New genetic copycatchers detect efficient and precise CRISPR editing in a living organism
New genetic copycatchers detect efficient and precise CRISPR editing in a living organism
Tags: Fruit fly, Gene drive syntheticUNIVERSITY OF CALIFORNIA - SAN DIEGO, UNIVERSITY OF CALIFORNIA - SAN DIEGO, 2021.
Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques. Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier’s laboratory demonstrates that new DNA repair mechanisms could be designed to address the effects of debilitating diseases and damaged cell conditions. The scientists developed a novel genetic sensor called a “CopyCatcher,” which capitalizes on CRISPR-based gene drive technology, to detect instances in which a genetic element is copied precisely from one chromosome to another throughout cells in the body of a fruit fly.
