Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.

Assessing CRISPR/Cas9 potential in SDG3 attainment: malaria elimination—regulatory and community engagement landscape

Snuzik, A.,  Malaria Journal,  23. 2024.
Elimination of malaria has become a United Nations member states target: Target 3.3 of the sustainable development goal no. 3 (SDG3). Despite the measures taken, the attainment of this goal is jeopardized by an alarming trend of increasing malaria case incidence. Globally, there ...
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Programming tumor evolution with selection gene drives to proactively combat drug resistance

Leighow, S.M., Reynolds, J.A., Sokirniy, I. et al.,  Nature Biotechnology,  2024.
Most targeted anticancer therapies fail due to drug resistance evolution. Here we show that tumor evolution can be reproducibly redirected to engineer therapeutic opportunity, regardless of the exact ensemble of pre-existing genetic heterogeneity. We develop a selection gene ...
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Revisiting Wolbachia detections: Old and new issues in Aedes aegypti mosquitoes and other insects

Perran A. Ross, Ary A. Hoffmann,  Ecology and Evolution,  14. 2024.
Wolbachia continue to be reported in species previously thought to lack them, particularly Aedes aegypti mosquitoes. The presence of Wolbachia in this arbovirus vector is considered important because releases of mosquitoes with transinfected Wolbachia are being used around the ...
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Economic optimization of Wolbachia-infected Aedes aegypti release to prevent dengue

Brandon D. Hollingsworth, Chanheung Cho, Michael Vella, Hyeongyul Roh, Julian Sass, Alun L. Lloyd, Zachary S. Brown,  Pest Management Science,  80:3829-3838. 2024.
Dengue virus, primarily transmitted by the Aedes aegypti mosquito, is a major public health concern affecting ≈3.83 billion people worldwide. Recent releases of Wolbachia-transinfected Ae. aegypti in several cities worldwide have shown that it can reduce dengue ...
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Mark–Release–Recapture (MRR) of Sterile Male Aedes albopictus (Skuse) in Sri Lanka: Field Performance of Sterile Males and Estimation of the Wild Mosquito Population Density

Hapugoda, Menaka, Nilmini Silva Gunawardena, Tharaka Ranathunge, Jeremy Bouyer, Hamidou Maiga, Kankanige Karunathilake, Gayan Parakrama Withanage, Indika Weerasinghe, Bazoumana B. D. Sow, and Jeevanie Harishchandra,  Insects,  15:466. 2024.
Dengue is an important mosquito-borne disease in Sri Lanka. The Sterile Insect Technique (SIT) is an environment-friendly and novel method that can suppress dengue vector mosquitoes in Sri Lanka. This study aimed to evaluate the field performance of sterile males and the density ...
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No Such Thing as Containment? Gene Drives for Conservation and the (Im)possibility of an Island

Boersma, K., Bovenkerk, B. and Ludwig, D.,  Philosophy and Technology,  37:75. 2024.
This article explores the use of islands as tools of geographical and intellectual containment - or what we call “islanding” - in the scientific and policy literature about gene drive technologies in conservation. In the first part of the article, we explore the narrative of ...
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Escalation of genome defense capacity enables control of an expanding meiotic driver

Peiwei Chen, Katherine C. Pan, Eunice H. Park, Yicheng Luo, Yuh Chwen G. Lee, Alexei A. Aravin,  bioRxiv,  2024.
From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity1,2. Despite their diversity, different defense pathways share a modular organization, where numerous specificity factors identify diverse ...
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Modeling the Evolution of S. pombe Populations with Multiple Killer Meiotic Drivers

José Fabricio López Hernández, Boris Y Rubinstein, Robert L Unckless, Sarah E Zanders,  G3 Genes|Genomes|Genetics,  2024.
Meiotic drivers are selfish genetic loci that can be transmitted to more than half of the viable gametes produced by a heterozygote. This biased transmission gives meiotic drivers an evolutionary advantage that can allow them to spread over generations until all members of a ...
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Exploration of the potential of a boosted sterile insect technique to control fruit flies in mango orchards

