Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast: excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd Locus is the key distorting gene responsible for this phenotype. A genomic fragment from the Sd region conferred full distorting activity when introduced into the appropriate genetic background by germline transformation. The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product.
https://www.geneconvenevi.org/wp-content/uploads/2020/04/Science-11.png300300Academic Web Pages/wp-content/uploads/2019/10/GC-color-logo-for-header-3277-x-827-1030x260.pngAcademic Web Pages1999-01-17 00:00:002020-04-22 16:45:52Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila