Gene Drive Basics - Biosafety

Final action under NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules

Federal Register, National Institutes of Health,  2024.
Changes to the NIH Guidelines to include specific considerations and requirements for conducting research involving gene drive modified organisms in contained research settings.

Points to consider in seeking biosafety approval for research, testing, and environmental release of experimental genetically modified biocontrol products during research and development

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W. K. Tonui, V. Ahuja, C. J. Beech, J. B. Connolly, B. Dass, D. C. M. Glandorf, et al.,  Transgenic Research,  31:607. 2022.
Novel genetically modified biological control products (referred to as “GM biocontrol products”) are being considered to address a range of complex problems in public health, conservation, and agriculture, including preventing the transmission of vector-borne parasitic and ...

Infravec2 guidelines for the design and operation of containment level 2 and 3 insectaries in Europe

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E. Pondeville, A.-B. Failloux, F. Simard, P. Volf, A. Crisanti, R. E. Haghighat-Khah, N. Busquets, F. X. Abad, A. J. Wilson, R. Bellini, S. Marsh Arnaud, A. Kohl and E. Veronesi,  Pathogens and Global Health,  2022.
With the current expansion of vector-based research and an increasing number of facilities rearing arthropod vectors and infecting them with pathogens, common measures for containment of arthropods as well as manipulation of pathogens are becoming essential for the design and ...

World Health Organization laboratory biosafety manual, 4th edition

Geneva: World Health Organization,  2022.
International laboratory biosafety guidance describing best practices and a risk assessment framework to promote a responsible safety culture globally.

Containment Practices for Arthropods Modified with Engineered Transgenes Capable of Gene Drive Addendum 1 to the Arthropod Containment Guidelines, Version 3.2

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American Committee of Medical Entomology,  Vector-Borne and Zoonotic Diseases,  2021.
Responsible conduct of research is a cornerstone of rigorous scientific discovery. Institutional committees, independent advisory panels, and expert steering groups are among the frameworks in academia meant to provide guidance and assurances that research activities do not ...

Biosafety in microbiological and biomedical laboratories (BMBL), 6th edition

US Department of Health and Human Services, Public Health Service,  2020.
Publication from the US CDC and NIH recommending best practices for the safe conduct of work in biomedical and clinical laboratories from a biosafety perspective.

Arthropod containment guidelines, version 3.2

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American Committee of Medical Entomology,  American Society of Tropical Medicine and Hygiene Vector-Borne and Zoonotic Diseases,  19:3:152-173. 2019.
In 2003, just a few months after I became editor of Vector-; Borne and Zoonotic Diseases, we published the Arthropod; Containment Guidelines, likely our first of what would become; known as an Open Access publication. The concept to; produce the guidelines resulted from a ...