Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression

M. E. Williamson, Y. Yan and M. J. Scott,  PLOS Genetics,  17:e1009792. 2021.

In the fruit fly Drosophila melanogaster and in the mosquito Anopheles gambiae, a single gene (Sxl in D. melanogaster, fle in A. gambiae) controls the development of female-specific tissues and X chromosome dosage compensation, which is the equalization of X-linked gene products in males and females. In this study we find evidence that the transformer gene is essential for somatic sex differentiation and repression of X chromosome dosage compensation in female sheep blow fly, Lucilia cuprina. In several of the transgenic strains developed, females are transformed into males on diet that lacks tetracycline. Consequently, these strains could be part of a genetic control program of this major pest of sheep in Australia.

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