Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Evolution of segregation distortion: Potential for a high degree of polymorphism

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van Boven, MW, F. J.,  Journal of Theoretical Biology,  192:131-142. 1998.
By means of a population genetical model, we study the evolution of segregation distortion. Most models of segregation distortion focus on a single distorter allele. In contrast, we consider the competition between a large number of distorters. Motivated by systems as the t ...

The dynamics of maternal-effect selfish genetic elements

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Smith, NGC,  Journal of Theoretical Biology,  191:173-180. 1998.
Maternal-effect selfish genes such as Medea or Seat act to kill progeny that do not bear a copy of the selfish gene present in the mother. Previous models of this system allowed for two types of allele, the selfish (killer) type and the sensitive (susceptible) wild-type. These ...

Male sterility and meiotic drive associated with sex chromosome rearrangements in Drosophila: Role of X-Y pairing

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McKee, BDW, K.; Merrill, C.; Ren, X. J.,  Genetics,  149:143-155. 1998.
In Drosophila melanogaster, deletions of the pericentromeric X heterochromatin cause X-Y nondisjunction, reduced male fertility and distorted sperm recovery ratios (meiotic drive) in combination with a normal Y chromosome and interact with Y-autosome translocations (T(Y;A)) to ...

Segregation distortion in myotonic dystrophy

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Magee, ACH, A. E.,  Journal of Medical Genetics,  35:1045-1046. 1998.
Myotonic dystrophy (DM) is an autosomal dominant disease which, in the typical pedigree, shows a three generation anticipation cascade. This results in infertility and congenital myotonic dystrophy (CDM) with the disappearance of DM in that pedigree. The concept of segregation ...

Sex ratio distortion in Acraea encedon (Lepidoptera : Nymphalidae) is caused by a male-killing bacterium

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Jiggins, FMH, G. D. D.; Majerus, M. E. N.,  Heredity,  81:87-91. 1998.
Females of the butterfly Acraea encedon produce either entirely female offspring or males and females in an almost 1:1 sex ratio. The sex ratio produced is maternally inherited and was previously attributed to sex chromosome meiotic drive. We report that all-female lineages are ...

Selfish genes and meiotic drive

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Hurst, LD,  Nature,  391:223-223. 1998.
Work by Gerald Wilkinson and colleagues3 on stalk-eyed flies (Diopsidae), described on page 276, provides the strongest evidence to date about the nature of some of the genes females prefer. As their name suggests, stalk-eyed flies have their eyes perched on the end of ...

Selfish genetic elements and speciation

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Hurst, GDDS, M.,  Heredity,  80:2-8. 1998.
This review concerns the importance of selfish genetic elements (SGEs) in speciation. We assess the importance of medea genes, meiotic drive elements, transposable elements and the bacterium Wolbachia in the creation of postzygotic isolation. Although all of these elements can ...

Identification of the t complex-encoded cytoplasmic dynein light chain Tctex1 in inner arm I1 supports the involvement of flagellar dyneins in meiotic drive

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Harrison, AO-C, P.; King, S. M.,  Journal of Cell Biology,  140:1137-1147. 1998.
The cytoplasmic dynein light chain Tctex1 is a candidate for one of the distorter products involved in the non-Mendelian transmission of mouse t haplotypes. It has been unclear, however, how the t-specific mutations in this protein, which is found associated with cytoplasmic ...

Malaria: existing methods of vector control and molecular entomology

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Curtis, CFT, H.,  British Medical Bulletin,  54:311-325. 1998.
In general, the most effective means of malaria vector control is the killing of adult mosquitoes with a residual insecticide applied to bednets or sprayed on house walls and ceilings. Major reductions in all-cause child mortality have been achieved in Africa by these means. In ...

Wolbachia as a possible means of driving genes into populations

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Curtis, CFS, S. P.,  Parasitology,  116:S111-S115. 1998.
Cytoplasmic incompatibility consists of sterility in cross matings, the crossing type being maternally inherited. It can be explained by the action of Wolbachia symbionts which are transmitted through the egg cytoplasm and leave an imprint on the sperm which prevents it ...

