Gene Drive in the News
A curated collection of articles from the popular press
ISAAA Inc. | Genetic Tools For Conservation and Health: What’s The Role of Gene Drives?
28634Kristine Grace N. Tome, Science Speaks, 2023-12-04 11:20:10.
ISAAA Inc., in partnership with the Outreach Network for Gene Drive Research and the Malaysian Biotechnology Information Centre (MABIC), gathered approximately 834 online participants during the webinar Genetic Tools for Conservation and Health: What's the Role of Gene Drives? held on November 16, 2023, via Zoom and livestreamed on Facebook and YouTube. The online session is the first of the 2023 Gene Drive Webinar Series that focuses on the interests of specific countries and aims to promote a productive and balanced conversation on the benefits and risks of possible gene drive applications relevant to national priorities. The Philippines has been picked as the first country to be engaged in the webinar series. The Philippines has been at the forefront of biotechnology research and regulation in Asia for a long time and plays an important role in shaping the region’s views on novel technologies and developing expertise.
Invasive Feral Cats Could Be Wiped Out Using Genetic Modification
28632Jess Thomson, Newsweek, 2023-12-04 10:38:32.
Hordes of feral cats terrorizing native species in Australia could be combatted using a special type of genetic engineering, scientists have suggested. The cats, which came to Australia via European colonizers, regularly kill native mammals, birds, and reptiles, including woylies, quolls, and even penguins. The feral cats now number over six million, and are responsible for the extinction of at least 28 species across the country, threatening countless more. This has spurred numerous control measures to be announced, including poison, trapping, and cat curfews. "Gene drives literally 'drive' modified genes through a species by ensuring they are inherited from generation to generation, eventually resulting in the whole species having engineered genetic traits," Andrew D. Maynard, a professor of Advanced Technology Transitions at Arizona State University, told Newsweek. "It's a technique that is specific to species that mate and reproduce sexually, and works by ensuring that engineered genetic traits are inherited by every single offspring resulting from mating."
What are gene drives, and how can they help eradicate invasive species in Australia?
28563Dr. Ellen Cottingham, ABC News (Australia Broadcasting Corporation), 2023-11-29 13:52:33.
The impact of feral cats and other invasive species is felt across Australia. Not only do they threaten native species, but they can also spread diseases to humans and livestock. Invasive species are estimated to cost Australia an eye-watering $25 billion annually, while the global cost is a staggering $423 billion. Feral cats are everywhere — the nation is home to up to 6.3 million of them, and they are responsible for killing millions of native mammals, reptiles, and birds each day. Minister for the Environment and Water Tanya Plibersek recently declared "war on feral cats", announcing plans involving cat curfews, desexing regulations, and caps on cat numbers in homes. But what can we do about the millions of feral cats already wreaking havoc across Australia? And what about other pests such as foxes, rabbits, cane toads, carp, pigs, deer, or goats? One technique with the potential to help fight not just cats but all invasive species is called a "gene drive".
Ghana publishes its guidelines on Genome Editing
28538Anonymous, BusinessGhana, 2023-11-28 11:06:04.
Ghana's National Biosafety Authority (NBA) has published its guidelines on Genome Editing and Gene Stacks with regards Genetically Modified Organisms (GMOs) joining Nigeria, Kenya, and Malawi, as the fourth country in Africa with the guidelines. Genome editing is an emerging and affordable biotechnology tool that has great promise to deliver high-yielding crop varieties, able to withstand various stresses such as droughts, floods, insect pests, or diseases and possessed quality traits for use as food, feed, or for processing. "Biotechnology is a fast-developing business with new trends of technologies and when the law was being passed, there was nothing like Genome editing, gene drive, or synthetic biotechnology, but we have them now."
New Techniques of Genetic Modification in Pest Control Spark Debate in Canada
28501Sandeep Kunchikor, Express Healthcare Management, 2023-11-26 09:51:07.
