Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection

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Dong, YS, Maria L.; Marois, Eric; Dimopoulos, George,  PLOS Pathogens,  14:e1006898. 2018.
The causative agent of malaria, Plasmodium, has to complete a complex infection cycle in the Anopheles gambiae mosquito vector in order to reach the salivary gland from where it can be transmitted to a human host. The parasite’s development in the mosquito relies on numerous ...

Genetically engineered mosquitoes, Zika and other arboviruses, community engagement, costs, and patents: Ethical issues

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Meghani, ZB, Christophe,  PLOS Neglected Tropical Diseases,  12:e0006501. 2018.
We discuss here key ethical questions raised by the use of GE insects, with the aim of fostering discussion between the public, researchers, policy makers, healthcare organizations, and regulatory agencies at the local, national, and international levels. We affect that goal by ...

Carrying a selfish genetic element predicts increased migration propensity in free-living wild house mice

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Runge, J-NL, Anna K.,  Proceedings of the Royal Society B: Biological Sciences,  285:20181333. 2018.
Life is built on cooperation between genes, which makes it vulnerable to parasitism. Selfish genetic elements that exploit this cooperation can achieve large fitness gains by increasing their transmission relative to the rest of the genome. This leads to counter-adaptations that ...

CRISPR-based gene drives for pest control

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McFarlane, GRW, C. Bruce A.; Lillico, Simon G.,  Trends in Biotechnology,  36:130-133. 2018.
Clustered regularly interspaced short palindromic repeats (CRISPR)-based gene drives (GDs) could be used to spread desirable genetic elements through wild populations. With the imminent development of this technology in vertebrates, we believe that it is timely to highlight two ...

Invasion and migration of spatially self-limiting gene drives: A comparative analysis

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Dhole, S.; Vella, M. R; Lloyd, A. L.; Gould, F.,  Evolutionary Applications,  11:794-808. 2018.
Recent advances in research on gene drives have produced genetic constructs that could theoretically spread a desired gene (payload) into all populations of a species, with a single release in one place. This attribute has advantages, but also comes with risks and ethical ...

Can CRISPR-based gene drive be confined in the Wild? A question for molecular and population biology

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Marshall, JMA, Omar S.,  ACS Chemical Biology,  13:424-430. 2018.
The recent discovery of CRISPR and its application as a gene editing tool has enabled a range of gene drive systems to be engineered with greater ease. In order for the benefits of this technology to be realized, in some circumstances drive systems should be developed that are ...

Gene drives in our future: challenges of and opportunities for using a self-sustaining technology in pest and vector management

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Collins, JP,  BMC Proceedings,  12:9. 2018.
Gene drives are systems of biased inheritance that enhance the likelihood a sequence of DNA passes between generations through sexual reproduction and potentially throughout a local population and ultimately all connected populations of a species. Gaps in our knowledge of gene ...

Gene drive gets safety features limiting risk for a tool that could alter entire species

Collins, CH,  Scientific American,  319:37-38. 2018.
Research into a genetic engineering technology that can permanently change the traits of a population or even an entire species is progressing rapidly. The approach uses gene drives—genetic elements that pass from parents to unusually high numbers of their offspring, thereby ...

Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta

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Ross, KGS, DeWayne,  BMC Genetics,  19:101. 2018.
The Sb supergene in the fire ant Solenopsis invicta determines the form of colony social organization, with colonies whose inhabitants bear the element containing multiple reproductive queens and colonies lacking it containing only a single queen. Several features of this ...

Veni, vidi, vici: the success of wtf meiotic drivers in fission yeast

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López Hernández, JFZ, Sarah E.,  Yeast,  35:447-453. 2018.
Meiotic drivers are selfish DNA loci that can bias their own transmission into gametes. Owing to their transmission advantages, meiotic drivers can spread in populations even if the drivers or linked variants decrease organismal fitness. Meiotic drive was first formally described ...

Development of a multi-locus CRISPR gene drive system in budding yeast

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Yan, YF, Gregory C.,  Scientific reports,  8:17277-17277. 2018.
The discovery of CRISPR/Cas gene editing has allowed for major advances in many biomedical disciplines and basic research. One arrangement of this biotechnology, a nuclease-based gene drive, can rapidly deliver a genetic element through a given population and studies in fungi and ...

