How can genetically modified mosquitoes be safely tested in laboratory settings?

The American Committee of Medical Entomology has issued guidance for the safe handling of arthropod vectors of human and animal disease agents, including mosquitoes. These describe the facilities and training required to guard against unauthorized release from containment. They include considerations for vectors that contain recombinant DNA molecules, and those that have been modified with transgenes capable of gene drive. These recommendations take a risk-based approach, with containment requirements varying according to the potential consequences of premature releases.

For more information:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396570/
https://www.liebertpub.com/doi/10.1089/vbz.2021.0035