Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Wolbachia-based emerging strategies for control of vector-transmitted disease

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Diego Montenegro, Gerardo Cortés-Cortés, María Guadalupe Balbuena-Alonso, et al.,  Acta Tropica,  260. 2024.
Dengue fever is a mosquito-transmitted disease of great public health importance. Dengue lacks adequate vaccine protection and insecticide-based methods of mosquito control are proving increasingly ineffective. Here we review the emerging use of mosquitoes transinfected with the ...

The potential of gene drives in malaria vector species to control malaria in African environments

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Hancock, P.A., North, A., Leach, A.W. et al.,  Nature Communications,  15. 2024.
Gene drives are a promising means of malaria control with the potential to cause sustained reductions in transmission. In real environments, however, their impacts will depend on local ecological and epidemiological factors. We develop a data-driven model to investigate the ...

Practical Application of a Relationship-Based Model to Engagement for Gene-Drive Vector Control Programs

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Ana Kormos, Lodney Nazaré, Adionilde Aguiar dos Santos, and Gregory C. Lanzaro,  The American Journal of Tropical Medicine and Hygiene,  111:341-360. 2024.
Engagement is an important component in the advancement of gene-drive vector control research programs as developers look to transition the technology from the laboratory to the field. As research advances and engagement surrounding this novel technology is put into practice, ...

Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana

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Anthony Ricou, Matthieu Simon, et al.,  bioRxiv,  2024.
Certain genetic elements are qualified as selfish because they favor their transmission to the progeny during reproduction to the detriment of gametes that do not carry them. These elements are widespread in fungi as well as in plants or in animals, and they are made up of two or ...

Evolutionary modes of wtf meiotic driver genes in Schizosaccharomyces pombe

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Yan-Hui Xu, Fang Suo, Xiao-Ran Zhang, et al.,  Genome Biology and Evolution,  2024.
Killer meiotic drivers (KMDs) are a class of selfish genetic elements that bias inheritance in their favor by destroying meiotic progeny that do not carry them. How KMDs evolve is not well understood. In the fission yeast Schizosaccharomyces pombe, the largest gene family, known ...

Fluorescent-based sex-separation technique in major invasive crop pest, Drosophila suzukii

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Junru Liu, Danny Rayes, Minzhe Yang, Omar S. Akbari,  bioRxiv,  2024.
Insect population biocontrol methods such as the sterile insect technique (SIT), represent promising alternatives to traditional pesticide-based control applications. To use these strategies efficiently requires scalable sex separation techniques which are currently lacking in ...

Evaluation of Wolbachia infection in Aedes aegypti suggests low prevalence and highly heterogeneous distribution in Medellín, Colombia

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rley Calle-Tobón, Raúl Rojo-Ospina, et al.,  Acta Tropica,  260. 2024.
Dengue virus, transmitted mainly by Aedes aegypti mosquitoes, is a significant public health challenge in tropical and subtropical countries, with an incidence that is growing at an alarming rate. The release of Wolbachia-carrying mosquitoes has been suggested as a strategy to ...

Loss-of-function in testis-specific serine/threonine protein kinase triggers male infertility in an invasive moth

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Wei, Z., Wang, Y., Zheng, K. et al.,  Communications Biology,  7. 2024.
Genetic biocontrol technologies present promising and eco-friendly strategies for the management of pest and insect-transmitted diseases. Although considerable advancements achieve in gene drive applications targeting mosquitoes, endeavors to combat agricultural pests have been ...

Gene Drive and Symbiont Technologies for Control of Mosquito-Borne Diseases

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Guan-Hong Wang, Ary Hoffmann, and Jackson Champer,  Annual Review of Entomology,  70. 2024.
Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global health. Current control strategies with insecticides are only moderately effective. Scalable solutions are needed to reduce the transmission risk of these diseases. Symbionts and genome ...

Assessment of drive efficiency and resistance allele formation of a homing gene drive in the mosquito Aedes aegypti

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Xiaozhen Yang, Xuejiao Xu, et al.,  bioRxiv,  2024.
Aedes aegypti, known for transmitting viruses such as dengue, zika, and yellow fever, poses a significant public health threat. Conventional insecticides give rise to a range of issues, including ecological contamination and insect resistance. Hence, there is a pressing demand ...

