Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.

Aedes albopictus Sterile Male Production: Influence of Strains, Larval Diet and Mechanical Sexing Tools

M. Malfacini, A. Puggioli, F. Balestrino, M. Carrieri, M. L. Dindo and R. Bellini,  Insects,  2022.
The sterile insect technique (SIT) is a biologically based method of pest control, which relies on the mass production, sterilization, and release of sterile males of the target species. Since females can transmit viruses, it is important to develop a mass rearing system to ...

Distribution of sex ratio distorters in natural populations of the isopod Armadillidium vulgare

,  2022.


Externalities modulate the effectiveness of the Wolbachia release programme

E. E. Ooi and A. Wilder-Smith,  The Lancet Infectious Diseases,  2022.
Despite the remarkable outcome in Yogyakarta, the wMel approach also has some challenges. In particular, the extent to which ecological, weather, and other external factors influence the dissemination and establishment of wMel in complex urban environments remains unclear. ...

Estimating the effect of the wMel release programme on the incidence of dengue and chikungunya in Rio de Janeiro, Brazil: a spatiotemporal modelling study

G. Ribeiro dos Santos, B. Durovni, V. Saraceni, T. I. Souza Riback, S. B. Pinto, K. L. Anders, et al.,  The Lancet Infectious Diseases,  2022.
Summary Background Introgression of genetic material from species of the insect bacteria Wolbachia into populations of Aedes aegypti mosquitoes has been shown in randomised and non-randomised trials to reduce the incidence of dengue; however, evidence for the real-world ...

The Involvement of Atlastin in Dengue Virus and Wolbachia Infection in Aedes aegypti and Its Regulation by aae-miR-989

M. Hussain, T. Bradshaw, M. Lee and S. Asgari,  Microbiology Spectrum,  2022.
Endoplasmic reticulum (ER)-shaping atlastin proteins (ATLs) have been demonstrated to play a functional role during flavivirus replication in mammalian cells. For dengue virus (DENV), atlastin is required in the formation of the replication organelles and RNA replication, virion ...

Wolbachia action in the sperm produces developmentally deferred chromosome segregation defects during the Drosophila mid-blastula transition

B. Warecki, S. W. A. Titen, M. S. Alam, G. Vega, N. Lemseffer, K. Hug, et al.,  eLife,  11:e81292. 2022.
Wolbachia, a vertically transmitted endosymbiont infecting many insects, spreads rapidly through uninfected populations by a mechanism known as cytoplasmic incompatibility (CI). In CI, a paternally delivered modification of the sperm leads to chromatin defects and lethality ...

Meiotic drive is associated with sexual incompatibility in Neurospora

A. Vogan, J. Svedberg, M. Grudzinska-Sterno and H. Johannesson,  Evolution,  2022.
Evolution of Bateson-Dobzhansky-Muller (BDM) incompatibilities is thought to represent a key step in the formation of separate species. They are incompatible alleles that have evolved in separate populations and are exposed in hybrid offspring as hybrid sterility or lethality. In ...

Wolbachia strain wAlbB remains stable in Aedes aegypti over 15 years but exhibits genetic background-dependent variation in virus blocking

X. Liang, C. H. Tan, Q. Sun, M. Zhang, P. J. Wong, M. I. Li, et al.,  PNAS Nexus,  2022.
The ability of the maternally transmitted endosymbiotic bacterium Wolbachia to induce cytoplasmic incompatibility (CI) and virus blocking makes it a promising weapon for combatting mosquito-borne diseases through either suppression or replacement of wild-type populations. Recent ...

Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development

Hoermann, Astrid, Habtewold, Tibebu, Selvaraj, Prashanth, Del Corsano, Giuseppe, Capriotti, Paolo, Inghilterra, Maria Grazia, Kebede, Temesgen M., Christophides, George K. and Windbichler, Nikolai,  Science Advances,  2022.
Gene drives hold promise for the genetic control of malaria vectors. The development of vector population modification strategies hinges on the availability of effector mechanisms impeding parasite development in transgenic mosquitoes. We augmented a midgut gene of the malaria ...

Daisy-chain gene drives: The role of low cut-rate, resistance mutations, and maternal deposition

S. A. N. Verkuijl, M. A. E. Anderson, L. Alphey and M. B. Bonsall,  PLOS Genetics,  18:e1010370. 2022.
Author summary Reducing the harm of pest species by the introgression of traits into a wild population is often limited by the difficulties of mass rearing and release of modified individuals. Gene drives present an opportunity to substantially reduce the release frequencies ...

