Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Does the U.S. public support using gene drives in agriculture? And what do they want to know?

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Jones, MSD, Jason A.; Elsensohn, Johanna; Mitchell, Paul D.; Brown, Zachary S.,  Science Advances,  5:eaau8462. 2019.
Gene drive development is progressing more rapidly than our understanding of public values toward these technologies. We analyze a statistically representative survey (n = 1018) of U.S. adult attitudes toward agricultural gene drives. When informed about potential risks, ...

On the road to a gene drive in mammals

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Conklin, BR,  Nature,  566:43-45. 2019.
A method for making a version of a gene more likely to be inherited than normal, generating what is called a gene drive, might be used to control insect populations. It has now been reported to work in mammals, too.

Transmission ratio distortion is frequent in Arabidopsis thaliana controlled crosses

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Seymour, DKC, E.; Arioz, B. I.; Koenig, D.; Weigel, D.,  Heredity,  122:294-304. 2019.
The equal probability of transmission of alleles from either parent during sexual reproduction is a central tenet of genetics and evolutionary biology. Yet, there are many cases where this rule is violated. The preferential transmission of alleles or genotypes is termed ...

CRISPR gene drive efficiency and resistance rate is highly heritable with no common genetic loci of large effect

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Champer, JW, Z. X.; Luthra, A.; Reeves, R.; Chung, J.; Liu, C.; Lee, Y. L.; Liu, J. X.; Yang, E.; Messer, P. W.; Clark, A. G.,  Genetics,  212:333-341. 2019.
Gene drives could allow for control of vector-borne diseases by directly suppressing vector populations or spreading genetic payloads designed to reduce pathogen transmission. Clustered regularly interspaced short palindromic repeat (CRISPR) homing gene drives work by cleaving ...

Killing two bugs with one stone: a perspective for targeting multiple pest species by incorporating reproductive interference into sterile insect technique

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Honma, AK, N.; Noriyuki, S.,  Pest Management Science,  75:571-577. 2019.
The sterile insect technique is an environmentally friendly method to control and even eradicate agricultural and veterinary insect pests without using chemical pesticides in excess. However, the continuous production and release of sterile insects is economically costly and ...

MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations

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Sánchez C, HMW, Sean L.; Bennett, Jared B.; Marshall, John M.,  Methods in Ecology and Evolution,  10:1-24. 2019.
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its ...

Arthropod containment guidelines, version 3.2

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American Committee of Medical Entomology,  American Society of Tropical Medicine and Hygiene Vector-Borne and Zoonotic Diseases,  19:3:152-173. 2019.
In 2003, just a few months after I became editor of Vector-; Borne and Zoonotic Diseases, we published the Arthropod; Containment Guidelines, likely our first of what would become; known as an Open Access publication. The concept to; produce the guidelines resulted from a ...

Molecular safeguarding of CRISPR gene drive experiments

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Champer, JC, Joan; Lee, Yoo Lim; Liu, Chen; Yang, Emily; Wen, Zhaoxin; Clark, Andrew G.; Messer, Philipp W.,  eLife,  8:e41439. 2019.
CRISPR-based homing gene drives have sparked both enthusiasm and deep concerns due to their potential for genetically altering entire species. This raises the question about our ability to prevent the unintended spread of such drives from the laboratory into a natural population. ...

Population management using gene drive: molecular design, models ofspread dynamics and assessment of ecological risks

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Rode, NOE, A.; Bourguet, D.; Courtier-Orgogozo, V.; Debarre, F.,  Conservation Genetics,  20:671-690. 2019.
CRISPR gene drive has recently been proposed as a promising technology for population management, including in conservation genetics. The technique would consist in releasing genetically engineered individuals that are designed to rapidly propagate a desired mutation or transgene ...

Gene drives as a response to infection and resistance

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Hayirli, TCM, P.F.,  Infection and Drug Resistance,  12:229-234. 2019.
Vector-borne infectious diseases continue to be a major threat to public health. Although some prevention and treatment modalities exist for these diseases, resistance to such modalities, exacerbated by global climate change, remains a fundamental challenge. Developments in ...

