What would it take for the gene drive system be functional in a second species?

For an engineered gene drive to function, a small number of genes contained within the gene drive element need to be expressed in the right cells and at the right time within the target organism. The genetic switches that turn those important genes on and off at the right time will not function in all species, particularly species distantly related to the original host species. So not only will the gene drive need to get into the right cells (germline cells) of a second organism so that it has the possibility of being transmitted to subsequent generations, but all of the components of the gene drive will need to function properly in the new host.