Esther Gnilane Diouf, Thierry Brévault, Saliou Ndiaye, Cyril Piou,  Pest Management Science,  2024.
An innovative version of the sterile insect technique (SIT) for pest control, called boosted SIT, relies on the use of sterile males coated with a biocide to control a target wild pest population of the same species. The objective of the present study was to assess the relevance ...
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Eliminating malaria vectors with precision-guided sterile males

Reema A. Apte, Andrea L. Smidler, James J. Pai, et al,  Applied Biological Sciences,  121. 2024.
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is considered essential to curtail malaria transmission. However, existing vector control technologies rely on insecticides, which are becoming increasingly ineffective. Sterile insect technique ...
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MGDrivE 3: A decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillance

Mondal A, Sánchez C. HM, Marshall JM,  PLoS Computational Biology,  20. 2024.
Novel mosquito genetic control tools, such as CRISPR-based gene drives, hold great promise in reducing the global burden of vector-borne diseases. As these technologies advance through the research and development pipeline, there is a growing need for modeling frameworks ...
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Germline Cas9 promoters with improved performance for homing gene drive

Du, J., Chen, W., Jia, X. et al.,  Nature Communications,  15:4560. 2024.
Gene drive systems could be a viable strategy to prevent pathogen transmission or suppress vector populations by propagating drive alleles with super-Mendelian inheritance. CRISPR-based homing gene drives convert wild type alleles into drive alleles in heterozygotes with Cas9 and ...
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Upscaling irradiation protocols of Aedes albopictus pupae within an SIT program in Reunion Island

Marquereau, L., Yamada, H., Damiens, D. et al.,  Scientific Reports,  14. 2024.
The implementation of the sterile insect technique against Aedes albopictus relies on many parameters, in particular on the success of the sterilization of males to be released into the target area in overflooding numbers to mate with wild females. Achieving consistent sterility ...
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Curing mosquitoes with genetic approaches for malaria control

Mary Kefi, Victor Cardoso-Jaime, Sally A. Saab, George Dimopoulos,  Trends in Parasitology,  2024.
Malaria remains a persistent global public health challenge because of the limitations of current prevention tools. The use of transgenic mosquitoes incapable of transmitting malaria, in conjunction with existing methods, holds promise for achieving elimination of malaria and ...
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Transformation of meiotic drive into hybrid sterility in Drosophila

Jackson Bladen, Hyuck-Jin Nam, Nitin Phadnis,  bioRxiv,  2024.
Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, ...
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A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae

Ignacio Tolosana, Katie Willis, Austin Burt, Matthew Gribble, Tony Nolan, Andrea Crisanti, Federica Bernardini,  bioRxiv,  2024.
Genetic control – the deliberate introduction of genetic traits to control a pest or vector population – offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of ...
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A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii

Ma S, Ni X, Chen S, Qiao X, Xu X, Chen W, et al.,  PLoS Genetics,  2024.
CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests. A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles. One approach to mitigate the development of ...
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Wolbachia symbionts control sex in a parasitoid wasp using a horizontally acquired gene

Li C, Li CQ, Chen ZB, Liu BQ, Sun X, Wei KH, Li CY, Luan JB.,  Current Biology,  2024.
Host reproduction can be manipulated by bacterial symbionts in various ways. Parthenogenesis induction is the most effective type of reproduction manipulation by symbionts for their transmission. Insect sex is determined by regulation of doublesex (dsx) splicing through ...
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Meiotic drive against chromosome fusions in butterfly hybrids

Boman, J., Wiklund, C., Vila, R. et al.,  Chromosome Research,  32. 2024.
Species frequently differ in the number and structure of chromosomes they harbor, but individuals that are heterozygous for chromosomal rearrangements may suffer from reduced fitness. Chromosomal rearrangements like fissions and fusions can hence serve as a mechanism for ...
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Genetic and geographic population structure in the malaria vector, Anopheles farauti, provides a candidate system for pioneering confinable gene-drive releases

Ambrose, L., Allen, S.L., Iro’ofa, C. et al.,  Heredity,  132:232-246. 2024.
Indoor insecticide applications are the primary tool for reducing malaria transmission in the Solomon Archipelago, a region where Anopheles farauti is the only common malaria vector. Due to the evolution of behavioural resistance in some An. farauti populations, these ...
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