Scholarly Literature
This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives). The latest are shown here.
Disclaimer>
Acceptability of emergent Aedes aegypti vector control methods in Ponce, Puerto Rico: A qualitative assessmentPérez-Guerra CL, Rosado-Santiago C, Ramos SA, Marrero-Santos KM, González-Zeno G, Partridge SK, et al., PLoS Global Public Health, 2024.Aedes aegypti control has been fraught with challenges in Puerto Rico. The government has implemented commonly used vector control methods, but arboviral epidemics still occur. It is necessary to explore new Ae. aegypti control methods. This study aimed to understand the ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Efficacy of Wolbachia-based mosquito control: Predictions of a spatially discrete mathematical modelDavid Dye, John W. Cain, PLoS One, 19. 2024.Wolbachia is an endosymbiont bacterium present in many insect species. When Wolbachia-carrying male Aedes aegypti mosquitoes mate with non-carrier females, their embryos are not viable due to cytoplasmic incompatibility. This phenomenon has been exploited successfully for the ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Aedes aegypti Controls Ae. aegypti: SIT and IIT—An OverviewRobert L. Aldridge; Seth Gibson; Kenneth J. Linthicum, Journal of the American Mosquito Control Association, 20:32-49. 2024.The sterile insect technique (SIT) and the incompatible insect technique (IIT) are emerging and potentially revolutionary tools for controlling Aedes aegypti (L.), a prominent worldwide mosquito vector threat to humans that is notoriously difficult to reduce or eliminate in ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
DENV-1 Titer Impacts Viral Blocking in wMel Aedes aegypti with Brazilian Genetic BackgroundCorrêa-Antônio, Jessica, Mariana R. David, Dinair Couto-Lima, Gabriela Azambuja Garcia, Milan S. G. Keirsebelik, Rafael Maciel-de-Freitas, and Márcio Galvão Pavan., Viruses, 16. 2024.Several countries have been using Wolbachia deployments to replace highly competent native Aedes aegypti populations with Wolbachia-carrying mosquitoes with lower susceptibility to arboviruses such as dengue, Zika, and chikungunya. In Rio de Janeiro, Wolbachia deployments started ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Effectiveness evaluation of mosquito suppression strategies on dengue transmission under changing temperature and precipitationKaihui Liu, Shuanghui Fang, Qiong Li, et al., Acta Tropica, 2024.Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
PSRs: Selfish chromosomes that manipulate reproductive developmentXinmi Zhang, Patrick M. Ferree, Seminars in Cell and Developmental Biology, 159-160:66-73. 2024.B chromosomes are intriguing “selfish” genetic elements, many of which exhibit higher-than-Mendelian transmission. This perspective highlights a group of B chromosomes known as Paternal Sex Ratio chromosomes (PSRs), which are found in several insects with haplo-diploid ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Un1Cas12f1 and Cas9 gene drive in HSV1: viruses that ‘infect’ virusesQiaorui Yao, Zhuangjie Lin, Keyuan Lai, Xianying Zeng, Guanxiong Lei, Tongwen Zhang, Hongsheng Dai, bioRxiv, 2024.Synthetic CRISPR-Cas9 gene drive has been developed as a potential tool to control harmful species. However, Cas9 gene drive faces high resistance rate and mitigation strategies developed so far are difficult to implement. Furthermore, studying the resistance to gene drive is ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
CRISPR-mediated germline mutagenesis for genetic sterilization of Anopheles gambiae malesSmidler, A.L., Marrogi, E., Kauffman, J. et al., Scientific Reports, 14. 2024.Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria elimination efforts, necessitating development of alternative vector control technologies. Sterile insect technique (SIT) has been successfully implemented in multiple insect pests to suppress ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Efficacy of Wolbachia-mediated sterility to reduce the incidence of dengue: a synthetic control study in SingaporeJue Tao Lim, Somya Bansal*, Chee Seng Chong*, Borame Dickens, Youming Ng, Lu Deng, Caleb Lee, Li Yun Tan, Grace Chain, Pei Ma, Shuzhen Sim, Cheong Huat Tan, Alex R Cook, Lee Ching Ng, The Lancet Microbe, 2024.Our study comprised an at-risk population of 607 872 individuals living in intervention sites and 3 894 544 individuals living in control sites. Interventions demonstrated up to 77·28% (121/156, 95% CI 75·81–78·58) intervention efficacy despite incomplete coverage ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Acetylcholine esterase of Drosophila melanogaster: a laboratory model to explore insecticide susceptibility gene drivesHernandes, N., Qi, X.M., Bhide, S., Brown, C., Camm, B.J., Baxter, S.W. and Robin, C., Pest Management Science, 2024.One of the proposed applications of gene drives has been to revert pesticide resistant mutations back to the ancestral susceptible state. Insecticides that have become ineffective because of the rise of resistance could have reinvigorated utility and be used to suppress pest ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Introduction of Aedes aegypti mosquitoes carrying wAlbB Wolbachia sharply decreases dengue incidence in disease hotspotsAA Hoffmann, NW Ahmad, WM Keong, CY Ling, NA Ahmad, N. Golding, N. Tierney, J. Jelip, PW Putit, N Mohktar, SS Sandhu, LS Ming, et al., iScience, 2024.Partial replacement of resident Aedes aegypti mosquitoes with introduced mosquitoes carrying certain strains of inherited Wolbachia symbionts can result in transmission blocking of dengue and other viruses of public health importance. Wolbachia strain wAlbB is an effective ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene driveLawler, Clancy D ,Parra Nuñez, Ana Karla ,Hernandes, Natalia ,Bhide, Soumitra ,Lohrey, Isabelle ,Baxter, Simon ,Robin, Charles, G3 Genes Genome Genetics, jkae025. 