Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods

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Benedict, MQB, Austin; Capurro, Margareth L.; De Barro, Paul; Handler, Alfred M.; Hayes, Keith R.; Marshall, John M.; Tabachnick, Walter J.; Adelman, Zach N.,  Vector-Borne and Zoonotic Diseases,  18:2-13. 2017.
Versatile molecular tools for creating driving transgenes and other invasive genetic factors present regulatory, ethical, and environmental challenges that should be addressed to ensure their safe use. In this article, we discuss driving transgenes and invasive genetic factors ...

X chromosome drive in a widespread Palearctic woodland fly, Drosophila testacea

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Keais, GLH, M. A.; Gowen, B. E.; Perlman, S. J.,  Journal of Evolutionary Biology,  30:1185-1194. 2017.
Selfish genes that bias their own transmission during meiosis can spread rapidly in populations, even if they contribute negatively to the fitness of their host. Driving X chromosomes provide a clear example of this type of selfish propagation. These chromosomes have important ...

Evaluating strategies for reversing CRISPR-Cas9 gene drives

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Vella, MRG, Christian E.; Lloyd, Alun L.; Gould, Fred,  Scientific Reports,  7:11038. 2017.
A gene drive biases inheritance of a gene so that it increases in frequency within a population even when the gene confers no fitness benefit. There has been renewed interest in environmental releases of engineered gene drives due to recent proof of principle experiments with the ...

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing

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Beaghton, AH, Andrew; Nolan, Tony; Crisanti, Andrea; Godfray, H. Charles J.; Burt, Austin,  Genetics,  205:1587-1596. 2017.
There is a need for new interventions against the ongoing burden of vector-borne diseases such as malaria and dengue. One suggestion has been to develop genes encoding effector molecules that block parasite development within the vector, and then use the nuclease-based homing ...

Sry gene drive for rodent control: Reply to Gemmell and Tompkins

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Kanavy, DS, M.,  Trends in Ecology & Evolution,  32:315-316. 2017.
We would like to thank Gemmell and Tompkins for their interest and comments onthe articlebyPiaggioet al. [1].Theissues raised by Gemmell and Tompkins [2] are very pertinent, and they correctly identified that the format of the article did not lend itself to a comprehensive ...

Eradicating Mosquitoes? The promise and peril of gene drive technologies.

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Jun, B-O,  Eubios Journal of Asian and International Bioethics,  27:113-116. 2017.
This paper discusses the ethical issues associated with genetic modification of mosquito species that are human disease vectors. The Oxitec genetically changed mosquito—a variant of a species called Aedes aegypti, OX513A, is taken as an example. The benefits and risks are ...

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

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Unckless, RLC, A. G.; Messer, P. W.,  Genetics,  205:827-841. 2017.
CRISPR/Cas9 gene drive (CGD) promises to be a highly adaptable approach for spreading genetically engineered alleles throughout a species, even if those alleles impair reproductive success. CGD has been shown to be effective in laboratory crosses of insects, yet it remains ...

Vector control with driving Y chromosomes: modelling the evolution of resistance

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Beaghton, AB, P. J.; Burt, A.,  Malaria Journal,  16:286. 2017.
: The introduction of new malaria control interventions has often led to the evolution of resistance, both of the parasite to new drugs and of the mosquito vector to new insecticides, compromising the efficacy of the interventions. Recent progress in molecular and population ...

A large gene family in fission yeast encodes spore killers that subvert Mendel’s law

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Hu, WJ, Z. D.; Suo, F.; Zheng, J. X.; He, W. Z.; Du, L. L.,  eLife,  6:e28567. 2017.
Spore killers in fungi are selfish genetic elements that distort Mendelian segregation in their favor. It remains unclear how many species harbor them and how diverse their mechanisms are. Here, we discover two spore killers from a natural isolate of the fission yeast ...

New Weapons in the Toad Toolkit: A Review of Methods to Control and Mitigate the Biodiversity Impacts of Invasive Cane Toads (Rhinella Marina)

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Tingley, RW-F, Georgia; Schwarzkopf, Lin; Greenlees, Matthew J.; Phillips, Benjamin L.; Brown, Gregory; Clulow, Simon; Webb, Jonathan; Capon, Robert; Sheppard, Andy; Strive, Tanja; Tizard, Mark; Shine, Richard,  The Quarterly Review of Biology,  92:123-149. 2017.
Our best hope of developing innovative methods to combat invasive species is likely to come from the study of high-profile invaders that have attracted intensive research not only into control, but also basic biology. Here we illustrate that point by reviewing current thinking ...

