Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.

Bayesian network-based risk assessment of synthetic biology: Simulating CRISPR-Cas9 gene drive dynamics in invasive rodent management

E. A. Brown, S. R. Eikenbary and W. G. Landis,  Risk Analysis,  2022.
Gene drive technology has been proposed to control invasive rodent populations as an alternative to rodenticides. However, this approach has not undergone risk assessment that meets criteria established by Gene Drives on the Horizon, a 2016 report by the National Academies of ...
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Aquatic invasive species specialists’ perceptions on the importance of genetic tools and concepts to inform management

T. A. Bernos, K. M. Jeffries and N. E. Mandrak,  Biological Invasions,  24:1863-1879. 2022.
Perceptions related to the importance of genetic research influence the mobilization of genetic tools and concepts to inform conservation actions. Research characteristics, stakeholders’ perspectives, knowledge, and social linkages with geneticists influence the outcome of ...
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Simple, sensitive, and cost-effective detection of wAlbB Wolbachia in Aedes mosquitoes, using loop mediated isothermal amplification combined with the electrochemical biosensing method

P. Thayanukul, B. Lertanantawong, W. Sirawaraporn, S. Charasmongkolcharoen, T. Chaibun, R. Jittungdee and P. Kittayapong,  PLOS Neglected Tropical Diseases,  16:e0009600. 2022.
Author summary Mosquito-borne diseases such as dengue, chikungunya, zika, and yellow fever are transmitted to humans mainly by the bites of Aedes aegypti mosquitoes. Controlling the vectors of these diseases relies mostly on the use of insecticides. However, the efficiency has ...
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Intronic gRNAs for the Construction of Minimal Gene Drive Systems

A. Nash, P. Capriotti, A. Hoermann, P. A. Papathanos and N. Windbichler,  Frontiers in Bioengineering and Biotechnology,  10. 2022.
Gene drives are promising tools for the genetic control of insect vector or pest populations. CRISPR-based gene drives are generally highly complex synthetic constructs consisting of multiple transgenes and their respective regulatory elements. This complicates the generation of ...
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Lessons learned from the introduction of genetically engineered crops: relevance to gene drive deployment in Africa

H. Quemada,  Transgenic Res,  2022.
The application of gene drives to achieve public health goals, such as the suppression of Anopheles gambiae populations, or altering their ability to sustain Plasmodium spp. infections, has received much attention from researchers. If successful, this genetic tool can contribute ...
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The effect of mating complexity on gene drive dynamics

P. Verma, R. G. Reeves, S. Simon, M. Otto and C. S. Gokhale,  bioRxiv,  2021.09.16.460618. 2022.
Gene drive technology promises to deliver on some of the global challenges humanity faces today in healthcare, agriculture and conservation. However, there is a limited understanding of the consequences of releasing self-perpetuating transgenic organisms into the wild populations ...
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Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles

A. L. Bishop, V. López Del Amo, E. M. Okamoto, Z. Bodai, A. C. Komor and V. M. Gantz,  Nat Commun,  13:2595. 2022.
Homing CRISPR gene drives could aid in curbing the spread of vector-borne diseases and controlling crop pest and invasive species populations due to an inheritance rate that surpasses Mendelian laws. However, this technology suffers from resistance alleles formed when the ...
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Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models

Y. Liu, W. Teo, H. Yang and J. Champer,  bioRxiv,  2022.05.08.491087. 2022.
Suppression gene drives are designed to bias their inheritance and increase in frequency in a population, disrupting an essential gene in the process. When the frequency is high enough, the population will be unable to reproduce above the replacement level and could be ...
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Local adaptation of Aedes aegypti mosquitoes to Wolbachia-induced fitness costs

P. A. Ross and A. A. Hoffmann,  bioRxiv,  2022.05.06.490959. 2022.
Aedes aegypti mosquito eggs can remain quiescent for many months before hatching, allowing populations to persist through unfavorable conditions. Aedes aegypti infected with the Wolbachia strain wMel have been released in tropical and subtropical regions for dengue control. wMel ...
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The principles driving gene drives for conservation

S. Hartley, R. Taitingfong and P. Fidelman,  Environmental Science and Policy,  135:36-45. 2022.
Gene drive technology is an emerging biotechnology with the potential to address some of the most intractable global biodiversity conservation issues. Scientists are exploring potential gene drive applications for managing invasive species and building resilience in keystone ...
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New weapons to fight malaria transmission: A historical view

