Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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A sex-ratio meiotic drive system in Drosophila simulans. II: An X-linked distorter

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Tao, YA, L.; Kingan, S. B.; Ke, Y.; Xiao, H.; Hartl, D. L.,  PLOS Biology,  5:2576-2588. 2007.
The evolution of heteromorphic sex chromosomes creates a genetic condition favoring the invasion of sex-ratio meiotic drive elements, resulting in the biased transmission of one sex chromosome over the other, in violation of Mendel's first law. The molecular mechanisms of ...

Neurospora spore killers Sk-2 and Sk-3 suppress meiotic silencing by unpaired DNA

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Raju, NBM, R. L.; Shiu, P. T.,  Genetics,  176:43-52. 2007.
In Neurosphora, crassa., pairing of homologous DNA segments is monitored during meiotic prophase I. Any genes not paired with a homolog, as well as any paired homologs of that gene, are silenced during the sexual phase by a mechanism known as meiotic silencing by unpaired DNA ...

Meiotic drive by the Y-linked D gene in Aedes aegypti (L.) (Diptera : Culicidae) is associated with disruption of spermiogenesis, leading to premature senescence of spermatozoa

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Owusu-Daaku, KOB, R. D.; Wood, R. J.,  Arthropod Structure & Development,  36:233-243. 2007.
Y chromosome meiotic drive in the mosquito Aedes aegypti, due to the gene D (Distorter) in coupling with M (male determination) [the MD haplotype], is associated with spermiogenic disruption, leading to senescence, at a rate Proportionate to male excess. Spermiogenesis was ...

Identification and characterization of segregation distortion loci along chromosome 5B in tetraploid wheat

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Kumar, SG, B. S.; Faris, J. D.,  Molecular Genetics and Genomics,  278:187-196. 2007.
Segregation distortion genes are widespread in plants and animals and function by their effect on competition among gametes for preferential fertilization. In this study, we evaluated the segregation distortion of molecular markers in multiple reciprocal backcross populations ...

Introducing desirable transgenes into insect populations using Y-linked meiotic drive – A theoretical assessment

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Huang, YXM, K.; Lloyd, A. L.; Gould, F.,  Evolution,  61:717-726. 2007.
The use of genetic drive mechanisms to replace native mosquito genotypes with individuals bearing antipathogen transgenes is a potential strategy for repressing insect transmission of human diseases such as malaria and dengue. Antipathogen transgenes have been developed and ...

Introducing transgenes into insect populations using combined gene-drive strategies: Modeling and analysis

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Huang, YXM, K.; Lloyd, A. L.; Gould, F.,  Insect Biochemistry and Molecular Biology,  37:1054-1063. 2007.
Engineered underdominance (EU), meiotic drive (MD) and Wolbachia have been proposed as mechanisms for driving anti-pathogen transgenes into natural populations of insect vectors of human diseases. EU can drive transgenes to high and stable frequencies but requires the release of ...

Chromosome-wide linkage disequilibrium as a consequence of meiotic drive

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Dyer, KAC, B.; Jaenike, J.,  Proceedings of the National Academy of Sciences of the United States of America,  104:1587-1592. 2007.
Adaptation by natural selection proceeds most efficiently when alleles compete solely on the basis of their effects on the survival and reproduction of their carriers. A major condition for this is equal Mendelian segregation, but meiotic drive can short-circuit this process. The ...

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila

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Chen, CHH, H. X.; Ward, C. M.; Su, J. T.; Schaeffer, L. V.; Guo, M.; Hay, B. A.,  Science,  316:597-600. 2007.
One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements ...

First Anopheles arabiensis germline transformation: Toward the development of a transgenic genetic sexing strain

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H. C. Bossin, J. Thailayil, F. Catteruccia, J. P. Benton, A. Crisanti, M. Q. Benedict, B. G. Knols and A. S. Robinson,  American Journal of Tropical Medicine and Hygiene,  75:66-66. 2006.
The ability to genetically engineer mosquitoes is likely to have major implications for the development and implementation of genetic control systems against mosquito disease vectors such as the Sterile Insect Technique (SIT). In particular, genetically transformed mosquito ...

The Sterile Insect Technique: can established technology beat malaria?

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M. E. H. Helinski, B. El-Sayed and B. G. J. Knols,  Entomologische Berichten,  66:13-20. 2006.
The Sterile Insect Technique (SIT) is the mass production, sterilisation and subsequent release of sterile insects into a target population in an area-wide integrated approach. The released sterile males mate with wild females; they thus no longer produce offspring and therefore ...

