Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Control of mosquito-borne infectious diseases: Sex and gene drive

Adelman, ZNT, Z. J.,  Trends in Parasitology,  32:219-229. 2016.
Sterile male releases have successfully reduced local populations of the dengue vector, Aedes aegypti, but challenges remain in scale and in separating sexes before release. The recent discovery of the first mosquito male determining factor (M factor) will facilitate our ...

Driven to extinction? The ethics of eradicating mosquitoes with gene-drive technologies

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Pugh, J,  Journal of Medical Ethics,  42:578-581. 2016.
Mosquito-borne diseases represent a significant global disease burden, and recent outbreaks of such diseases have led to calls to reduce mosquito populations. Furthermore, advances in gene-drive' technology have raised the prospect of eradicating certain species of mosquito via ...

Occasional recombination of a selfish X-chromosome may permit its persistence at high frequencies in the wild

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Pieper, KED, K. A.,  Journal of Evolutionary Biology,  29:2229-2241. 2016.
The sex-ratio X-chromosome (SR) is a selfish chromosome that promotes its own transmission to the next generation by destroying Y-bearing sperm in the testes of carrier males. In some natural populations of the fly Drosophila neotestacea, up to 30% of the X-chromosomes are SR ...

Gene silencing and gene drive in dengue vector control

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Paulraj, MGI, S.; Reegan, A. D.,  Indian Journal of Natural Products and Resources,  7:193-200. 2016.
Vector-borne diseases are the most feared diseases throughout the world. Mosquitoes are the prime human disease vectors as they are responsible for nearly one million human deaths every year. So they are declared as the most dangerous insects to mankind. Aedes aegypti and Ae. ...

Comparative analysis of regions with distorted segregation in three diploid populations of potato

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Manrique-Carpintero, NCC, J. J.; Veilleux, R. E.; Buell, C. R.; Douches, D. S.,  G3-Genes Genomes Genetics,  6:2617-2628. 2016.
Genes associated with gametic and zygotic selection could underlie segregation distortion, observed as alterations of expected Mendelian genotypic frequencies in mapping populations. We studied highly dense genetic maps based on single nucleotide polymorphisms to elucidate the ...

The evolutionary consequences of selfish genetic elements

Lindholm, AKP, T. A. R.,  Current Zoology,  62:655-658. 2016.
The traditional view of the genome was once that it is broadly cooperative, with all genes working together amicably to improve the success of the individual as a whole. Benefits to the individual, after all, benefit all the component genes, as fair Mendelian inheritance ensures ...

The Ecology and Evolutionary Dynamics of Meiotic Drive

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Lindholm, AKD, K. A.; Firman, R. C.; Fishman, L.; Forstmeier, W.; Holman, L.; Johannesson, H.; Knief, U.; Kokko, H.; Larracuente, A. M.; Manser, A.; Montchamp-Moreau, C.; Petrosyan, V. G.; Pomiankowski, A.; Presgraves, D. C.; Safronova, L. D.; Sutter, A.; Unckless, R. L.; Verspoor, R. L.; Wedell, N.; Wilkinson, G. S.; Price, T. A. R.,  Trends in Ecology & Evolution,  31:315-326. 2016.
Meiotic drivers are genetic variants that selfishly manipulate the production of gametes to increase their own rate of transmission, often to the detriment of the rest of the genome and the individual that carries them. This genomic conflict potentially occurs whenever a diploid ...

Stability of underdominant genetic polymorphisms in population networks

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Laruson, AJR, F. A.,  Journal of Theoretical Biology,  390:156-163. 2016.
Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either homozygote. Attention so far has mostly been ...

Pollen killer gene S35 function requires interaction with an activator that maps close to S24, another pollen killer gene in rice

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Kubo, TY, A.; Kurata, N.,  G3-Genes Genomes Genetics,  6:1459-1468. 2016.
Pollen killer genes disable noncarrier pollens, and are responsible for male sterility and segregation distortion in hybrid populations of distantly related plant species. The genetic networks and the molecular mechanisms underlying the pollen killer system remain largely ...

Mechanisms of sex determination and transmission ratio distortion in Aedes aegypti

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Hoang, KPT, T. M.; Ho, T. X.; Le, V. S.,  Parasites & Vectors,  9:49. 2016.
: More effective mosquito control strategies are urgently required due to the increasing prevalence of insecticide resistance. The sterile insect technique (SIT) and the release of insects carrying a dominant lethal allele (RIDL) are two proposed methods for ...

Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive

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Helleu, QG, P. R.; Dubruille, R.; Ogereau, D.; Prud'homme, B.; Loppin, B.; Montchamp-Moreau, C.,  Proceedings of the National Academy of Sciences of the United States of America,  113:4110-4115. 2016.
Sex chromosome meiotic drive, the non-Mendelian transmission of sex chromosomes, is the expression of an intragenomic conflict that can have extreme evolutionary consequences. However, the molecular bases of such conflicts remain poorly understood. Here, we show that a young and ...

