Perspectives

Opinions on and about gene drive technologies and their uses.

Let’s say we can force the mosquito into extinction — should we do it?

Porterfield, A,  Genetic Literacy Project,  2018.
Not many people like mosquitoes. So why not eliminate them?; Newer techniques like CRISPR/Cas9 gene editing may make this possible. A new study by researchers at Imperial College London showed how CRISPR/Cas9 can generate a mutant gene that renders female mosquitos infertile, ...
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Proposed U.N. test ban on gene drives is idiotic

Bailey, R,  Reason,  2018.
A draft resolution would revise the U.N. Convention on Biological Diversity to call on governments to "refrain from" releasing organisms containing engineered gene drives, according to the MIT Technology Review. A gene drive is a technology that can rapidly propagate a particular ...
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Call for a global moratorium on gene drive releases

Network, TW,  Biosafety Information Centre,  2018.
Gene drives are a genetic engineering tool that aim to force artificial genetic changes through entire populations of animals, insects and plants. Starting on the 17th of November, Parties to the United Nations Convention on Biological Diversity will meet to discuss measures to ...
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United Nations considers a test ban on evolution-warping gene drives

Regalado, A,  MIT Technology Review,  2018.
Debate over a new idea for stopping malaria is pitting some environmental groups against Bill Gates.
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Do not betray Africa on synbio and gene drives

etc group,  etc group,  2018.
As representatives of a broad range of African civil society organisations (CSOs), we do not feel represented by the delegations of Nigeria and South Africa, speaking on behalf of African Group, in their attempt to speak on behalf of the people of Africa on the issue of synthetic ...
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Release of risky GM mosquitoes in Burkina faso highly unethical.

GM Watch,  GM Watch,  2018.
Risky genetically modified (GM) “male-sterile” mosquitoes are due to be released in the near future in Burkina Faso by the Target Malaria research consortium. However, Target Malaria acknowledges that there are no benefits to the proposed GM mosquito release.; ; According to ...
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African Union’s endorsement of unproven gene drive mosquitoes “misguided”

GM Watch,  GMWatch,  2018.
The African Union (AU) is paving the way for the entry of the latest and most controversial form of genetic engineering – gene drive technologies. In July 2018 the AU released a report endorsing the development of the technology as well as "enabling legislation" for their ...
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A Call to Protect Food Systems from Genetic Extinction Technology

Global Food and Agriculture Movement,  etc Group,  2018.
Gene drives threaten natural systems. If released experimentally into the environment they may spread engineered genes uncontrollably through wild and domesticated species. This could alter ecological systems and food webs, harm biodiversity and eradicate beneficial organisms ...
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Just Say No to Agricultural Gene Drives

Bassey-Orovwuje, M.,  Project Syndicate,  2018.
By forcing laboratory-made genes on an entire population or species, cutting-edge gene-drive technologies have the power to transform entire ecosystems in one fell swoop. But where leading industrial agriculture firms see dollar signs, farmers in the regions where gene drives ...
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Gene drive organisms: Warning of risks due to uncontrolled releases

Bender, S.T., C.,  Testbiotech,  2018.

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Gene drive organisms: Warning of risks due to uncontrolled releases

Then, C,  Testbiotech,  2018.
The German Ministry for the Environment has in response to an open letter sent by several civil society organisations issued a statement very critical of genetically engineered organisms carrying a so-called gene drive. The ministry announced that it will take action on an ...
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Forcing the Farm

etc group,  etc group,  2018.
This report is being issued as an alert to governments, civil society organisations and grassroots movements. It points to how gene drives, while promoted as a tool for medicine and conservation, will find their real use in food and farming by agribusiness. It calls for a pause ...
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Letter: Gene Drive and Trust in Science

Boëte, C.,  Gene Watch,  2018.
Committee of Responsible Genetics
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Considerations for the governance of gene drive organisms

Rudenko, L.P., Megan J.; Oye, Kenneth,  Pathogens and Global Health,  2018.
Governance is a broader and more flexible concept than statute-driven regulations as it incorporates components outside the latter?s remit. Considerations of governance are critical in the development of emerging biotechnologies such as gene drive organisms. These have been ...
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Editing nature: Local roots of global governance

Kofler, N.C., James P.; Kuzma, Jennifer; Marris, Emma; Esvelt, Kevin; Nelson, Michael Paul; Newhouse, Andrew; Rothschild, Lynn J.; Vigliotti, Vivian S.; Semenov, Misha; Jacobsen, Rowan; Dahlman, James E.; Prince, Shannon; Caccone, Adalgisa; Brown, Timothy,  Science,  2018.

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Transgenic Mosquitoes – Fact or Fiction?

Wilke, A. B. B., J. C. Beier and G. Benelli,  Trends in Parasitology,  34:456-465. 2018.
echnologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget ...
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Conservation demands safe gene drive

K. M. Esvelt and N. J. Gemmell,  PLOS Biology,  15:e2003850. 2017.
Here, we explore the risk of accidental spread posed by self-propagating gene drive technologies, highlight new gene drive designs that might achieve better outcomes, and explain why we need open and international discussions concerning a technology that could have global ...
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Using CRISPR-based gene drive for agriculture pest control

V. Courtier-Orgogozo, B. Morizot and C. Boëte,  EMBO Reports,  18:1481. 2017.
The authors respond to comments to their publication 10.15252/embr.201744205
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Agricultural pest control with CRISPR-based gene drive: time for public debate

V. Courtier-Orgogozo, B. Morizot and C. Boëte,  EMBO Reports,  18:878-880. 2017.
Gene drive technology to control disease vectors or pests has great potential for addressing humanitarian and public health problems. Its application for pest control in agriculture, however, raises important environmental, social and ethical issues.
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National Academies hit the brakes on gene drive-modified organisms

Abbasi, J.,  JAMA-Journal of the American Medical Association,  316:482-483. 2016.
Despite their potential for fighting Zika, malaria, and other public health scourges, organisms that have been engineered to quickly spread genetic modifications through a population—and possibly an entire species—are not ready for release into the wild, a committee of ...
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