B Chromosomes – A matter of chromosome drive

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Houben, A,  Frontiers in Plant Science,  8:210. 2017.
B chromosomes are supernumerary chromosomes which are often preferentially inherited, deviating from usual Mendelian segregation. The balance between the so-called chromosome drive and the negative effects that the presence of Bs applies on the fitness of their host determines ...

Spatial gene drives and pushed genetic waves

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Tanaka, HS, Howard A.; Nelson, David R.,  Proceedings of the National Academy of Sciences of the United States of America,  114:8452. 2017.
Gene constructs introduced into natural environments have been proposed to solve various ecological problems. The CRISPR-Cas9 technology greatly facilitates construction of gene drives that allow desired traits to rapidly replace wild types, even if these convey a selective ...

Towards the genetic control of invasive species

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Harvey-Samuel, TA, T.; Alphey, L.,  Biological Invasions,  19:1683-1703. 2017.
Invasive species remain one of the greatest threats to global biodiversity. Their control would be enhanced through the development of more effective and sustainable pest management strategies. Recently, a novel form of genetic pest management (GPM) has been developed in which ...

Results from the Workshop “Problem Formulation for the Use of Gene Drive in Mosquitoes”

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Roberts, ADA, P. P.; Okumu, F.; Quemada, H.; Savadogo, M.; Singh, J. A.; James, S.,  American Journal of Tropical Medicine and Hygiene,  96:530-533. 2017.
Reducing the incidence of malaria has been a public health priority for nearly a century. New technologies and associated vector control strategies play an important role in the prospect of sustained reductions. The development of the CRISPR/Cas9 gene editing system has generated ...

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

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Hammond, AMK, Kyros; Bruttini, Marco; North, Ace; Galizi, Roberto; Karlsson, Xenia; Kranjc, Nace; Carpi, Francesco M.; D’Aurizio, Romina; Crisanti, Andrea; Nolan, Tony,  PLOS Genetics,  13:e1007039. 2017.
Gene drives are selfish genetic elements that are able to bias their own inheritance among offspring. Starting from very low frequencies they can rapidly invade a population in just a few generations, even when imposing a fitness cost. Gene drives based on the precise DNA cutting ...

Advances in vector control science: Rear-and-release strategies show promise… but don’t forget the basics

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Ritchie, SAJ, B. J.,  Journal of Infectious Diseases,  215:S103-S108. 2017.
Both chikungunya and Zika viruses have recently swept from Africa across the Pacific to the Americas, causing major outbreaks of disease in humans. In the meantime, dengue epidemics continue throughout the tropics. Traditional vector control programs based on strategies from ...

CRISPR-based gene drive in agriculture will face technical and governance challenges

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Gutzmann, NE, Johanna E.; Barnes, Jessica Cavin; Baltzegar, Jennifer; Jones, Michael S.; Sudweeks, Jayce,  EMBO reports,  18:1479-1480. 2017.
Comment on "Agricultural pest control with CRISPR-based gene drive: time for public debate" by Courtier-Orgogozo et al.

CRISPR/Cas9 gene drive: Growing pains for a new technology

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Reed, FA,  Genetics,  205:1037-1039. 2017.
In this commentary, Floyd Reed discusses Unckless et al. (2017),; “Evolution of resistance against CRISPR/Cas9 gene drive,”; which was published in the February issue of GENETICS.

Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs

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Gonen, SJ, J.; Gorjanc, G.; Mileham, A. J.; Whitelaw, C. B. A.; Hickey, J. M.,  Genetics Selection Evolution,  49:14. 2017.
This paper uses simulation to explore how gene drives can increase genetic gain in livestock breeding programs. Gene drives are naturally occurring phenomena that cause a mutation on one chromosome to copy itself onto its homologous chromosome. Methods: We simulated nine ...

The End of the GMO? Genome Editing, Gene Drives and New Frontiers of Plant Technology

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K. L. Hefferon and R. J. Herring,  Review of Agrarian Studies,  7. 2017.
mprovements to agriculture will constitute one of the world’s greatest challenges in the coming century. Political and social controversies, as well as complications of plant breeding, intellectual property, and regulation, have compromised the promised impact of genetically ...

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