Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Defects in nuclear transport enhance segregation distortion

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McElroy, JMM, R. A.; McLean, J. R.,  Fly,  2:280-290. 2008.
The equal segregation of chromosomes into gametes is a central tenet of Mendelian genetics. It is this process that is responsible for generating predictable outcomes of crosses, as well as subjecting all chromosomes to the natural selective pressures that exert themselves on a ...

Transmission ratio distortion in Arabidopsis lyrata: effects of population divergence and the S-locus

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Leppala, JB, J. S.; Schierup, M. H.; Savolainen, O.,  Heredity,  100:71-78. 2008.
We investigated transmission ratio distortion within an Icelandic population of Arabidopsis lyrata using 16 molecular markers unlinked to the S-locus. Transmission ratio distortion was found more often than expected by chance at the gametic level, but not at the genotypic or ...

The evolution of sex-independent transmission ratio distortion involving multiple allelic interactions at a single locus in rice

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Koide, YI, M.; Sawamura, N.; Nishimoto, D.; Matsubara, K.; Onishi, K.; Kanazawa, A.; Sano, Y.,  Genetics,  180:409-420. 2008.
Transmission ratio distortion (TRD) is frequently observed in inter-and intraspecific hybrids of plants, leading to a violation of Mendelian inheritance. Sex-independent TRD (siTRD) was detected in a hybrid between Asian cultivated rice and its wild ancestor. Here we examined how ...

X chromosome drive

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Jaenike, J,  Current Biology,  18:R508-R511. 2008.
In the past 10 years, the world record for the men's 100 meter dash has declined from 9.79 to 9.74 seconds, the detection of such small differences being made possible by sophisticated electronic timing devices. If someone were to run the 100 meters in 9.73999 seconds in the 2008 ...

A Killer–Rescue system for self-limiting gene drive of anti-pathogen constructs

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Gould, FH, Yunxin; Legros, Mathieu; Lloyd, Alun L.,  Proceedings of the Royal Society B: Biological Sciences,  275:2823-2829. 2008.
A number of genetic mechanisms have been suggested for driving anti-pathogen genes into natural populations. Each of these mechanisms requires complex genetic engineering, and most are theoretically expected to permanently spread throughout the target species' geographical range. ...

Broadening the application of evolutionarily based genetic pest management

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Gould, F,  Evolution,  62:500-510. 2008.
Insect- and tick-vectored diseases such as malaria, dengue fever, and Lyme disease cause human suffering, and current approaches for prevention are not adequate. Invasive plants and animals such as Scotch broom, zebra mussels, and gypsy moths continue to cause environmental ...

Centromere-associated female meiotic drive entails male fitness costs in Monkeyflowers

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Fishman, LS, A.,  Science,  322:1559-1562. 2008.
Female meiotic drive, in which paired chromosomes compete for access to the egg, is a potentially powerful but rarely documented evolutionary force. In interspecific monkeyflower ( Mimulus) hybrids, a driving M. guttatus allele ( D) exhibits a 98: 2 transmission advantage via ...

Selective sweeps in a 2-locus model for sex-ratio meiotic drive in Drosophila simulans

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Derome, NB, E.; Ogereau, D.; Veuille, M.; Montchamp-Moreau, C.,  Molecular Biology and Evolution,  25:409-416. 2008.
A way to identify loci subject to positive selection is to detect the signature of selective sweeps in given chromosomal regions. It is revealed by the departure of DNA polymorphism patterns from the neutral equilibrium predicted by coalescent theory. We surveyed DNA sequence ...

The population genetics of using homing endonuclease genes in vector and pest management

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Deredec, AB, A.; Godfray, H. C. J.,  Genetics,  179:2013-2026. 2008.
Homing endonuclease genes (HEGs) encode proteins that in the heterozygous state cause double- strand breaks in the homologous chromosome at the precise position opposite the HFG. If the double-strand break is repaired using the homologous chromosome, the HEG becomes homozygous, ...

Rapid evolution of yeast centromeres in the absence of drive

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Bensasson, DZ, M.; Burt, A.; Koufopanou, V.,  Genetics,  178:2161-2167. 2008.
To find the most rapidly evolving regions in the yeast genome we compared most of chromosome III from three closely related lineages of the wild yeast Saccharomyces paradoxits. Unexpectedly, the centromere appears to be the fastest-evolving part of the chromosome, evolving even ...

Guidance for contained field trials of vector mosquitoes engineered to contain a gene drive system: Recommendations of a scientific working group

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Benedict, MDA, P.; Dobson, S.; Gottlieb, M.; Harrington, L.; Higgs, S.; James, A.; James, S.; Knols, B.; Lavery, J.; O'Neill, S.; Scott, T.; Takken, W.; Toure, Y.; Core Working Grp Guidance, Containe,  Vector-Borne and Zoonotic Diseases,  8:127-166. 2008.
The following recommendations represent the response of a group of involved scientists to the need for guidance to aid researchers, government authorities, and community leaders as they consider the design and implementation of field trials to assess the safety and efficacy of ...

Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae

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Windbichler, NP, P. A.; Crisanti, A.,  PLOS Genetics,  4:1-9. 2008.
We have exploited the high selectivity of the homing endonuclease I-PpoI for the X-linked Anopheles gambiae 28S ribosomal genes to selectively target X chromosome carrying spermatozoa. Our data demonstrated that in heterozygous males, the expression of I-PpoI in the testes ...

Meiotic drive and sex determination: molecular and cytological mechanisms of sex ratio adjustment in birds

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Rutkowska, JB, A. V.,  Philosophical Transactions of the Royal Society B-Biological Sciences,  363:1675-1686. 2008.
Differences in relative fitness of male and female offspring across ecological and social environments should favour the evolution of sex-determining mechanisms that enable adjustment of brood sex ratio to the context of breeding. Despite the expectation that genetic sex ...

Sexually antagonistic “Zygotic Drive” of the sex Chromosomes

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Rice, WRG, S.; Friberg, U.,  PLOS Genetics,  4:e1000313. 2008.
Genomic conflict is perplexing because it causes the fitness of a species to decline rather than improve. Many diverse forms of genomic conflict have been identified, but this extant tally may be incomplete. Here, we show that the unusual characteristics of the sex chromosomes ...

Selfish genetic elements promote polyandry in a fly

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Price, TARH, D. J.; Lewis, Z.; Hurst, G. D. D.; Wedell, N.,  Science,  322:1241-1243. 2008.
It is unknown why females mate with multiple males when mating is frequently costly and a single copulation often provides enough sperm to fertilize all a female's eggs. One possibility is that remating increases the fitness of offspring, because fertilization success is biased ...

Control of introduced species using Trojan sex chromosomes

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S. Cotton and C. Wedekind,  Trends in Ecology & Evolution,  22:441-443. 2007.
To control introduced exotic species that have predominantly genetic, but environmentally reversible, sex determination (e.g. many species of fish), Gutierrez and Teem recently modeled the use of carriers of Trojan Y chromosomes - individuals who are phenotypically sex reversed ...

Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos

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Windbichler, NP, P. A.; Catteruccia, F.; Ranson, H.; Burt, A.; Crisanti, A.,  Nucleic Acids Research,  35:5922-5933. 2007.
Homing endonuclease genes (HEGs) are selfish genetic elements that combine the capability to selectively disrupt specific gene sequences with the ability to rapidly spread from a few individuals to an entire population through homologous recombination repair events. Because of ...

Viability effects and not meoitic drive cause dramatic departures from Mendelian inheritance for malic enzyme in hybrids of Tigriopus californicus populations

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Willett, CSB, J. N.,  Journal of Evolutionary Biology,  20:1196-1205. 2007.
The genetic basis of post-zygotic reproductive isolation is beginning to be untangled in closely related species, but less is known about the genetics of reproductive isolation between divergent populations. Here, two genes encoding malic enzyme (ME) are isolated from the copepod ...

Small steps or giant leaps for male-killers? Phylogenetic constraints to male-killer host shifts

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Tinsley, MCM, M. E. N.,  BMC Evolutionary Biology,  7:e1000313. 2007.
Background: Arthropods are infected by a wide diversity of maternally transmitted microbes. Some of these manipulate host reproduction to facilitate population invasion and persistence. Such parasites transmit vertically on an ecological timescale, but rare horizontal ...

A sex-ratio meiotic drive system in Drosophila simulans. I: An autosomal suppressor

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Tao, YM, J. P.; Araripe, L.; Ke, Y.; Hartl, D. L.,  PLOS Biology,  5:2560-2575. 2007.
Sex ratio distortion (sex-ratio for short) has been reported in numerous species such as Drosophila, where distortion can readily be detected in experimental crosses, but the molecular mechanisms remain elusive. Here we characterize an autosomal sex-ratio suppressor from D. ...

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