Keywords: ZIKA
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Wolbachia interferes with Zika virus replication by hijacking cholesterol metabolism in mosquito cellsB. Edwards, E. A.-O. X. Ghedin and D. A.-O. Voronin, Microbiology Spectrum, 2023.
Zika virus is a member of the arbovirus Flaviviridae family transmitted by Aedes mosquitos and it is associated with microcephaly in infants born to infected mothers. Wolbachia is an intracellular gram-negative alpha-proteobacteria that infects many species of arthropods, ... |
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Wolbachia -mediated resistance to Zika virus infection in Aedes aegypti is dominated by diverse transcriptional regulation and weak evolutionary pressuresE. C. Boehm, A. S. Jaeger, H. J. Ries, D. Castañeda, A. M. Weiler, C. C. Valencia, J. Weger-Lucarelli, G. D. Ebel, S. L. O'Connor, T. C. Friedrich, M. Zamanian and M. T. Aliota, bioRxiv, 2023.
A promising candidate for arbovirus control and prevention relies on replacing arbovirus-susceptible Aedes aegypti populations with mosquitoes that have been colonized by the intracellular bacterium Wolbachia and thus have a reduced capacity to transmit arboviruses. This reduced ... |
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Engineered Antiviral Sensor Targets Infected MosquitoesE. Dalla Benetta, A. J. Lopez-Denman, H.-H. Li, R. A. Masri, D. J. Brogan, M. Bui, T. Yang, M. Li, M. Dunn, M. J. Klein, S. Jackson, K. Catalan, K. R. Blasdell, P. Tng, I. Antoshechkin, L. S. Alphey, P. N. Paradkar and O. Akbari, bioRxiv, 2023.01.27.525922. 2023.
Escalating vector disease burdens pose significant global health risks, so innovative tools for targeting mosquitoes are critical. We engineered an antiviral strategy termed REAPER (vRNA Expression Activates Poisonous Effector Ribonuclease) that leverages the programmable ... |
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Outbreaks of arboviruses, biotechnological innovations and vector control: facing the unexpectedC. Boëte, Innovative Strategies for Vector Control, 6:219-231. 2022.
Outbreaks of arboviruses have occurred in the last decades in many places around the world and a variety of responses have been taken in order to control them. Responses ranged from vaccination campaigns to the use of conventional vector control methods. Innovative approaches ... |
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Wolbachia wPip Blocks Zika Virus Transovarial Transmission in Aedes albopictusY. Guo, J. Guo, Y. Li, X. Zheng and Y. Wu, Microbiol Spectrum, e0263321. 2022.
Area-wide application of Wolbachia to suppress mosquito populations and their transmitted viruses has achieved success in multiple countries. However, the mass release of Wolbachia-infected male mosquitoes involves a potential risk of accidentally releasing fertile females. In ... |
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Modeling the impact of genetically modified male mosquitoes in the spatial population dynamics of Aedes aegyptiM. R. da Silva, P. H. G. Lugão, F. Prezoto and G. Chapiro, Scientific Reports, 12:9112. 2022.
The mosquito Aedes aegypti is the primary vector of diseases such as dengue, Zika, chikungunya, and yellow fever. Improving control techniques requires a better understanding of the mosquito’s life cycle, including spatial population dynamics in endemic regions. One of the most ... |
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Mosquitoes Genetically Modified to Stop Disease Pass Early TestL. Rapaport, WebMD, 2022.
Genetically modified mosquitoes released in the U.S. appear to have passed an early test that suggests they might one day help reduce the population of insects that transmit infectious diseases. As part of the test, scientists released nearly 5 million genetically engineered ... |
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A metapopulation approach to identify targets for Wolbachia-based dengue controlA. Reyna-Lara, D. Soriano-Paños, J. H. Arias-Castro, H. J. Martínez and J. Gómez-Gardeñes, Chaos, 32:041105. 2022.
Over the last decade, the release of Wolbachia-infected Aedes aegypti into the natural habitat of this mosquito species has become the most sustainable and long-lasting technique to prevent and control vector-borne diseases, such as dengue, zika, or chikungunya. However, the ... |
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Genetically Modified Mosquitoes May Be Released in California, Experts Express ConcernZ. Papadakis, NEWSMAX, 2022.
Millions of genetically engineered mosquitos could soon be set loose in California in an effort to curb the disease-carrying Aedes aegypti mosquito population — but some experts are concerned that it could backfire. On March 7, Oxitec, a private company, obtained a permit from ... |
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Genetic Stability and Fitness of Aedes aegypti Red-Eye Genetic Sexing Strains With Pakistani Genomic Background for Sterile Insect Technique ApplicationsM. Misbah-ul-Haq, D. O. Carvalho, L. D. de la Fuente, A. A. Augustinos and K. Bourtzis, Frontiers in Bioengineering and Biotechnology, 10. 2022.