Localization of the genes controlling B chromosome transmission rate in maize (Zea mays ssp. mays, Poaceae)

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Chiavarino, AMR, M.; Rosi, P.; Poggio, L.; Naranjo, C. A.,  American Journal of Botany,  85:1581-1585. 1998.
In previous papers we found that the frequency of B chromosomes in native races of maize varies considerably in different populations. Moreover, we found genotypes that control high and low transmission rates (TR) of B chromosomes in the Pisingallo race. In the present work ...

Selfish DNA and breeding system in flowering plants

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Burt, AT, R.,  Proceedings of the Royal Society B-Biological Sciences,  265:141-146. 1998.
In many species, some individuals carry one or more B chromosomes: extra, or supernumerary chromosomes not part of the normal complement. In most well-studied cases, B's lower the fitness of their carrier and persist in populations only because of accumulation mechanisms ...

Putting the brake on drive: meiotic drive of t haplotypes in natural populations of mice

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Ardlie, KG,  Trends in Genetics,  14:189-193. 1998.
Mouse t haplotypes are a 'selfish' form of chromosome 17 that show non-mendelian transmission from heterozygous +/t males. The considerable transmission bias in favour of t haplotypes should result in very high frequencies of these chromosomes in natural populations, but they ...

Polymorphism for Y-linked suppressors of sex-ratio in two natural populations of Drosophila mediopunctata

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Carvalho, ABV, S. C.; Klaczko, L. B.,  Genetics,  146:891-902. 1997.
In several Drosophila species there is a trait known as ''sex-ratio'': males carrying certain X chromosomes (called ''SR'') produce female biased progenies due to X-Y meiotic drive. In Drosophila mediopunctata this trait has a variable expression due to Y-linked suppressors of ...

Identification of a male meiosis-specific gene, Tcte2, which is differentially spliced in species that form sterile hybrids with laboratory mice and deleted in t chromosomes showing meiotic drive

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Braidotti, GB, D. P.,  Developmental Biology,  186:85-99. 1997.
Tcte2 (t complex testes expressed 2) is a male meiosis-specific gene that maps to band 3.3 of mouse chromosome 17. Two distinct male fertility defects, hybrid sterility and transmission ratio distortion, have previously been mapped to this region. Hybrid sterility arises in ...

The sex-ratio trait in Drosophila simulans: Geographical distribution of distortion and resistance

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Atlan, AM, H.; Landre, C.; Montchamp-Moreau, C.,  Evolution,  51:1886-1895. 1997.
The sex-ratio trait we describe here in Drosophila simulans results from X-linked meiotic drive. Males bearing a driving X chromosome can produce a large excess of females (about 90%) in their progeny. This is, however, rarely the case in the wild, where resistance factors, ...

Non-Mendelian transmission at the Machado-Joseph disease locus in normal females: Preferential transmission of alleles with smaller CAG repeats

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Rubinsztein, DCL, J.,  Journal of Medical Genetics,  34:234-236. 1997.
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a neurodegenerative disorder which is associated with a CAG repeat expansion in the MJD1 gene on chromosome 14q32.1. A recent study reported an excess of transmission of disease chromosomes relative to ...

Sex chromosome meiotic drive in stalk-eyed flies

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Presgraves, DCS, E.; Wilkinson, G. S.,  Genetics,  147:1169-1180. 1997.
Meiotically driven sex chromosomes can quickly spread to fixation and cause population extinction unless balanced by selection or suppressed by genetic modifiers. We report results of genetic analyses that demonstrate that extreme female-biased sex ratios in two sister species of ...

Variation in Y chromosome meiotic drive in Aedes aegypti (Diptera: Culicidae): a potential genetic approach to mosquito control

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OwusuDaaku, KOW, R. J.; Butler, R. D.,  Bulletin of Entomological Research,  87:617-623. 1997.
Reciprocal crosses between strains of Aedes aegypti (Linnaeus) from different geographical areas have revealed an unexpectedly complex pattern of holandrically inherited male biased sex ratios in F2. The variation has been interpreted in terms of a web of X-Y interactions in F1, ...

Selected lines of Aedes aegypti with persistently distorted sex ratios

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OwusuDaaku, KOW, R. J.; Butler, R. D.,  Heredity,  79:388-393. 1997.
A breeding scheme to isolate X chromosomes sensitive to drive by the T8 (Trinidad) Y chromosome of Aedes aegypti (the MD haplotype) is reported. Crosses with an Australian strain Th.I (Thursday Island) revealed not only sensitive and resistant X chromosomes but also some with the ...

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