Catch me if you can: A spatial model for a brake-driven gene drive reversal

Calvez, V,,Debarre, F., Girardin, Leo,  arXiv,  1812.06641:1-30. 2018.

We consider a reaction–diffusion system modeling the co-invasion of a gene drive (an allele biasing inheritance, increasing its own transmission to offspring) and a brake (an “antidote” to a gene drive) in a population carrying a wild-type allele. We successfully prove that, whenever the drive fitness is at most 50% of the wild-type one while the brake fitness is close to the wild-type one, co-extinction of the brake and the drive occurs in the long run. On the contrary, if the drive fitness is at least 50% of the wild-type one, then co-extinction is impossible. Based on numerical experiments, we argue in favor of a global co-extinction conjecture provided the drive fitness is at most 50% of the wild-type one. The proof relies upon the study of a related predator–prey system with strong Allee effect on the prey.


More related to this:

Segregation distortion induced by wild-type RanGAP in Drosophila

Sperm traits of masculinized fish relative to wild-type males: a systematic review and meta-analyses

First Field Release of a Genetically Engineered, Self-Limiting Agricultural Pest Insect: Evaluating Its Potential for Future Crop Protection

Centromere-associated female meiotic drive entails male fitness costs in Monkeyflowers

An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura