Scholarly Literature
This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives). The latest are shown here.
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Gene drives for vertebrate pest control: realistic spatial modelling of eradication probabilities and times for island mouse populations
Tags: Biodiversity/Conservation, CRISPR, Gene drive synthetic, Modeling, Other mammals, Replicator/site directed nucleaseA. Birand, P. Cassey, J. V. Ross, J. C. Russell, P. Thomas and T. A. A. Prowse, Molecular Ecology, 2022.
Abstract Invasive alien species continue to threaten global biodiversity. CRISPR-based gene drives, which can theoretically spread through populations despite imparting a fitness cost, could be used to suppress or eradicate pest populations. We develop an individual-based, ...
A natural fungal gene drive enacts killing through targeting DNA
Tags: Yeast and FungiA. S. Urquhart and D. M. Gardiner, bioRxiv, 2022.01.19.477016. 2022.
Fungal spore-killers are a class of selfish genetic elements that positively bias their own inheritance by killing non-inheriting gametes following meiosis. As killing takes place specifically within the developing fungal ascus, a tissue which is experimentally difficult to ...
Recently introduced Wolbachia reduces bacterial species richness and reshapes bacterial community structure in Nilaparvata lugens
Tags: Incompatible insect technique, Other Symbionts, WolbachiaT.-P. Li, C.-Y. Zhou, J.-T. Gong, Z. Xi and X.-Y. Hong, Pest Management Science, 2022.
BACKGROUND Wolbachia has been developed as an effective tool to suppress insect pests and arbovirus transmission. Recently, the brown planthopper Nilaparvata lugens, a serious agricultural pest, has been successfully transinfected with Wolbachia strain wStri from Laodelphax ...
Ethical Considerations for Gene Drive: Challenges of Balancing Inclusion, Power and Perspectives
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementA. Kormos, G. C. Lanzaro, E. Bier, V. Santos, L. Nazare, J. Pinto, A. A. dos Santos and A. James, Frontiers in Bioengineering and Biotechnology, 2022.
Progress in gene-drive research has stimulated discussion and debate on ethical issues including community engagement and consent, policy and governance, and decision-making involved in development and deployment. Many organizations, academic institutions, foundations, and ...
IMPACTOS AMBIENTAIS DA TÉCNICA DE GENE DRIVE PARA O CONTROLE DE EPIDEMIAS: ALCANCES E LIMITES DO PRINCÍPIO DA PRECAUÇÃO
Tags: Gene drive, Policy, Risk and safety, Risk assessment, South/Central AmericaN. R. Furtado, PERI Revista de Filosofia, 13. 2022.
The paper discusses the application of the precautionary principle in the management of environmental risks arising from the use of gene drives to control epidemics. Gene drives consist of a technique for creating genetically modified organisms, which are released into an ...
Analysis of a Cas12a-based gene-drive system in budding yeast
Tags: CRISPR, Gene drive synthetic, Yeast and FungiI. C. Lewis, Y. Yan and G. C. Finnigan, Access Microbiol, 3:000301. 2022.
The discovery and adaptation of CRISPR/Cas systems within molecular biology has provided advances across biological research, agriculture and human health. Genomic manipulation through use of a CRISPR nuclease and programmed guide RNAs has become a common and widely accessible ...
Effects of Sterile Males and Fertility of Infected Mosquitoes on Mosquito-Borne Disease Dynamics
Tags: Aedes, Modeling, Mosquitoes, Sterile insect technique (SIT)X. L. Sun, S. Q. Liu, Y. F. Lv and Y. Z. Pei, Bulletin of Mathematical Biology, 84:33. 2022.
By studying an infection-age structured model, we consider the effects of releasing sterile males and the fertility of infected mosquitoes on the mosquito-borne diseases transmission including the extinction of mosquitoes, the elimination and persistence of diseases. Firstly, ...
Gene drive communication: exploring experts’ lived experience of metaphor use
Tags: Gene drive synthetic, Stakeholder engagementB. Nerlich and A. Stelmach, New Genetics and Society, 2022.
Metaphors have been crucial in making genetics and genomics public, fromthe code and the book of life to genetic scissors and gene surgery. A newfield is emerging called“gene drive”–a range of controversial technologiesthat can potentially be used for the eradication or ...
Insect Allies – Assessment of a Viral Approach to Plant Genome Editing
Tags: Agriculture, CRISPR, Gene drive synthetic, Gene editing, Policy, Regulation, Risk and safetyK. Pfeifer, J. L. Frieß and B. Giese, Integrated Environmental Assessment and Management, 2022.
The DARPA program Insect Allies has already sparked scientific debate concerning technology assessment-related issues, among which the most prevalent is that of dual use potential. As apart from the issues concerning peaceful applications, the technology also provides the ...
Characterization of the first Wolbachia from the genus Scaptodrosophila, a male-killer from the rainforest species S. claytoni
Tags: Sex distorter, WolbachiaK. M. Richardson, M. Schiffer, P. A. Ross, J. A. Thia and A. A. Hoffmann, Insect Science, 2022.
Abstract The Scaptodrosophila genus represents a large group of drosophilids with a worldwide distribution and a predominance of species in Australia, but there is little information on the presence and impacts of Wolbachia endosymbionts in this group. Here we describe the first ...