W. Huang, S.-J. Cha and M. Jacobs-Lorena,  Entomological Research,  2022.
The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of ...
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Epistatic selection on a selfish Segregation Distorter supergene: drive, recombination, and genetic load

B. Navarro-Dominguez, C.-H. Chang, C. L. Brand, C. A. Muirhead, D. C. Presgraves and A. M. Larracuente,  eLife,  11:e78981. 2022.
In this work, we investigate the evolution and genomic consequences of an autosomal, multilocus, male meiotic drive system, Segregation Distorter (SD) in the fruit fly, Drosophila melanogaster. In African populations, the predominant SD chromosome variant, SD-Mal, is ...
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Engineering a self-eliminating transgene in the yellow fever mosquito, Aedes aegypti

K. Chae, C. Dawson, C. Valentin, B. Contreras, J. Zapletal, K. M. Myles and Z. N. Adelman,  PNAS Nexus,  2022.
Promising genetics-based approaches are being developed to reduce or prevent the transmission of mosquito-vectored diseases. Less clear is how such transgenes can be removed from the environment, a concern that is particularly relevant for highly invasive gene drive transgenes. ...
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A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives

M. I. Tek and K. Budak,  Frontiers in Plant Science,  13. 2022.
CRISPR drive is a recent and robust tool that allows durable genetic manipulation of the pest population like human disease vectors such as malaria vector mosquitos. In recent years, it has been suggested that CRISPR drives can also be used to control plant diseases, pests, and ...
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Pilot trial using mass field-releases of sterile males produced with the incompatible and sterile insect techniques as part of integrated Aedes aegypti control in Mexico

A. Martín-Park, A. Che-Mendoza, Y. Contreras-Perera, S. Pérez-Carrillo, H. Puerta-Guardo, J. Villegas-Chim, G. Guillermo-May, A. Medina-Barreiro, H. Delfín-González, R. Méndez-Vales, S. Vázquez-Narvaez, J. Palacio-Vargas, F. Correa-Morales, G. Ayora-Tal,  PLoS Negl Trop Dis,  16:e0010324. 2022.
We implemented a controlled before-and-after quasi-experimental study in two suburban localities of Yucatan (Mexico): San Pedro Chimay (SPC), which received IIT-SIT, and San Antonio Tahdzibichén used as control. Release of wAlbB Ae. aegypti males at SPC extended for 6 months ...
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Recent advancements in CRISPR/Cas technology for accelerated crop improvement

D. Das, D. L. Singha, R. R. Paswan, N. Chowdhury, M. Sharma, P. S. Reddy and C. Chikkaputtaiah,  Planta,  255:109. 2022.
The likelihood of reduced agricultural production due to highly turbulent climatic conditions increases as the global population expands. The second paradigm of stress-resilient crops with enhanced tolerance and increased productivity against various stresses is paramount to ...
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Biotechnological Road Map for Innovative Weed Management

A. C. S. Wong, K. Massel, Y. Lam, J. Hintzsche and B. S. Chauhan,  Frontiers in Plant Science,  13. 2022.
In most agriculture farmlands, weed management is predominantly reliant on integrated weed management (IWM) strategies, such as herbicide application. However, the overuse and misuse of herbicides, coupled with the lack of novel active ingredients, has resulted in the uptrend of ...
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The evolutionary significance of meiotic drive

J. B. Searle and F. P.-M. de Villena,  Heredity,  2022.
In this essay, we will focus on‘true meiotic drive’ where the distorted transmission does arise within meiosis itself (Zanders and Unckless2019),specifically in females. Here, the non-transmission of one of the products of meiotic division is inherent in the gametogenic ...
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Experimental demonstration of tethered gene drive systems for confined population modification or suppression

M. Metzloff, E. Yang, S. Dhole, A. G. Clark, P. W. Messer and J. Champer,  bioRxiv,  2021.05.29.446308. 2022.
Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This could represent a substantial sociopolitical ...
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Role of CRISPR Technology in Gene Editing of Emerging and Re-emerging Vector Borne Disease

K. K. Mahto, P. Prasad, M. Kumar, H. Dubey and A. Ranjan,  Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies,  2022.
Vector borne diseases are rampant across the world. Due to spread and estab-lishment of vector species in different geographical areas, vector adaptation and resistance towards many insecticides the only option left is vector control for vari-ous vector borne diseases. Recent ...
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