Genome sequencing and comparative analysis of Wolbachia strain wAlbA reveals Wolbachia-associated plasmids are common

J. Martinez, T. H. Ant, S. M. Murdochy, L. Tong, A. da Silva Filipe and S. P. Sinkins,  PLOS Genetics,  18:e1010406. 2022.
Wolbachia is the most common bacterial symbiont of arthropods, being found in about half of terrestrial species around the globe. It is transmitted from mother to offspring, can spread rapidly by inducing various forms of reproductive parasitism and often provides protection ...

Meiotic drive does not impede success in sperm competition in the stalk-eyed fly, Teleopsis dalmanni

S. Bates, L. Meade and A. Pomiankowski,  bioRxiv,  2022.
Meiotic drive genes are selfish genetic elements that distort Mendelian patterns of inheritance to bias transmission in their favour. We use the stalk-eyed fly, Teleopsis dalmanni, to investigate the fitness effects associated with a meiotic drive gene called Sex Ratio (SR), ...

Enforcement of Postzygotic Species Boundaries in the Fungal Kingdom

J. Y. Chou, P. C. Hsu and J. Y. Leu,  Microbiology and Molecular Biology Reviews,  2022.
Understanding the molecular basis of speciation is a primary goal in evolutionary biology. The formation of the postzygotic reproductive isolation that causes hybrid dysfunction, thereby reducing gene flow between diverging populations, is crucial for speciation. Using various ...

Quality control traceability during the packing and release process of Ceratitis capitata for sterile insect technique

Y. Contreras-Navarro, H. Luis-Alvarez, G. García-Coapio, R. Hernández, S. Flores and P. Montoya,  Journal of Applied Entomology,  2022.
Abstract In programmes applying the sterile insect technique (SIT), the quality of insects deployed in the field determines the success in preventing, suppressing, containing or eradicating the pest population. In the fruit fly emergence and release facility (ERF) of the Moscamed ...

Transposable elements

A. Hayward and C. Gilbert,  Current Biology,  32:R904-r909. 2022.
Transposable elements are known by many names, including 'transposons', 'interspersed repeats', 'selfish genetic elements', 'jumping genes', and 'parasitic DNA', but here we will refer to them simply as transposable elements. Many biologists will have heard of transposable ...

Selfish evolution of placental hormones

G. Keegan and M. M. Patten,  Evolution, Medicine, and Public Health,  10:391-397. 2022.
We hypothesize that some placental hormones—specifically those that arise by tandem duplication of genes for maternal hormones—may behave as gestational drivers, selfish genetic elements that encourage the spontaneous abortion of offspring that fail to inherit them. Such ...

Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity

C. Bishop, M. Hussain, L. E. Hugo and S. Asgari,  Scientific Reports,  12:15245. 2022.
The mosquito Aedes aegypti is the primary vector of a range of medically important viruses including dengue, Zika, West Nile, yellow fever, and chikungunya viruses. The endosymbiotic bacterium Wolbachia pipientis wAlbB strain is a promising biocontrol agent for blocking viral ...

A detailed landscape of CRISPR-Cas-mediated plant disease and pest management

S. Karmakar, P. Das, D. Panda, K. Xie, M. J. Baig and K. A. Molla,  Plant Science,  323:111376. 2022.
Genome editing technology has rapidly evolved to knock-out genes, create targeted genetic variation, install precise insertion/deletion and single nucleotide changes, and perform large-scale alteration. The flexible and multipurpose editing technologies have started playing a ...

On the Mechanistic Basis of Killer Meiotic Drive in Fungi

S. J. Saupe and H. Johannesson,  Annual Review of Microbiology,  76:305-323. 2022.
Spore killers are specific genetic elements in fungi that kill sexual spores that do not contain them. A range of studies in the last few years have provided the long-awaited first insights into the molecular mechanistic aspects of spore killing in different fungal models, ...

Life-history traits of a fluorescent Anopheles arabiensis genetic sexing strain introgressed into South African genomic background

N. L. Ntoyi, T. Mashatola, J. Bouyer, C. Kraupa, H. Maiga, W. Mamai, N. S. Bimbile-Somda, T. Wallner, D. O. Carvalho, G. Munhenga and H. Yamada,  Malaria Journal,  21:12. 2022.
Background South Africa has set a mandate to eliminate local malaria transmission by 2023. In pursuit of this objective a Sterile Insect Technique programme targeting the main vector Anopheles arabiensis is currently under development. Significant progress has been made towards ...
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