Keywords: viral gene drive

CRISPR engineered viruses could render other viruses harmless

Michael Le Page,  New Scientist,  2023.
A virus genetically engineered to spread its DNA to other viruses via CRISPR gene editing has done exactly that in tests in mice. The hope is that these viruses could alter others, such as herpes, in a way that prevents them from causing symptoms. “It’s a new technology,” ...
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Targeting evolutionary conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirus

M. Walter, R. Perrone and E. Verdin,  bioRxiv,  2021.01.08.425902. 2021.
Here, we analyze in cell culture experiments the evolution of resistance in a gene drive against human cytomegalovirus. We report that after an initial invasion of the wildtype population, a drive-resistant population is positively selected over time and outcompetes gene drive ...
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