The mosquito species Aedes aegypti is the primary transmitter of viruses that cause endemic diseases like dengue in Pakistan. It is also a cause of other vector-borne diseases like yellow fever, Zika fever, and chikungunya, which significantly impact human health worldwide. In ... |
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CRISPR Technology Can Eliminate Disease-Spreading MosquitoesS. Krishana, Now, 2022.
Scientists have uncovered a new technique they call the “precision-guided sterile insect technique,” or pgSIT. While most CRISPR procedures affect organisms that spread diseases by passing a gene change down generations, this system is more limited. It targets male mosquito ... |
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Genomic insertion locus and Cas9 expression in the germline affect CRISPR/Cas9-based gene drive performance in the yellow fever mosquito Aedes aegyptiW. R. Reid, J. Lin, A. E. Williams, R. Juncu, K. E. Olson and A. W. E. Franz, bioRxiv, 2021.12.08.471839. 2021.
The yellow fever mosquito Aedes aegypti is a major vector of arthropod-borne viruses, including dengue, chikungunya, and Zika. A novel approach to mitigate arboviral infections is to generate mosquitoes refractory to infection by overexpressing antiviral effector molecules. Such ... |
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wMel Wolbachia genome remains stable after 7 years in Australian Aedes aegypti field populationsK. R. Dainty, J. Hawkey, L. M. Judd, E. C. Pacidônio, J. M. Duyvestyn, D. S. Gonçalves, S. Y. Lin, T. B. O'Donnell, S. L. O'Neill, C. P. Simmons, K. E. Holt and H. A. Flores, Microbial Genomics, 7. 2021.
Infection of wMel Wolbachia in Aedes aegypti imparts two signature features that enable its application for biocontrol of dengue. First, the susceptibility of mosquitoes to viruses such as dengue and Zika is reduced. Second, a reproductive manipulation is caused that enables wMel ... |
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The (Losing) Battle Against Mosquitoes In TexasJ. Clayton, Texas Public Radio, 2021.
Jerry Clayton: Mosquitoes are a fact of life in Texas, and the battle against the pesky biting insects is never ending. But there are some new weapons on the horizon. Zach Adleman is an associate professor of entomology at Texas A&M University. He joins us today. Thanks for being ... |
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How to engage communities on a large scale? Lessons from World Mosquito Program in Rio de Janeiro, Brazil [version 2; peer review: 1 approved, 2 approved with reservations]G. B. Costa, R. Smithyman, S. L. O'Neill and L. A. Moreira, Gates Open Research, 2021.
Here we discuss and analyse the framework for community engagement implemented by the WMP in Brazil, during the large-scale deployment of the method in the municipalities of Niterói and Rio de Janeiro, Brazil. Our experience indicates that the community engagement work for ... |
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Mosquitoes genetically modified to be resistant to ZikaStaff, Lab+Life Scientist, 2021.
Researchers have wrestled with different strategies for controlling the spread of Zika virus, which is transmitted to humans from female mosquito bites. One approach, which has been approved by the US Environmental Protection Agency, will see more than 750 million genetically ... |
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Genetically-modified mosquitoes key to stopping Zika virus spreadUniversity of Missouri, Medical Xpress, 2021.
Alexander Franz, an associate professor in the MU College of Veterinary Medicine, collaborated with researchers at Colorado State University by using CRISPR gene-editing technology to produce mosquitoes that are unable to replicate Zika virus and therefore cannot infect a human ... |
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CRISPR/Cas9 knockout of female-biased genes AeAct-4 or myo-fem in Ae. aegypti results in a flightless phenotype in female, but not male mosquitoesS. O’Leary and Z. N. Adelman, PLOS Neglected Tropical Diseases, 14:e0008971. 2020.
Author summary Ae. aegypti is the most important vector of arboviruses throughout the world, and new strategies are urgently needed to add to our existing arsenal of control methods to prevent or halt disease transmission. Importantly, only female Ae. aegypti mosquitoes transmit ... |
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Reply to: “Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported”C. Souto-Maior, J. G. King, L. M. Sartori, R. Maciel-de-Freitas and M. G. M. Gomes, Nature Communications, 11:6113. 2020.
Ant et al.4 claim that concerns with the data and broader analysis make our conclusions misleading. We herein respond to their comments by demonstrating the robustness of our results to different treatments of the data, and expand our arguments for replacing currently adopted ... |
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Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supportedT. H. Ant, M.-V. Mancini, J. Martinez and S. P. Sinkins, Nature Communications, 11:6111. 2020.
King et al.3 used DENV infection and transmission modelling to reinterpret experimental data from two previous studies4,5. The authors claimed that wMel Wolbachia increase the mean susceptibility of Ae. aegypti to DENV, contradicting various other studies6,7,8,9,10,11,12. Here, ... |
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Incorporating Characteristics of Gene Drive Engineered Ae. aegypti as Methods to Reduce Dengue and Zika Virus into the Bayesian Network – Relative Risk Model, Using Ponce, Puerto Rico as a Case StudyS. R. Eikenbary, WWU Graduate School Collection, 2020.
