X chromosome effect on maternal recombination and meiotic drive in the mouse

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X chromosome effect on maternal recombination and meiotic drive in the mouse

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de la Casa-Esperon, EL-O, J. C.; de Villena, F. P. M.; Briscoe, T. L.; Malette, J. M.; Vaughan, J. E.; Morgan, K.; Sapienza, C.,  Genetics,  161:1651-1659. 2002.

We observed that maternal meiotic drive favoring the inheritance of DDK alleles at the Om locus on mouse chromosome 11 was correlated with the X chromosome inactivation phenotype of (C57BL/6Pgk1(a) X DDK)F-1 mothers. The basis for this unexpected observation appears to lie in the well-documented effect of recombination on meiotic drive that results from nonrandom segregation of chromosomes. Our analysis of genome-wide levels of meiotic recombination in females that vary in their X-inactivation phenotype indicates that an allelic difference at an X-linked locus is responsible for modulating levels of recombination in oocytes.