Male competition and the evolution of mating and ire-history traits in experimental populations of Aedes aegypti

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Qureshi, AA, A.; Hollis, B.; Ponlawat, A.; Cator, L. J.,  Proceedings of the Royal Society B-Biological Sciences,  286:20190591. 2019.
Aedes aegypti is an important disease vector and a major target of reproductive control efforts. We manipulated the opportunity for sexual selection in populations of Ae. aegypti by controlling the number of males competing for a single female. Populations exposed to higher ...

Variability in the durability of CRISPR-Cas immunity

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Chabas, HN, A.; Meaden, S.; Westra, E. R.; Tremblay, D. M.; Pradier, L.; Lion, S.; Moineau, S.; Gandon, S.,  Philosophical Transactions of the Royal Society B-Biological Sciences,  374:1-9. 2019.
The durability of host resistance is challenged by the ability of pathogens to escape the defence of their hosts. Understanding the variability in the durability of host resistance is of paramount importance for designing more effective control strategies against infectious ...

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

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Prowse, TAAA, F.; Cassey, P.; Thomas, P.; Ross, J. V.,  eLife,  8:19. 2019.
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could be incorporated within ...

Gene drive gone wild: exploring deliberative possibilities by developing One Health ethics

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Capps, B,  Law, Innovation and Technology,  11:231-256. 2019.
Gene editing may be used to engineer organisms that are better or worse adapted to survival. Coupled with gene drives ? molecular genetic strategies that perpetuate specific phenotypes in a target species ? it would now be possible to edit wild animal populations that impact on ...

Knowledge engagement in gene drive research for malaria control

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Hartley, ST, D.; Ledingham, K.; Coulibaly, M.; Diabate, A.; Dicko, B.; Diop, S.; Kayondo, J.; Namukwaya, A.; Nourou, B.; Toe, L. P.,  PLOS Neglected Tropical Diseases,  13:e0007233. 2019.
Scientists and funding bodies have made repeated calls for public engagement in gene drive. In 2016, the National Academies of Sciences, Engineering, and Medicine (NASEM) published its report, Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning ...

Predicting the spatial dynamics of Wolbachia infections in Aedes aegypti arbovirus vector populations in heterogeneous landscapes

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Hancock, PAR, S. A.; Koenraadt, C. J. M.; Scott, T. W.; Hoffmann, A. A.; Godfray, H. C. J.,  Journal of Applied Ecology,  56:1674-1686. 2019.
A promising strategy for reducing the transmission of dengue and other arboviral human diseases by Aedes aegypti mosquito vector populations involves field introductions of the endosymbiotic bacteria Wolbachia. Wolbachia infections inhibit viral transmission by the mosquito, and ...

Safe CRISPR: Challenges and Possible Solutions

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Pineda, ML, A.; Collins, J. P.; Kiani, S.,  Trends in Biotechnology,  37:389-401. 2019.
Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel ...

The ethical landscape of gene drive research

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Callies, DE,  Bioethics,  33:1091-1097. 2019.
Gene drive technology has immense potential. The ability to bypass the laws of Mendelian inheritance and almost ensure the transmission of specific genetic material to future generations creates boundless possibilities. But alongside these boundless possibilities are major social ...

Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans

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Halder, VP, C. B. M.; Chavez, A.; Shapiro, R. S.,  Nature Protocols,  14:955-975. 2019.
The study of fungal pathogens is of immediate importance, yet progress is hindered by the technical challenges of genetic manipulation. For Candida species, their inability to maintain plasmids, unusual codon usage, and inefficient homologous recombination are among the obstacles ...

Population genetics of Anopheles funestus, the African malaria vector, Kenya

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Ogola, EOO, J. O.; Mwangangi, J. M.; Masiga, D. K.; Tchouassi, D. P.,  Parasites & Vectors,  12:15. 2019.
Anopheles funestus is among the major malaria vectors in Kenya and sub-Saharan Africa and has been recently implicated in persistent malaria transmission. However, its ecology and genetic diversity remain poorly understood in Kenya.MethodsUsing 16 microsatellite loci, we examined ...

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