The Bayesian network relative risk model can perform the risk assessment of gene drive engineered Ae. aegypti for vector control and as part of an adaptive management strategy to reduce dengue and Zika transmission. This study illustrates how the BN-RRM can integrate gene drive ... |
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Genetically Modified Mosquitoes Approved For Insect Population Control In The U.S.J. Blum, HUFFPOST, 2020.Genetically modified mosquitoes with the ability to prevent other mosquitoes from spreading deadly diseases may be making their way to Florida backyards in the near future. British biotech group Oxitec announced on Tuesday that the company had won both federal and state ... |
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Florida says ‘this is fine’ to release of genetically modified mosquitoesJ. K. Elliot, Global News, 2020.
That’s the question hanging over a recent decision by state regulators in Florida, which would allow the biotech company Oxitec to unleash hundreds of millions of genetically modified male mosquitoes in the Florida Keys. The lab-altered, patented insects are members of Aedes ... |
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Plan to Release GMO Mosquitoes Moves AheadA. Dier, newser, 2020.
A plan to set loose 750 million genetically modified mosquitoes in Florida and Texas will move forward despite concerns from environmentalists who liken it to a "Jurassic Park experiment." The non-biting male Aedes aegypti mosquitoes developed by British biotechnology company ... |
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Genetically engineered mosquitoes get EPA approval for Florida release despite objections from environmental groupsS. LaMotte, CNN Health, 2020.
A genetically modified male mosquito named OX5034 has received both state and federal approval to be released into the Florida Keys now through 2022, against the objection of many local residents and a coalition of environmental advocacy groups. "The administration has used ... |
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Florida Keys plans killer insect attack on disease-carrying mosquitoesP. Brinkmann, UPI, 2020.
The Florida Keys is close to adding a new weapon to help control a mosquito-borne disease -- genetically modified mosquitoes that produce dead offspring. Outbreaks of dengue fever in the Keys in recent years prompted local authorities to consider the genetically modified bugs ... |
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Plan to release genetically modified mosquitoes in Florida gets go-aheadO. Milman, The Guardian, 2020.
A plan to release a horde of 750 million genetically modified mosqutioes in Florida and Texas is a step closer to fruition after a state regulator approved the idea, over the objections of many environmentalists. |
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Fact check: Genetically modified mosquitoes are cleared for release in the USA. Staver, USA Today, 2020.
The Environmental Protection Agency approved an experimental use permit May 1 that allows Oxitec to release genetically modified mosquitoes in the Florida Keys and Harris County, Texas, where Houston is located. |
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Editorial Expression of Concern: Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural PopulationB. R. Evans, P. Kotsakiozi, A. L. Costa-Da-Silva, R. S. Ioshino, L. Garziera, M. C. Pedrosa, A. Malavasi, J. F. Virginio, M. L. Capurro and J. R. Powell, Scientific Reports, 10:2. 2020.
Shortly after publication of this Article in September 2019, the Editors were alerted to concerns regarding the interpretation of the data and some of the conclusions. |
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Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural PopulationB. R. Evans, P. Kotsakiozi, A. L. Costa-da-Silva, R. S. Ioshino, L. Garziera, M. C. Pedrosa, A. Malavasi, J. F. Virginio, M. L. Capurro and J. R. Powell, Scientific Reports, 9:6. 2019.
We genotyped the release strain and the target Jacobina population before releases began for >21,000 single nucleotide polymorphisms (SNPs). Genetic sampling from the target population six, 12, and 27-30 months after releases commenced provides clear evidence that portions of the ... |
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Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAsBuchman, AG, S.; Li, M.; Antoshechkin, I.; Li, H. H.; Wang, H. W.; Chen, C. H.; Klein, M. J.; Duchemin, J. B.; Paradkar, P. N.; Akbari, O. S., Proceedings of the National Academy of Sciences of the United States of America, 116:3656-3661. 2019.
Recent Zika virus (ZIKV) outbreaks have highlighted the necessity for development of novel vector control strategies to combat arboviral transmission, including genetic versions of the sterile insect technique, artificial infection with Wolbachia to reduce population size and/or ... |
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A secret weapon against Zika and other mosquito-borne diseasesNina Federoff, TEDxMidAtlantic, 2017.
Where did Zika come from, and what can we do about it? Molecular biologist Nina Fedoroff takes us around the world to understand Zika's origins and how it spread, proposing a controversial way to stop the virus -- and other deadly diseases -- by preventing infected mosquitoes ... |
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Genetically Modified Mosquitoes Probably Headed to Florida Keys to Fight ZikaT. Elfrink, Miami New Times, 2016.
The bad news: Zika is coming to Florida. This past Friday, two new cases of the virus linked to serious birth defects were reported in the state, and scientists believe it could spread rapidly come summer as mosquito populations explode. And we're still a long way away from a ... |
