Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
Disclaimer>

Functional constraints of wtf killer meiotic drivers

Tags: ,
Nidamangala Srinivasa A, Campbell S, Venkatesan S, et al.,  PLOS Genetics,  21. 2025.
Killer meiotic drivers are selfish DNA loci that sabotage the gametes that do not inherit them from a driver+/driver− heterozygote. These drivers often employ toxic proteins that target essential cellular functions to cause the destruction of driver− gametes. Identifying the ...

Small RNA-mediated suppression of sex chromosome meiotic conflicts during Drosophila male gametogenesis

Tags: ,
Vedanayagam, J.,  Biochemical Society Transactions,  53:281-291. 2025.
Meiosis is an evolutionarily conserved process in eukaryotes that ensures equal segregation of alleles and chromosomes during reproduction. Although parity in allelic transmission is the norm, selfish genes such as meiotic drivers can violate Mendel’s first law of segregation. ...

Public attitudes to genetic technology for invasive pest control and preferences for engagement and information: a segmentation analysis

Tags: , ,
Hobman E.V., Mankad A., Carter, L., Collins K.,  Frontiers in Bioengineering and Biotechnology,  12. 2025.
Advances in genetic technology hold promise in managing the increasing problem of invasive pests. The current study sought to improve our understanding of public perceptions, and potential public engagement pathways and information needs as the technology is researched and ...

Suppression of Aedes aegypti may not affect sympatric Aedes albopictus populations: findings from two years of entomological surveillance in Singapore

Tags: , ,
Wong, W.J., Tan, C.H., Verkaik, M.G. et al.,  Scientific Reports,  15:2253. 2025.
Globally, multiple trials have successfully demonstrated the effectiveness of novel tools, such as the sterile and incompatible insect techniques, in suppressing Aedes aegypti populations. However, there is concern that Aedes albopictus, another arbovirus-competent vector, may ...

Controlling the frequency dynamics of homing gene drives for intermediate outcomes

Tags: , ,
Camm B., Fournier-Level A.,  G3: Genes|Genomes|Genetics,  2025.
Gene drives have enormous potential for solving biological issues by forcing the spread of desired alleles through populations. However, to safeguard from the potentially irreversible consequences on natural populations, gene drives with intermediate outcomes that neither fixate ...

Generating sterile Anopheles mosquitoes to combat malaria transmission

Tags: , , ,
Xu, X. and Champer, J.,  Research Communities by Springer Nature,  2025.
Malaria remains a deadly disease, claiming hundreds of thousands of lives worldwide every year. The primary vectors of malaria are Anopheles mosquitoes, including Anopheles gambiae and Anopheles stephensi. Controlling mosquito populations is crucial for stopping malaria ...

Establishment of pupal color as a screening marker and activity analysis of six U6 promoters in Zeugodacus cucurbitae using the white pupae gene

Tags: , ,
Fan Z., Wu Y., Zha X., Ma S., et al.,  Pest Management Science,  2025.
The genetic control method, which is environmentally friendly and species-specific, has effectively reduced or eliminated pests in many areas. One essential requirement to control a species is the identification of its genetic and molecular elements. Such elements, however, are ...

Upscaling irradiation protocols of Aedes albopictus pupae within an SIT program in Reunion Island

Tags: , , , ,
Lucie Marquereau, Hanano Yamada, David Damiens, Antonin Leclercq, Brice Derepas, Cécile Brengues , Brice William Dain , Quentin Lejarre 1, Mickael Proudhon , Jeremy Bouyer and Louis Clément Gouagna,  Scientific Reports,  14:12117. 2025.
The implementation of the sterile insect technique against Aedes albopictus relies on many parameters, in particular on the success of the sterilization of males to be released into the target area in overflooding numbers to mate with wild females. Achieving consistent sterility ...

Life-history traits of a fluorescent Anopheles arabiensis genetic sexing strain introgressed into South African genomic background

Tags: , , , ,
Nonhlanhla L. Ntoyi, Thabo Mashatola, Jérémy Bouyer, Carina Kraupa, Hamidou Maiga, Wadaka Mamai, Nanwintoum, Bimbile‑Somda, Thomas Wallner, Danilo O. Carvalho, Givemore Munhenga and Hanano Yamada,  Malaria Journal,  21. 2025.
South Africa has set a mandate to eliminate local malaria transmission by 2023. In pursuit of this objective a Sterile Insect Technique programme targeting the main vector Anopheles arabiensis is currently under development. Significant progress has been made towards ...

Animal trypanosomosis eliminated in a major livestock production region in Senegal following the eradication of a tsetse population

Tags: , , , , ,
Momar Talla Seck, Assane Guèye Fall, Adji Marème Gaye, Geoffrey Gimonneau, Mamadou Ciss, Mame Thierno Bakhoum, Baba Sall, Mireille Djimangali Bassène1, Renaud Lancelot, Marc J.B., Vreysen, and Jérémy Bouyer,  Parasite 31,  31. 2025.
African animal trypanosomosis (AAT) was one of the main disease-related constraints to the development of intensive livestock production systems in the Niayes region of Senegal, a 30 km wide strip of land along the coast between Dakar and Saint-Louis. To overcome this constraint, ...

Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication

Tags: , ,
Abraham, I.C., Aboje, J.E., Ukoaka, B.M. et al.,  Malaria Journal,  24. 2025.
Malaria remains a significant public health challenge, particularly in low- and middle-income countries, despite ongoing efforts to eradicate the disease. Recent advancements, including the rollout of malaria vaccines, such as RTS,S/AS01 and R21/Matrix-M™, offer new avenues for ...

Gene drive-based population suppression in the malaria vector Anopheles stephensi

Tags: , ,
Xu, X., Chen, J., Wang, Y. et al.,  Nature Communications,  16:1007. 2025.
Gene drives are alleles that can bias the inheritance of specific traits in target populations for the purpose of modification or suppression. Here, we construct a homing suppression drive in the major urban malaria vector Anopheles stephensi targeting the female-specific exon of ...

Assessing Radiation-Induced Enzyme Activation in Aedes aegypti: Potential Challenges for SIT-Based Vector Management

Tags: , ,
Edvane Borges da Silva, Sloana Giesta Lemos Florêncio, Ademir Amaral, et al.,  Acta Tropica,  261. 2025.
This study characterizes the Aedes aegypti population from Fernando de Noronha Island, Pernambuco, Brazil, prior to implementing the Sterile Insect Technique (SIT). The main objective was to assess changes in glutathione S-transferase (GST) enzyme activity, previously linked to ...

A comprehensive review of biological and genetic control approaches for leishmaniasis vector sand flies; emphasis towards promoting tools for integrated vector management

Tags: , ,
Kumari, Y., Gunathilaka, N., Amarasinghe, D.,  PLOS Neglected Tropical Diseases,  19. 2025.
Leishmaniasis is a health problem in many regions with poor health and poor life resources. According to the World Health Organization (WHO), an estimated 700,000–1 million new cases arise annually. Effective control of sand fly vector populations is crucial for reducing the ...

Assessment of drive efficiency and resistance allele formation of a homing gene drive in the mosquito Aedes aegypti

Tags: , , , ,
Yang, X., Xu, X., Chen, Y. et al.,  Journal of Pest Science,  2025.
Aedes aegypti, known for transmitting viruses such as dengue, Zika and yellow fever, poses a significant public health threat. Conventional insecticides give rise to a range of issues, including ecological contamination and insect resistance. Hence, there is a pressing demand for ...

Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana

Tags: , , ,
Ricou, A., Simon, M., Duflos, R., et al,  PLOS Genetics,  21. 2025.
Gamete killers are genetic loci that distort segregation in the progeny of hybrids because the killer allele promotes the elimination of the gametes that carry the sensitive allele. They are widely distributed in eukaryotes and are important for understanding genome evolution and ...

Escalation of genome defense capacity enables control of an expanding meiotic driver

Tags: , ,
P. Chen, K.C. Pan, E.H. Park, et al.,  Proceedings of the National Academy of Sciences,  122. 2025.
From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity. Despite their diversity, different defense pathways share a modular organization, where numerous specificity factors identify diverse ...

Wolbachia-Based Approaches to Controlling Mosquito-Borne Viral Threats: Innovations, AI Integration, and Future Directions in the Context of Climate Change

Tags: , , ,
Branda, F., Cella, E., Scarpa, F., et al.,  Viruses,  16:1868. 2025.
Wolbachia-based mosquito control strategies have gained significant attention as a sustainable approach to reduce the transmission of vector-borne diseases such as dengue, Zika, and chikungunya. These endosymbiotic bacteria can limit the ability of mosquitoes to transmit ...

Recommendations for Implementing Innovative Technologies to Control Aedes aegypti: Population Suppression Using a Combination of the Incompatible and Sterile Insect Techniques (IIT-SIT), Based on the Mexican Experience/Initiative

Tags: , , , ,
Martín-Park, A., Contreras-Perera, Y., et al.,  Insects,  15:987. 2025.
The future of Aedes aegypti control emphasizes the transition from traditional insecticides toward more sustainable and multisectoral integrated strategies, like using Wolbachia-carrying mosquitoes for population suppression or replacement. We reviewed the integration of the ...

Mechanisms, Machinery, and Dynamics of Chromosome Segregation in Zea mays

Tags: ,
Duffy, Marissa E., Michael Ngaw, Shayna E. Polsky, et al.,  Genes,  15. 2025.
Zea mays (maize) is both an agronomically important crop and a powerful genetic model system with an extensive molecular toolkit and genomic resources. With these tools, maize is an optimal system for cytogenetic study, particularly in the investigation of chromosome segregation. ...

« First ‹ Previous 1 2 10 11 12 13 14 22 112 118 Next › Last »