Keywords: wMel

Studies on the fitness characteristics of wMel- and wAlbB-introgressed Aedes aegypti (Pud) lines in comparison with wMel- and wAlbB-transinfected Aedes aegypti (Aus) and wild-type Aedes aegypti (Pud) lines

C. Sadanandane, K. Gunasekaran, D. Panneer, S. K. Subbarao, M. Rahi, B. Vijayakumar, V. Athithan, A. Sakthivel, S. Dinesh and P. Jambulingam,  Frontiers in Microbiology,  13:947857. 2022.
Wolbachia, an intracellular maternally transmitted endosymbiont, has been shown to interfere with the replication of dengue virus in Aedes aegypti mosquitoes. The Wolbachia-transinfected Ae. aegypti has been currently released in many countries to test its effectiveness in ...
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Local adaptation of Aedes aegypti mosquitoes to Wolbachia-induced fitness costs

P. A. Ross and A. A. Hoffmann,  bioRxiv,  2022.05.06.490959. 2022.
Aedes aegypti mosquito eggs can remain quiescent for many months before hatching, allowing populations to persist through unfavorable conditions. Aedes aegypti infected with the Wolbachia strain wMel have been released in tropical and subtropical regions for dengue control. wMel ...
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International shipments of Wolbachia-infected mosquito eggs: towards the scaling-up of World Mosquito Program operations

J. A. Denton, D. A. Joubert, A. A. Goundar and J. R. L. Gilles,  Scientific and Technical Review,  41:91-99. 2022.
The Wolbachia insect control method, employed by the World Mosquito Program (WMP), relies on introgressing Wolbachia through target Aedes aegypti populations to reduce the incidence of dengue. Since 2010, the WMP has been producing Wolbachia-infected mosquitoes at numerous sites ...
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Aedes aegypti abundance and insecticide resistance profiles in the applying Wolbachia to eliminate dengue trial

W. Tantowijoyo, S. K. Tanamas, I. Nurhayati, S. Setyawan, N. Budiwati, I. Fitriana, I. Ernesia, D. S. Wardana, E. Supriyati, E. Arguni, Y. Meitika, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, E. Rancès, P. A. Ryan, S. L. O'Neill, K. L. Anders, M. R. A,  PLOS Neglected Tropical Diseases,  16:e0010284. 2022.
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative ...
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Environmental factors influence the local establishment of Wolbachia in Aedes aegypti mosquitoes in two small communities in central Vietnam [version 2]

N. T. Hien, D. D. Anh, N. H. Le, N. T. Yen, T. V. Phong, V. S. Nam, T. N. Duong, N. B. Nguyen, D. T. T. Huong, L. Q. Hung, C. N. T. Trinh, N. V. Hoang, V. Q. Mai, L. T. Nghia, N. T. Dong, L. H. Tho, S. Kutcher, T. P. Hurst, J. L. Montgomery, M. Woolfit, E,  Gates Open Research,  5:147. 2022.
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown to reduce transmission of dengue and other pathogens, under both laboratory and field conditions. Here we describe the entomological outcomes of wMel ...
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Diverse wMel variants of Wolbachia pipientis differentially rescue fertility and cytological defects of the bag of marbles partial loss of function mutation in Drosophila melanogaster

J. E. Bubnell, P. Fernandez-Begne, C. K. S. Ulbing and C. F. Aquadro,  G3 Genes|Genomes|Genetics,  2021.
In Drosophila melanogaster, the maternally inherited endosymbiont Wolbachia pipientis interacts with germline stem cell genes during oogenesis. One such gene, bag of marbles (bam) is the key switch for differentiation and also shows signals of adaptive evolution for protein ...
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Assessment of fitness and vector competence of a New Caledonia wMel Aedes aegypti strain before field-release

N. Pocquet, O. O’Connor, H. A. Flores, J. Tutagata, M. Pol, D. J. Hooker, C. Inizan, S. Russet, J. M. Duyvestyn, E. C. Pacidônio, D. Girault, D. da Silva Gonçalves, M. Minier, F. Touzain, E. Chalus, K. Lucien, F. Cheilan, T. Derycke, S. Laumond, C. P. Sim,  PLOS Neglected Tropical Diseases,  15:e0009752. 2021.
Dengue represents a risk for almost half of the world’s population, especially throughout the tropics. In New Caledonia, dengue outbreaks have become more frequent in the past decade along with the recent circulation of chikungunya and Zika viruses. The opportunity to use the ...
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