we investigated the efficiency of CRISPR-Cas9-based gene drives in Mus musculus by constructing "split drive" systems where gRNA expression occurs on a separate chromosome to Cas9, which is under the control of either a zygotic (CAG) or germline (Vasa) promoter. Keywords: fertility control, Gene-silencing, genetic biocontrol, interfering RNA, RNAi, toxicant, vertebrates |
![]() |
Development of zygotic and germline gene drives in miceC. Pfitzner, J. N. Hughes, M. A. White, M. Scherer, S. G. Piltz and P. Q. Thomas, bioRxiv, 2020.![]() Here we investigated the efficiency of CRISPR/Cas9-based gene drives in Mus musculus by constructing "split drive" systems with Cas9 under the control of zygotic (CAG) or germline (Vasa) promoters. Keywords: fertility control, Gene-silencing, genetic biocontrol, interfering RNA, RNAi, toxicant, vertebrates |
![]() |
RNAi: Applications in Vertebrate Pest ManagementK. E. Horak, Trends in Biotechnology, 38:1200-1202. 2020.![]() the development of novel control technologies must be focused on species specificity and low environmental impact. Sequence-specific gene silencing via RNAi holds promise for effective management of pest wildlife. Keywords: fertility control, Gene-silencing, genetic biocontrol, interfering RNA, RNAi, toxicant, vertebrates |

Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
RSS