Radiation-induced sterility for pupal and adult stages of the malaria mosquito Anopheles arabiensis

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M. E. H. Helinski, A. G. Parker and B. G. J. Knols,  Malaria Journal,  5:10. 2006.
The optimal dose for male insects to be released in an SIT programme depends on their level of sterility and competitiveness. The use of semi-sterilizing doses to produce more competitive insects is discussed. The most convenient developmental stage for mosquito irradiation on a ...

Genetic strategies for controlling mosquito-borne diseases

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F. Gould, K. Magori and Y. Huang,  American Scientist,  94:238. 2006.
Malaria kills more than a million people each year, primarily children under the age of six. Dengue fever is less deadly, but an outbreak can debilitate millions of people and easily overwhelm doctors and hospitals in tropical cities

The hitchhiking effect of an autosomal meiotic drive gene

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Chevin, LMH, F.,  Genetics,  173:1829-1832. 2006.
Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact ...

Cage trials using an endogenous meiotic drive gene in the mosquito Aedes aegypti to promote population replacement

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Cha, SJM, A.; Chadee, D. D.; Severson, D. W.,  American Journal of Tropical Medicine and Hygiene,  74:62-68. 2006.
Control of arthropod-borne diseases based on population replacement with genetically modified noncompetent vectors has been proposed as a promising alternative to conventional control strategies. Due to likely fitness costs associated with vectors manipulated to carry ...

Isolation and characterization of the RanGAP gene in the mosquito Aedes aegypti

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Cha, SJL, N.; Debruyn, B.; Severson, D. W.,  DNA Sequence,  17:223-230. 2006.
A duplicated 3'-truncated version of RanGAP was previously identified as Segregation distorter (Sd), the meiotic drive gene in Drosophila melanogaster. Here we report the cloning and characterization of the complete gene sequence for the RanGAP homolog from the mosquito Aedes ...

Population dynamics of an endogenous meiotic drive system in Aedes aegypti in Trinidad

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Cha, SJC, D. D.; Severson, D. W.,  American Journal of Tropical Medicine and Hygiene,  75:70-77. 2006.
An endogenous meiotic drive system was previously reported to be segregating in the yellow fever mosquito Aedes aegypti L. (Diptera: Culicidae) population in Trinidad. The meiotic driver (M-D) is tightly linked to the male determining locus and selectively targets sensitive ...

Fitness effects of X chromosome drive in the stalk-eyed fly, Cyrtodiopsis dalmanni

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Wilkinson, GSJ, P. M.; Kelleher, E. S.; Muscedere, M. L.; Lorsong, A.,  Journal of Evolutionary Biology,  19:1851-1860. 2006.
Sex-ratio (SR) males produce predominantly female progeny because most Y chromosome sperm are rendered nonfunctional. The resulting transmission advantage of X-SR chromosomes should eventually cause population extinction unless segregation distortion is masked by suppressors or ...

Segregation distortion in Arabidopsis C24/Col-0 and Col-0/C24 recombinant inbred line populations is due to reduced fertility caused by epistatic interaction of two loci

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Torjek, OW-W, H.; Meyer, R. C.; von Korff, M.; Kusterer, B.; Rautengarten, C.; Altmann, T.,  Theoretical and Applied Genetics,  113:1551-1561. 2006.
A new large set of reciprocal recombinant inbred lines (RILs) was created between the Arabidopsis accessions Col-0 and C24 for quantitative trait mapping approaches, consisting of 209 Col-0 x C24 and 214 C24 x Col-0 F-7 RI lines. Genotyping was performed using 110 evenly ...

Gene drive systems for insect disease vectors

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Sinkins, SPG, F.,  Nature Reviews Genetics,  7:427-435. 2006.
The elegant mechanisms by which naturally occurring selfish genetic elements, such as transposable elements, meiotic drive genes, homing endonuclease genes and Wolbachia, spread at the expense of their hosts provide some of the most fascinating and remarkable subjects in ...

A model describing the effect of sex-reversed YY fish in an established wild population: The use of a Trojan Y chromosome to cause extinction of an introduced exotic species

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J. B. Gutierrez and J. L. Teem,  Journal of Theoretical Biology,  241:333-341. 2006.
A novel means of inducing extinction of an exotic fish population is proposed using a genetic approach to shift the ratio of male to females within a population. In the proposed strategy, sex-reversed fish containing two Y chromosomes are introduced into a normal fish population. ...

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