Population dynamics of underdominance gene drive systems in continuous space

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Champer, JZ, Joanna; Champer, Sam; Liu, Jingxian; Messer, Philipp W.,  bioRxiv,  449355:1-23. 2018.
Underdominance gene drive systems promise a mechanism for rapidly spreading payload alleles through a local population while otherwise remaining confined, unable to spread into neighboring populations due to their frequency-dependent dynamics. Such systems could provide a new ...

Recent advances in threshold-dependent gene drives for mosquitoes

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Leftwich, PTE, Matthew P.; Harvey-Samuel, Tim; Carabajal Paladino, Leonela Z.; Norman, Victoria C.; Alphey, Luke,  Biochemical Society Transactions,  46:1203-1212. 2018.
Mosquito-borne diseases, such as malaria, dengue and chikungunya, cause morbidity and mortality around the world. Recent advances in gene drives have produced control methods that could theoretically modify all populations of a disease vector, from a single release, making whole ...

Tuning CRISPR-Cas9 gene grives in Saccharomyces cerevisiae

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Roggenkamp, EG, Rachael M.; Schrock, Madison N.; Turnquist, Emily; Halloran, Megan; Finnigan, Gregory C.,  G3-Genes Genomes Genetics,  8:999. 2018.
Control of biological populations is an ongoing challenge in many fields, including agriculture, biodiversity, ecological preservation, pest control, and the spread of disease. In some cases, such as insects that harbor human pathogens (e.g., malaria), elimination or reduction of ...

Reducing resistance allele formation in CRISPR gene drive

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Champer, JL, Jingxian; Oh, Suh Yeon; Reeves, Riona; Luthra, Anisha; Oakes, Nathan; Clark, Andrew G.; Messer, Philipp W.,  Proceedings of the National Academy of Sciences of the United States of America,  115:5522-5527. 2018.
A functioning gene drive mechanism could fundamentally change our strategies for the control of vector-borne diseases, such as malaria, dengue, and Zika. CRISPR homing gene drive promises such a mechanism, which could be used to rapidly spread genetic modifications among the ...

RPM-Drive: A robust, safe, and reversible gene drive system that remains functional after 200+ generations

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Reed, FAA-M, Todd G.; Costantini, Maria S.; Láruson, Áki J.; Sutton, Jolene T.,  arXiv,  1806.05304:1-19. 2018.
Despite the advent of several novel, synthetic gene drive mechanisms and their potential to one-day control a number of devastating diseases, among other applications, practical use of these systems remains contentious and risky. In particular, there is little in the way of ...

The use of driving endonuclease genes to suppress mosquito vectors of malaria in temporally variable environments

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Lambert, BN, Ace; Burt, Austin; Godfray, H. Charles J.,  Malaria Journal,  17:154. 2018.
The use of gene drive systems to manipulate populations of malaria vectors is currently being investigated as a method of malaria control. One potential system uses driving endonuclease genes (DEGs) to spread genes that impose a genetic load. Previously, models have shown that ...

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

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Kyrou, KH, Andrew M.; Galizi, Roberto; Kranjc, Nace; Burt, Austin; Beaghton, Andrea K.; Nolan, Tony; Crisanti, Andrea,  Nature Biotechnology,  36:1062–1066. 2018.
In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control differentiation of the two sexes. The female transcript, unlike the male, contains an exon (exon 5) ...

Catch me if you can: A spatial model for a brake-driven gene drive reversal

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Calvez, V,,Debarre, F., Girardin, Leo,  arXiv,  1812.06641:1-30. 2018.
We successfully prove that, whenever the drive fitness is at most 50% of the wild-type one while the brake fitness is close to the wild-type one, co-extinction of the brake and the drive occurs in the long run.

Correction to ‘Dodging silver bullets: good CRISPR gene-drive design is critical for eradicating exotic vertebrates’

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Prowse, TAAC, Phillip; Ross, Joshua V.; Pfitzner, Chandran; Wittmann, Talia; Thomas, Paul,  Proceedings of the Royal Society B: Biological Sciences,  285:1-2. 2018.
Proc. R. Soc. B 284, 20170799. (Published Online 9 August 2017). (doi:10.1098/rspb.2017.0799)We recently found an error in our calculation of the probability of a wild-type allele moving from s to j susceptible sites (), and acquiring the gene drive (), during gene-drive homing, ...

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