Scientists in Canada are urging serious discussions on the use of genetic modification as a new technique in pest control. In a recent report by the Pest Management Regulatory Agency, a branch of Health Canada that regulates pesticide use, experts argue that genetic modification could become a powerful tool as older insecticides lose their effectiveness and climate change leads to new infestations. Already, such techniques are being tested to prevent mosquitoes from spreading malaria. However, the authors of the report caution that there are many unknown variables. They claim that the consequences of releasing synthetic versions of natural organisms could be harmful and permanent.
Scientific report urges debate on genetic modification to control insect pests
28490Bob Weber, CTV News, 2023-11-18 11:21:22.
Scientists are learning to turn the genetics of insect pests against themselves, altering the genome of familiar foes in ways that give farmers and doctors new ways to fight them. The burgeoning field offers fresh hope against old scourges such as malaria. And it could provide shiny new tools as familiar insecticides lose their punch and climate change shuffles the deck. But concerns buzz the new technology like a cloud of gnats. "Genetic pest-control tools could dramatically shift our relationship with the environment, not only because of their potential impact on the ecosystem of which we are a part, but also because of their challenge to the social and cultural values that shape decisions surrounding their use," says a new report from the Council of Canadian Academies.
Mosquito modification programme aiming to eliminate malaria receives US$15m
28402Hayley Dunning, Imperial College London, 2023-11-14 15:15:02.
Half of the world’s population is at risk of contracting malaria, a disease caused by parasites that are transmitted from one person to another through bites from Anopheles mosquitoes. In 2021 alone, there were over 247 million cases and 619,000 deaths from malaria, mostly children under five years old in sub-Saharan Africa. With current measures failing to halt disease transmission, new ways to control the spread of malaria are desperately needed. Transmission Zero is a global programme led by scientists at Imperial College London (Imperial) and the Ifakara Health Institute (IHI) of Tanzania, in partnership with the Tanzanian National Institute of Medical Research (NIMR), which aims to modify specific species of mosquitoes so that they are unable to transmit the disease.
Inside Gates Foundation’s $15M effort to release gene-hacked mosquitoes that end malaria with ‘killer sex’
28407Jona Jaupi, The U.S. Sun, 2023-11-14 10:26:29.
Malaria is a mosquito-borne disease caused by parasites and poses a significant threat to nearly half of the world's population. In 2021, an estimated 247 million people contracted malaria, with a staggering 619,000 deaths, per Imperial College. Most of those deaths affected children under five in sub-Saharan Africa. Because current methods for fighting malaria are falling short, innovative approaches are required – enter Transmission Zero. The program's end goal is to genetically modify specific mosquito species to make them incapable of transmitting the disease. The way this works is that the gene-modified mosquitoes get sent out into the world to breed with wild mosquitoes. The result is a new generation of mosquitoes that are born with an antimalarial modification.
What are gene drives?
28374Anonymous, MalariaGEN, 2023-11-09 09:43:47.
Among the new generation of technological tools being developed to combat malaria, there is a lot of buzz around gene drives. This is a method for genetically modifying malaria-spreading mosquitoes and ultimately reducing or replacing their populations. But how exactly do gene drives work? And how can genomic surveillance data produced by the MalariaGEN community help gene drive researchers achieve their goals safely and effectively?
Oxitec concludes GMO mosquito release phase
28361Anonymous, keysnews.com, 2023-11-08 09:35:19.
Oxitec and the Florida Keys Mosquito Control District announced last week that the release phase during the third season of the FKMCD-Oxitec Mosquito Project has concluded for the 2023 season. Mosquito population monitoring will continue for the next several weeks.9
Male-killing virus leads to more female moths
28365Anonymous, Nature, 2023-11-07 09:51:08.
Keisuke Nagamine at Minami Kyushu University in Miyazaki, Japan, and his colleagues have identified another virus that kills male embryos of the tobacco caterpillar, Spodoptera litura. Female moths infected with the virus produced an equal number of male and female embryos, but almost no male embryos survived. The virus doesn’t share male-killing genes with other known male-killing viruses or bacteria, suggesting that these mechanisms evolved independently.
Success of Wolbachia-infected mosquitoes in fighting dengue may be underestimated
28353B. Wampler, Notre Dame News, 2023-11-06 11:04:57.