2024.We examine this ‘X-poisoning’ strategy by targeting four of the 11 known X-linked haplolethal/haplosterile genes of Drosophila melanogaster with CRISPR/Cas9. We find that targeting the wupA gene during spermatogenesis skews the sex ratio so fewer than 14% of progeny are ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Genome editing in pests: basic science to applicationsChen, X., Palli, S.R., Journal of Pest Science, 2024.Recent developments in sequencing technologies produced enormous data on gene sequences and the identity of genes in many pest insects and disease vectors. However, the function of many of these genes is unknown. Functional genomics studies to uncover gene function in pest ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Deep orange gene editing triggers temperature-sensitive lethal phenotypes in Ceratitis capitataSollazzo, G., Nikolouli, K., Gouvi, G. et al., BMC Biotechnology, 24. 2024.The Mediterranean fruit fly, Ceratitis capitata, is a significant agricultural pest managed through area-wide integrated pest management (AW-IPM) including a sterile insect technique (SIT) component. Male-only releases increase the efficiency and cost-effectiveness of SIT ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cagesD’Amato, R., Taxiarchi, C., Galardini, M. et al., Nature Communications, 15:952. 2024.CRISPR-based gene drives have the potential to spread within populations and are considered as promising vector control tools. A doublesex-targeting gene drive was able to suppress laboratory Anopheles mosquito populations in small and large cages, and it is considered for field ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Meiotic drive against chromosome fusions in butterfly hybridsJesper Boman, Christer Wiklund, Roger Vila, Niclas Backström, bioRxiv, 2024.Species frequently differ in karyotype, but heterokaryotypic individuals may suffer from reduced fitness. Chromosomal rearrangements like fissions and fusions can thus serve as a mechanism for speciation between incipient lineages but their evolution poses a paradox. How does ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Intra-lineage microevolution of Wolbachia leads to the emergence of new cytoplasmic incompatibility patternsNamias A, Ngaku A, Makoundou P, Unal S, Sicard M, Weill M, PLoS Biology, 2024.Mosquitoes of the Culex pipiens complex are worldwide vectors of arbovirus, filarial nematodes, and avian malaria agents. In these hosts, the endosymbiotic bacteria Wolbachia induce cytoplasmic incompatibility (CI), i.e., reduced embryo viability in so-called incompatible ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Targeting sex determination to suppress mosquito populationsMing Li, Nikolay P Kandul,Ruichen Sun, Ting Yang, Elena D Benetta, Daniel J Brogan, Igor Antoshechkin, Héctor M Sánchez C, Yinpeng Zhan, Nicolas A DeBeaubien, YuMin M Loh, Matthew P Su, Craig Montell, John M Marshall, Omar S Akbari, eLife, 12. 2024.Each year, hundreds of millions of people are infected with arboviruses such as dengue, yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious mosquito Aedes aegypti. Traditional control measures have proven insufficient, necessitating innovations. ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegyptiMcNamara, C.J., Ant, T.H., Harvey-Samuel, T. et al., Nature Communications, 15. 2024.The endosymbiotic bacteria Wolbachia can invade insect populations by modifying host reproduction through cytoplasmic incompatibility (CI), an effect that results in embryonic lethality when Wolbachia-carrying males mate with Wolbachia-free females. Here we describe a transgenic ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
|
Transforming malaria prevention and control: the prospects and challenges of gene drive technology for mosquito managementYusuf Amuda Tajudeen, Habeebullah Jayeola Oladipo, Iyiola Olatunji Oladunjoye, Muhammad Kamaldeen Oladipo, Hameedat Damilola Shittu, Imam-Fulani Abdulmumeen, Abdullateef Opeyemi Afolabi and Mona Said El-Sherbini, Annals of Medicine, 55. 2024.In the era of insecticides and anti-malarial drug resistance, gene drive technology holds considerable promise for malaria control. Gene drive technology deploys genetic modifications into mosquito populations to impede their ability to transmit the malaria parasite. This can be ... Keywords: Aedes aegypti, genetically modified mosquitoes, vector control, wolbachia |
Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
RSS