Wolbachia infection in Aedes aegypti does not affect its vectorial capacity for Dirofilaria immitis

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Shirozu, T., Regilme, M.A.F., Ote, M. et al.,  Scientific Reports,  14. 2024.
Mosquito-borne diseases such as dengue and filariasis are a growing public health concern in endemic countries. Biological approaches, such as the trans-infection of Wolbachia pipientis in mosquitoes, are an alternative vector control strategy, especially for arthropod-borne ...

Stable introduction of Wolbachia wPip into invasive Anopheles stephensi for potential malaria control

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Yongkang Liang, Julian Liu, et al.,  PLoS Neglected Tropical Diseases,  2024.
Recent efforts have successfully utilized the endosymbiotic bacterium Wolbachia to control mosquito-transmitted viral diseases like dengue in multiple countries. However, similar initiatives have been limited in combating malaria, the most devastating and deadly mosquito-borne ...

Current status of the sterile insect technique for the suppression of mosquito populations on a global scale

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Bouyer, J.,  Infectious Diseases of Poverty,  13. 2024.
The World Health Organization (WHO) has emphasized the urgent need for alternative strategies to chemical insecticides for controlling mosquito populations, particularly the invasive Aedes species, which are known vectors of arboviruses. Among these alternative approaches, the ...

Communicating the uncertainties associated with genetic biocontrol approaches: insights from communicators, science journalists and scientists in Africa

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Tonui, W. K., Ogoyi, D., Thuo, C., Tareh, C., et al.,  Journal of Science Communication,  23. 2024.
Genetic biocontrol approaches, such as gene drive technology is rapidly gaining interest from scientists and public health professionals due to their potential to overcome many challenges of current malaria control tools and strategies. This is particularly the case in Africa ...

To CRISPR or Not to CRISPR? Ethical Considerations in Gene-Editing Insects

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Brendan Parent, Meghan Barrett,  American Entomologist,  70:54-57. 2024.
Genetically modified corn has helped feed the world (Hernandes-Lopes et al. 2023). Genetically modified mosquitoes could help eliminate devastating diseases like malaria (Hammond and Galizi 2017). Plainly, gene editing can serve some important human interests. Still, many people ...

B chromosome and its non-Mendelian inheritance in Atractylodes lancea

Hara K, Kikuchi S, Inoue M, Tsusaka T, Sakurai M, Tanabe H, et al.,  PLoS One,  2024.
Supernumerary B chromosomes contribute to intraspecific karyotypic variation. B chromosomes have been detected in more than 2000 organisms; they possess unique and diverse features, including non-Mendelian inheritance. Here, we report one or more B chromosomes in the ...

Viral gene drive spread during herpes simplex virus 1 infection in mice

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Walter, M., Haick, A.K., Riley, R. et al.,  Nature Communications,  15. 2024.
Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely on homologous recombination during sexual reproduction in diploid organisms such as insects, but we recently developed a gene drive in herpesviruses that relies on ...

Overcoming drug-resistant tumors with selection gene drives

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Hui Wang, Mingqi Xie,  Cell Genomics,  4. 2024.
Drug resistance is a major hurdle prohibiting effective treatment of many diseases, including cancer. Using model-guided designs, Leighow et al.1 engineered a dual-switch selection gene drive system custom designed to combat drug-resistant tumors. By demonstrating remarkable ...

Applications of Mathematical Programming to Genetic Biocontrol

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Váleri N. Vásquez, John M. Marshall,  SIAM Journal on Applied Mathematics,  84. 2024.
We review existing approaches to optimizing the deployment of genetic biocontrol technologies—tools used to prevent vector-borne diseases such as malaria and dengue—and formulate a mathematical program that enables the incorporation of crucial ecological and logistical ...

Mark–Release–Recapture Trial with Aedes albopictus (Diptera, Culicidae) Irradiated Males: Population Parameters and Climatic Factors

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Amaro FIF, Soares P, Velo E, et al,  Insects,  15. 2024.
Aedes albopictus mosquitoes spread arboviruses like dengue, Zika, or chikungunya. The Sterile Insect Technique (SIT) can be used as a prevention and control tool against Ae. albopictus populations. Mark–release–recapture (MRR) trials are fundamental to estimate the size of ...

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