Now, researchers at the University of Notre Dame have conducted an analysis of the World Mosquito Program’s randomized control trial of Wolbachia-infected mosquitoes in Indonesia, looking at how excluding transmission dynamics impacted the original interpretation of the trial’s results. “Randomized controlled trials are the gold standard for evaluating the efficacy of any medical or public health intervention. That is very difficult for vector interventions against dengue because incidence of the disease can be somewhat unpredictable and sporadic, requiring very large-scale trials,” said Alex Perkins, associate professor of biological sciences at Notre Dame and senior author on the study. The study published in BMJ Global Health used mathematical models to analyze dengue virus transmission during the Indonesia trial. They explored three biases, or sources of potential error, that the trial is subject to: human movement, mosquito movement and the combined transmission dynamics between human and mosquito movement.
Research breakthrough in genetic biocontrol striving to transform pest management: Centre for Invasive Species Solutions
28332ARR News, Australian Rural and Regional News, 2023-11-02 13:31:54.
A potential new non-lethal and ethical approach to control invasive mammal pests was showcased at a briefing held at the South Australian Health and Medical Research Institute in Adelaide on Tuesday 31 October. Hosted by the Centre for Invasive Species Solutions and the University of Adelaide, the briefing introduced guests to a world-first breakthrough in gene drive technology. The University of Adelaide discovery is the first time a new genetic tool has been identified that is able to induce female infertility into a mouse population, offering a non-lethal way to control mice and rats. Importantly, these findings could be transferred to control other pests, such as rabbits and feral cats.
Bill Gates Talks Gene Drives, mRNA, and U.S.$40m in Science Funding
28314N. Mlambo, allAfrica, 2023-10-31 08:32:46.
In 2003, the Bill and Melinda Gates Foundation launched the Grand Challenges initiative in order to find scientific solutions to these health challenges. Initially, the initiative focused on 14 scientific challenges including focusing on creating effective single-dose vaccines that can be used soon after birth, discovering drugs and delivery systems that minimise the likelihood of drug-resistant micro-organisms, creating therapies that can cure latent infection, and developing needle-free delivery systems. "We started Grand Challenges with two goals. In a narrow sense, we wanted to spur specific advances we thought could lead to breakthroughs. In 2003, we listed ... priorities like creating therapies that could cure latent TB infection - and supported researchers who had exciting ideas in those areas. In a broader sense, we hoped to inspire more brilliant scientists to share big ideas about transforming health in low-income countries. We hoped to create a scientific community that was supported to sustain R&D (Research and Development) for the benefit of billions of people who had been neglected," said co-chair of the Bill & Melinda Gates Foundation Bill Gates during his opening remarks at the Grand Challenges meeting held in Dakar, Senegal.
Genetic tools for conservation and health: What’s the Role of Gene Drive?
28313ISAAA, Institute of Agricultural Science for Southern Viet Nam, 2023-10-31 08:26:25.
The potential uses and impacts of gene drive technologies have garnered increasing interest at the international and national levels across the world. As part of the effort to contribute to an informed debate around gene drive technologies, the Outreach Network for Gene Drive Research and the ISAAA are organizing a new Gene Drive Webinar Series. The first webinar titled Genetic Tools For Conservation and Health: What's The Role of Gene Drives? is scheduled on November 16, 2023, 2 PM GMT+8. The registration is now open to all interested participants. The series is focused on specific countries and aims to promote a productive and balanced conversation on the benefits and risks of possible gene drive applications relevant to national priorities. Kicking off this series is the Philippines, a country that has consistently led biotechnology research and regulation in Asia, and is instrumental in shaping the region's perspectives on innovative technologies and scientific expertise. This first webinar will acquaint attendees with the fundamentals of gene drive and its significance for global health and conservation, presenting some of its prevailing applications under consideration.
Dengue rates drop after release of modified mosquitoes in Colombia
28270M. Lenharo, Nature, 2023-10-27 07:52:00.
