Unravelling transmission ratio distortion across the bovine genome: identification of candidate regions for reproduction defects

S. Id-Lahoucine, J. Casellas, A. Suárez-Vega, P. A. S. Fonseca, F. S. Schenkel, M. Sargolzaei and A. Cánovas,  BMC Genomics,  24:383. 2023.

Biological mechanisms affecting gametogenesis, embryo development and postnatal viability have the potential to alter Mendelian inheritance expectations resulting in observable transmission ratio distortion (TRD). Although the discovery of TRD cases have been around for a long time, the current widespread and growing use of DNA technologies in the livestock industry provides a valuable resource of large genomic data with parent–offspring genotyped trios, enabling the implementation of TRD approach. In this research, the objective is to investigate TRD using SNP-by-SNP and sliding windows approaches on 441,802 genotyped Holstein cattle and 132,991 (or 47,910 phased) autosomal SNPs. Our results revealed the importance of implementing different TRD parameterizations to capture all types of distortions and to determine the corresponding inheritance pattern. Novel candidate genomic regions containing lethal alleles and genes with functional and biological consequences on fertility and pre‑ and post‑natal viability were also identified, providing opportunities for improving breeding success in cattle

More related to this: