Keywords: X poisoning

The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive

Lawler C., D. , Hernandes, N., Nunez, A. K. P., Bhide, S., Baxter, S. and Robin, C.,  bioRxiv,  2023.06.23.546292. 2023.
A synthetic gene drive that targets haplolethal genes on the X-chromosome can skew the sex ratio towards males. Like an X-shredder strategy it does not involve homing and that has advantages including the reduction in gene drive resistance allele formation. We examine this ...
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