Analysis of a general population genetic model of meiotic drive

The purpose of this article is to present the detailed solution of a model of meiotic drive which Lewontin (1968) has suggested would be helpful in understanding the evo- lutionary dynamics of the t-alleles in the house mouse. Because mice tend to breed in small endogamous family units, however, the deterministic model is only a very rough approximation to what would be expected to occur in nature, and to gain better insight one is forced to undertake Monte Carlo simulation of small populations (Lewontin and Dunn, 1960; Lewontin, 1968).