Cas9 Gene Drive, Sex-Conversion and Evolved Resistance

Cas9 Gene Drive, Sex-Conversion and Evolved Resistance

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Anna Buchman,  IGTRCN,  2018.

In a recent manuscript, KaramiNejadRanjbar et al. demonstrate the development of a proof of principle Cas9-based suppression gene drive in D. melanogaster that can be applied to pest insects, and discuss the implications of resistance allele formation for practical use of such a drive system.