Three cities in Colombia saw a dramatic fall in the incidence of dengue in the years following the introduction of mosquitoes carrying Wolbachia, a bacterium that prevents the insect from transmitting viruses. In neighbourhoods where the Wolbachia mosquitoes were well established, dengue incidence dropped by 94–97%. The Aedes aegypti mosquitoes were released by the World Mosquito Program (WMP), a non-profit organization that has been conducting similar experiments in Australia, Brazil, Indonesia and Vietnam, among other countries. In Colombia, the modified mosquitoes were released in one of the country’s most populous regions. “That’s the largest continuous releases of Wolbachia [mosquitoes] globally so far, in terms of the population covered and the area,” says Katie Anders, an epidemiologist at the WMP and Monash University in Melbourne, Australia. Anders presented the results on 22 October at the annual meeting of the American Society of Tropical Medicine and Hygiene in Chicago, Illinois.
How mosquito-controlling bacteria might also enhance insect fertility
28212Public Library of Science, Phys Org, 2023-10-24 13:51:56.
A new study reveals biological mechanisms by which a specific strain of bacteria in the Wolbachia genus might enhance the fertility of the insects it infects—with potentially important implications for mosquito-control strategies. Shelbi Russell of the University of California Santa Cruz, US, and colleagues reported these findings in the open access journal PLOS Biology on October 24th. Different strains of Wolbachia bacteria naturally infect a number of different animals worldwide, such as mosquitos, butterflies, and fruit flies. Wolbachia can manipulate the fertility of their hosts through a specific biological mechanism that aids the spread of Wolbachia within host populations. In recent years, people have harnessed that mechanism in strategies to deliberately infect mosquitos with a specific Wolbachia strain, reducing targeted mosquito populations and thereby potentially reducing the spread of human viruses carried by mosquitos, such as dengue or Zika.
How Genetically Modified Mosquitos can end malaria in Africa – Dr. Santos
28165S. Akioye, The Star, 2023-10-23 12:15:51.
With over 200 million cases every year and nearly 700,000 deaths, Malaria is currently one of Africa’s most dreaded sicknesses. While there have been efforts at finding different drugs for treatment, scientists are working on an innovative solution using genetically modified mosquitoes to eradicate malaria spreading mosquitoes in Africa. In this interview with Dr. Michael Santos of GeneConvene Global Collaborative, SEUN AKIOYE finds out how it will work.
How to fight insects that transmit diseases to people without harming those who cannot?
28157Nation World News Desk, Nation World, 2023-10-20 11:55:16.
One way to avoid this severe environmental impact is to specifically control the population of species that cause problems. This can be done chemically by releasing hormones into the environment that prevent passage to the adult stage, or pheromones that make them believe that a beautiful insect is waiting for them ready for sex, when in fact they fell in the trap of death. The problem with these methods is that sometimes the required molecules are very expensive and not always specific to what we want. A more effective strategy is to sterilize the population of male insects with radioactivity. In nature, these males mate with females, but cannot produce children. This technique has been used for a long time with reasonable results, although it is not 100% effective and the use of radioactivity means the appearance of mutations and it may happen (unlikely) that some give some development for the insect, and a recurring problem for us.However, genetic engineering offers us help. CRISPR/Cas9 is a technology that allows us to make specific changes in a specific area of the genome of any living organism. We can give it a twist and, instead of applying this technique to the genome of an insect by making a specific modification, what we do is modify an insect so that its genome has everything it needs to activate CRISPR/Cas9. time and cause sterility. It’s like hiding in your genome a complete CRISPR/Cas9 kit and the instructions to change a specific gene to create sterility. What is the advantage? If we only disperse the sterile males, those that are not sterile (sterilization is never 100% and we have to compete with the native population) will continue to reproduce, and in a few generations the effect will disappear.
This Burkinabe researcher wants his groundbreaking work to wipe out malaria, altogether
28154B. Orucho and M. Ndengar, The African Mirror, 2023-10-10 11:49:04.
ABDOULAYE Diabaté and his team are betting on gene technology to protect children like his own from malaria. Along with a clutch of brand-new vaccines, the technology could help the world end malaria for good.
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