Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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The suppressive potential of a gene drive in populations of invasive social wasps is currently limited

A. B. Meiborg, N. R. Faber, B. A. Taylor, B. A. Harpur and G. Gorjanc,  Scientific Reports,  13:1640. 2023.
Social insects are very successful invasive species, and the continued increase of global trade and transportation has exacerbated this problem. The yellow-legged hornet, Vespa velutina nigrithorax (henceforth Asian hornet), is drastically expanding its range in Western Europe. ...
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Engineered Antiviral Sensor Targets Infected Mosquitoes

E. Dalla Benetta, A. J. Lopez-Denman, H.-H. Li, R. A. Masri, D. J. Brogan, M. Bui, T. Yang, M. Li, M. Dunn, M. J. Klein, S. Jackson, K. Catalan, K. R. Blasdell, P. Tng, I. Antoshechkin, L. S. Alphey, P. N. Paradkar and O. Akbari,  bioRxiv,  2023.01.27.525922. 2023.
Escalating vector disease burdens pose significant global health risks, so innovative tools for targeting mosquitoes are critical. We engineered an antiviral strategy termed REAPER (vRNA Expression Activates Poisonous Effector Ribonuclease) that leverages the programmable ...
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Impact of randomised wmel Wolbachia deployments on notified dengue cases and insecticide fogging for dengue control in Yogyakarta City

C. Indriani, S. K. Tanamas, U. Khasanah, M. R. Ansari, Rubangi, W. Tantowijoyo, R. A. Ahmad, S. M. Dufault, N. P. Jewell, A. Utarini, C. P. Simmons and K. L. Anders,  Glob Health Action,  16:2166650. 2023.
BACKGROUND: Releases of Wolbachia (wMel)-infected Aedes aegypti mosquitoes significantly reduced the incidence of virologically confirmed dengue in a previous cluster randomised trial in Yogyakarta City, Indonesia. Following the trial, wMel releases were extended to the untreated ...
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Control of Aedes mosquito populations using recombinant microalgae expressing short hairpin RNAs and their effect on plankton

X. Fei, S. Xiao, X. Huang, Z. Li, X. Li, C. He, Y. Li, X. Zhang and X. Deng,  PLOS Neglected Tropical Diseases,  17:e0011109. 2023.
New biocontrol strategies are urgently needed to combat vector-borne infectious diseases. This study presents a low-cost method to produce a potential mosquito insecticide that utilizes the microalgae released into suburban water sources to control mosquito populations. Chlorella ...
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Assessing potential hybridization between a hypothetical gene drive-modified Drosophila suzukii and nontarget Drosophila species

S. Wolf, J. Collatz, J. Enkerli, F. Widmer and J. Romeis,  Risk Analysis,  2023.
Genetically engineered gene drives (geGD) are potentially powerful tools for suppressing or even eradicating populations of pest insects. Before living geGD insects can be released into the environment, they must pass an environmental risk assessment to ensure that their release ...
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Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study

J. Li and J. Champer,  PLOS Genetics,  19:e1010591. 2023.
Wolbachia are maternally-inherited bacteria, which can spread rapidly in populations by manipulating reproduction. cifA and cifB are genes found in Wolbachia phage that are responsible for cytoplasmic incompatibility, the most common type of Wolbachia reproductive interference. ...
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Complicated expansion trajectories of insertion sequences and potential association with horizontal transfer of Wolbachia DNA

Y. H. Miao, D. W. Huang and J. H. Xiao,  Zoological Research,  44:273-275. 2023.
Insertion sequences (ISs) are the simplest structural transposable elements (TEs) in prokaryotes, consisting only of a transposase coding sequence and its bilateral short terminal inverted repeats. Due to their gradually streamlined genomic construction, TEs rarely exist in the ...
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Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements

M. A. E. Anderson, E. Gonzalez, J. X. D. Ang, L. Shackleford, K. Nevard, S. A. N. Verkuijl, M. P. Edgington, T. Harvey-Samuel and L. Alphey,  Nature Communications,  14:338. 2023.
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to mosquito control. While attempts have been made to develop such systems in Aedes aegypti, none have been able to match the high drive efficiency observed in Anopheles species. Here we generate Ae. ...
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Joint FAO/IAEA Coordinated Research Project on Mosquito Handling, Transport, Release and Male Trapping Methods in Support of SIT Application to Control Mosquitoes

M. Gómez, B. J. Johnson, H. C. Bossin and R. Argilés-Herrero,  Insects,  14. 2023.
The research carried out in the framework of this CRP generated key achievements in areas relevant to the SIT application to control mosquitoes. Among these outcomes, particular mentions must be given to the following: (1) Novel and efficient self-marking techniques were ...
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Wolbachia Promotes Its Own Uptake by Host Cells

L. B. Nevalainen, E. M. Layton and I. L. G. Newton,  Infection and Immunity,  e0055722. 2023.
Wolbachia pipientis is an incredibly widespread bacterial symbiont of insects, present in an estimated 25 to 52% of species worldwide. Wolbachia is faithfully maternally transmitted both in a laboratory setting and in the wild. In an established infection, Wolbachia is primarily ...
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Wolbachia RNase HI contributes to virus blocking in the mosquito Aedes aegypti