A CRISPR-Cas9 gene drive system-targeting female reproduction in the malaria mosquito vector Anopheles gambiae

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Hammond, AG, R.; Kyrou, K.; Simoni, A.; Siniscalchi, C.; Katsanos, D.; Gribble, M.; Baker, D.; Marois, E.; Russell, S.; Burt, A.; Windbichler, N.; Crisanti, A.; Nolan, T.,  Nature Biotechnology,  34:78-83. 2016.
Gene drive systems that enable super-Mendelian inheritance of a transgene have the potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 endonuclease constructs that function as gene drive systems in Anopheles gambiae, the main vector for ...

Cas9-triggered chain ablation of cas9 as a gene drive brake

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Wu, BL, L. Q.; Gao, X. J. J.,  Nature Biotechnology,  34:137-138. 2016.
We designed and synthesized a transgene system that we named Cas9-triggered chain ablation (CATCHA). The CATCHA transgene encodes a guide RNA (gRNA) that is expressed ubiquitously from a U6:2 promoter. The gRNA targets a site within the DNA sequence of cas9. The guide RNA is ...

Putting the brakes on CRISPR-Cas9 gene drive systems

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Graham, DM,  Lab Animal,  45:47-47. 2016.
The sudden emergence and worldwide adoption of CRISPR gene-editing technology confronts humanity with unprecedented opportunities and choices. CRISPR's transformative impact on our future understanding of biology, along with its potential to unleash control over the most ...

The ability to gain matings, not sperm competition, reduces the success of males carrying a selfish genetic element in a fly

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Verspoor, RLH, G. D. D.; Price, T. A. R.,  Animal Behaviour,  115:207-215. 2016.
Females are expected to avoid low-quality males fathering their offspring. X chromosome meiotic drive (XCMD) makes males very low-quality mates. XCMDs are X chromosomes that, in males, cause the failure of all Y chromosome sperm, so all functional sperm carry the driving X and ...

The dawn of active genetics

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Gantz, VMB, E.,  Bioessays,  38:50-63. 2016.
On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What made her unique was that she had only one parent carrying a mutant allele of this classic recessive locus. Then, one generation later, after mating with a wild-type male, all her offspring ...

Meiotic drive changes sperm precedence patterns in house mice: potential for male alternative mating tactics?

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Sutter, AL, A. K.,  BMC Evolutionary Biology,  16:15. 2016.
Background: With female multiple mating (polyandry), male-male competition extends to after copulation (sperm competition). Males respond to this selective pressure through physiological, morphological and behavioural adaptations. Sperm competitiveness is commonly decreased in ...

R2d2 drives selfish sweeps in the house mouse

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Didion, JPM, A. P.; Yadgary, L.; Bell, T. A.; McMullan, R. C.; de Solorzano, L. O.; Britton-Davidian, J.; Bult, C. J.; Campbell, K. J.; Castiglia, R.; Ching, Y. H.; Chunco, A. J.; Crowley, J. J.; Chesler, E. J.; Forster, D. W.; French, J. E.; Gabriel, S. I.; Gatti, D. M.; Garland, T.; Giagia-Athanasopoulou, E. B.; Gimenez, M. D.; Grize, S. A.; Gunduz, I.; Holmes, A.; Hauffe, H. C.; Herman, J. S.; Holt, J. M.; Hua, K. J.; Jolley, W. J.; Lindholm, A. K.; Lopez-Fuster, M. J.; Mitsainas, G.; Mathias, M. D.; McMillan, L.; Ramalhinho, M. D. M.; Rehermann, B.; Rosshart, S. P.; Searle, J. B.; Shiao, M. S.; Solano, E.; Svenson, K. L.; Thomas-Laemont, P.; Threadgill, D. W.; Ventura, J.; Weinstock, G. M.; Pomp, D.; Churchill, G. A.; de Villena, F. P. M.,  Molecular Biology and Evolution,  33:1381-1395. 2016.
A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries ...

Production of a YY Male Brook Trout Broodstock for Potential Eradication of Undesired Brook Trout Populations

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D. J. Schill, J. A. Heindel, M. R. Campbell, K. A. Meyer and E. Mamer,  North American Journal of Aquaculture,  78:72-83. 2015.
Brook Trout Salvelinus fontinalis introduced outside of their native range often negatively impact native aquatic fauna or provide marginal fisheries and are frequently targeted for manual or piscicide removal in lakes and streams. Unfortunately, complete eradication of exotic ...

Stochastic models for the Trojan Y-Chromosome eradication strategy of an invasive species

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X. Y. Wang, J. R. Walton and R. D. Parshad,  Journal of Biological Dynamics,  10:179-199. 2015.
The Trojan Y-Chromosome (TYC) strategy, an autocidal genetic bio-control method, has been proposed to eliminate invasive alien species. In this work, we develop a Markov jump process model for this strategy, and we verify that there is a positive probability for wild-type females ...

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