Reversing insecticide resistance with allelic-drive in Drosophila melanogaster
Tags: CRISPR, Gene drive synthetic, Malaria, Mosquitoes, ResistanceB. Kaduskar, R. B. S. Kushwah, A. Auradkar, A. Guichard, M. Li, J. B. Bennett, A. H. F. Julio, J. M. Marshall, C. Montell and E. Bier, Nature Communications, 13:291. 2022.
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr ...
The prince, the mayor, and the U.S. fish that ate Japan
Tags: Aedes, Fish, Gene drive synthetic, Genetic biocontrol, Invasive species, Modeling, Mosquitoes, Sterile insect technique (SIT)C. Elliot, National Geographic, 2022.
When Crown Prince Akihito visited Chicago on October 3, 1960, his sole request was to visit Shedd Aquarium. Then Mayor Richard J. Daley, an avid angler, presented the prince with a gift that he scooped with a net from one of the tanks himself: 18 bluegills, the official Illinois ...
Introgression of the Aedes aegypti red-eye genetic sexing strains into different genomic backgrounds for sterile insect technique applications
Tags: Aedes, Mosquitoes, Sterile insect technique (SIT)A. A. Augustinos , K. Nikolouli , L. D. De La Fuente , M. Misbah-Ul-Haq, D. O. Carvalho and K. Bourtzis, Frontiers in Bioengineering and Biotechnology, 2022.
Aedes aegypti is an invasive mosquito species and major vector of human arboviruses. A wide variety of control methods have been employed to combat mosquito populations. One of them is the sterile insect technique (SIT) that has recently attracted considerable research efforts ...
iGEM and Gene Drives: A Case Study for Governance
Tags: Gene drive synthetic, Governance, Regulation, Risk and safetyP. Millett, T. Alexanian, M. J. Palmer, S. W. Evans, T. Kuiken and K. Oye, Health Security, 2022.
Gene drives have already challenged governance systems. In this case study, we explore the International Genetically Engineered Machine (iGEM) competition's experiences in gene drive-related research and lessons in developing, revising, and implementing a governance system. ...
Lab-scale characterization and semi-field trials of Wolbachia Strain wAlbB in a Taiwan Wolbachia introgressed Ae. aegypti strain
Tags: Dengue, Incompatible insect technique, Mosquito husbandry, Mosquitoes, Population modification/replacement, Population suppression, WolbachiaW. L. Liu, H. Y. Yu, Y. X. Chen, B. Y. Chen, S. N. Leaw, C. H. Lin, M. P. Su, L. S. Tsai, Y. Chen, S. H. Shiao, Z. Y. Xi, A. C. C. Jang and C. H. Chen, PLOS Neglected Tropical Diseases, 16:24. 2022.
Author summaryPrior to open field release, new genetic approaches that interfere with mosquito abilities and reduce mosquito population density require progressive evaluation both in the laboratory and contained field trials. Trials in contained outdoor systems are thus an ...
The Need for a Tiered Registry for US Gene Drive Governance
Tags: Gene drive synthetic, Malaria, Mosquitoes, Policy, Regulation, Risk and safetyK. L. Warmbrod, A. L. Kobokovich, R. West, G. K. Gronvall and M. Montague, Health Security, 2022.
A great deal of attention has been focused on the potential risks of gene drives, the kinds of biosafety protections they may require, and how they may be reversed; however, less attention has been paid to the systems that would be useful to have in place in the future, when ...
Effect of aneuploidy of a nonessential chromosome on gene expression in maize
Tags: Agriculture, Chromosomal driveX. Shi, H. Yang, C. Chen, J. Hou, T. Ji, J. Cheng and J. A. Birchler, Plant Journal, 2022.
The nonessential supernumerary maize B chromosome (B) has recently been shown to contain active genes and be capable of impacting gene expression of the A chromosomes. However, the effect of the B chromosome on gene expression is still unclear. In addition, it is unknown whether ...
An Introduction to Containment Recommendations for Gene Drive Mosquitoes and the Laboratory Rearing of Genetically Engineered Mosquitoes in Africa
Tags: Containment, Gene drive synthetic, Genetic biocontrol, Genetically modified mosquitoes, Policy, Regulation, Risk and safetyS. Higgs, Vector-Borne and Zoonotic Diseases, 2022.
The prospect of using genetically engineered arthropods to reduce the incidence of vector-borne diseases either indirectly by suppressing vector populations or directly by replacing wild-type vector species with less competent ones has long been discussed; however, only in the ...
Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control
Tags: Africa, Containment, Gene drive synthetic, Genetic biocontrol, Genetically modified mosquitoes, MalariaC. Guissou, M. M. Quinlan, R. Sanou, R. K. Ouédraogo, M. Namountougou and A. Diabaté, Vector-Borne and Zoonotic Diseases, 2022.
The Institut de Recherche en Sciences de la Santé (IRSS) of Burkina Faso, West Africa, was the first African institution to import transgenic mosquitoes for research purposes. A shift from the culture of mosquito research to regulated biotechnology research and considerable ...
Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes
Tags: Aedes, Anopheles, Culex, Genetic biocontrol, Mosquito husbandryV. Bottino-Rojas, I. Ferreira, R. D. Nunes, X. Feng, T. B. Pham, A. Kelsey, R. Carballar-Lejarazú, V. Gantz, P. L. Oliveira and A. A. James, Insect Biochemistry and Molecular Biology, 103720. 2022.
Insect ommochrome biosynthesis pathways metabolize tryptophan to generate eye-color pigments and naturally occurring alleles of pathway genes are useful phenotypic markers in transgenesis studies. Pleiotropic effects of mutations in some genes exert a load on both survival and ...
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