M. Hussain, G. Zhang, M. Leitner, L. M. Hedges and S. Asgari,  iScience,  26:105836. 2023.
The endosymbiotic bacterium Wolbachia pipientis blocks replication of several arboviruses in transinfected Aedes aegypti mosquitoes. However, the mechanism of virus blocking remains poorly understood. Here, we characterized an RNase HI gene from Wolbachia, which is rapidly ...
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Engineered symbiotic bacteria interfering <em>Nosema</em> redox system inhibit microsporidia parasitism in honeybees

H. Lang, H. Wang, H. Wang, X. Xie, X. Hu, X. Zhang and H. Zheng,  bioRxiv,  2023.01.13.524015. 2023.
Nosema ceranae is an emergent microsporidia parasite of the European honey bee (Apis mellifera), which causes serious nosemosis implicated in honeybee colony losses worldwide. N. ceranae is an obligate intracellular eukaryotic parasite that mainly invades the midgut of honeybees. ...
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Dynamics of an impulsive reaction-diffusion mosquitoes model with multiple control measures

Y. Li, H. Zhao and K. Wang,  Mathematical Biosciences and Engineering,  20:775-806. 2023.
It is well-known that mosquito control is one of the effective methods to reduce and prevent the transmission of mosquito-borne diseases. In this paper, we formulate a reaction-diffusion impulsive hybrid model incorporating Wolbachia, impulsively spraying of insecticides, spatial ...
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Bypassing Mendel’s First Law: Transmission Ratio Distortion in Mammals

G. Friocourt, A. Perrin, P. A. Saunders, E. Nikalayevich, C. Voisset, C. Coutton, G. Martinez and F. Morel,  International Journal Molecular Sciences,  24. 2023.
Mendel's law of segregation states that the two alleles at a diploid locus should be transmitted equally to the progeny. A genetic segregation distortion, also referred to as transmission ratio distortion (TRD), is a statistically significant deviation from this rule. TRD has ...
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Genetic conversion of a split-drive into a full-drive element

G. Terradas, J. B. Bennett, Z. Li, J. M. Marshall and E. Bier,  Nature Communications,  14:191. 2023.
The core components of CRISPR-based gene drives, Cas9 and guide RNA (gRNA), either can be linked within a self-contained single cassette (full gene-drive, fGD) or be provided in two separate elements (split gene-drive, sGD), the latter offering greater control options. We ...
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Single-cell transcriptome sequencing reveals Wolbachia-mediated modification in early stages of Drosophila spermatogenesis

W. Dou, B. Sun, Y. Miao, D. Huang and J. Xiao,  Proceedings of the Royal Society B: Biological Sciences,  290:20221963. 2023.
Wolbachia are the most widely distributed intracellular bacteria, and their most common effect on host phenotype is cytoplasmic incompatibility (CI). A variety of models have been proposed to decipher the molecular mechanism of CI, among which the host modification (HM) model ...
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Single-cell transcriptome sequencing reveals Wolbachia-mediated modification in early stages of Drosophila spermatogenesis

W. Dou, B. Sun, Y. Miao, D. Huang and J. Xiao,  Proceedings of the Royal Society B: Biological Sciences,  290:20221963. 2023.
Wolbachia are the most widely distributed intracellular bacteria, and their most common effect on host phenotype is cytoplasmic incompatibility (CI). A variety of models have been proposed to decipher the molecular mechanism of CI, among which the host modification (HM) model ...
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Heterogeneous distribution of sex ratio distorters in natural populations of the isopod Armadillidium vulgare

S. Durand, B. Lheraud, I. Giraud, N. Bech, F. Grandjean, T. Rigaud, J. Peccoud and R. Cordaux,  Biology Letters,  19:20220457. 2023.
In the isopod Armadillidium vulgare, many females produce progenies with female-biased sex ratios, owing to two feminizing sex ratio distorters (SRD): Wolbachia endosymbionts and the f element. We investigated the distribution and population dynamics of these SRD and ...
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Effects of gamma radiation on the vector competence of Aedes aegypti (diptera: Culicidae) to transmit Zika virus

E. B. da Silva, C. M. de Mendonça, D. R. D. Guedes, M. H. S. Paiva, J. d. A. Mendonça, E. S. F. Dias, S. G. L. Florêncio, A. Amaral, A. M. Netto, C. F. J. A. Lopes and M. A. V. de Melo-Santos,  Acta Tropica,  239:106831. 2023.
One of the limitations of the Sterile Insect Technique (SIT), conventionally performed by ionizing radiation, regards separating males from females, which is not 100% effective. Some irradiated females may be released together with males in the field at SIT. The present study ...
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Trust in science and scientists: Effects of social attitudes and motivations on views regarding climate change, vaccines and gene drive technology

H. G. W. Dixson, A. F. Komugabe-Dixson, F. Medvecky, J. Balanovic, H. Thygesen and E. A. MacDonald,  Journal of Trust Research,  2023.
Trust in science and scientists (TSS) is an increasingly important topic with respect to how science is applied within society. However, its role regarding specific issues may vary depending upon other psychosocial factors. In this study, we investigated how trust interacts with ...
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