Gene Drives Work in Mice (if They’re Female)

Rennie, JC, Jordana,  Quanta Magazine,  2019.

Conservationists and bioethicists often regard the packages of engineered DNA called “gene drives” with a mixture of wonder, excitement and dread. Gene drives violate the normal rules of inheritance by making sure they get passed down to all of their host organism’s offspring, not just to half of them; they therefore have the unnerving potential to rapidly and irrevocably alter a population. Much of the controversy about gene drives has centered on the practicality (and hubris) of using them to control dangerous insect pests, since insects were about the only animals in which gene drives had been shown to work.