Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae

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Tolosana, I., Willis, K., Gribble, M. et al.,  Nature Communications,  16:206. 2025.
Genetic control – the deliberate introduction of genetic traits to control a pest or vector population – offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of ...

Wolbachia-based mosquito control: Environmental perspectives on population suppression and replacement strategies

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Joydeb Bhattacharyya, Daniel L. Roelke,  Acta Tropica,  262. 2025.
Mosquito-borne diseases pose a significant threat to global health, and traditional mosquito control methods often fall short of effectiveness. A promising alternative is the biological control strategy of transinfecting mosquitoes with Wolbachia, a bacterium capable of ...

Meiotic Drive and Speciation

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Jeremy B. Searle and Fernando Pardo-Manuel de Villena,  Annual Review of Genetics,  58:341-363. 2024.
Meiotic drive is the biased transmission of alleles from heterozygotes, contrary to Mendel's laws, and reflects intragenomic conflict rather than organism-level Darwinian selection. Theory has been developed as to how centromeric properties can promote female meiotic drive and ...

Public attitudes to genetic technology for invasive pest control and preferences for engagement and information: A segmentation analysis

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Elizabeth Virginia Hobman, Aditi Mankad, Lucy Carter, Kerry Collins,  Frontiers in Bioengineering and Biotechnology,  12. 2024.
This research focusses on understanding (1) how people perceive genetic technology to control invasive animal pests (feral pigs, cats etc.), and (2) how people would like to be engaged on, and/or informed about, decisions regarding the development of this genetic technology. The ...

Biased social chromosome transmission in males of the fire ant Solenopsis invicta

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Daniel R Hettesheimer, Haolin Zeng, Brendan G Hunt, Kenneth G Ross,  G3: Genes|Genomes|Genetics,  2024.
Selfish genetic elements subvert the normal rules of inheritance to unfairly propagate themselves, often at the expense of other genomic elements and the fitness of individuals carrying them. Social life provides diverse avenues for the propagation of such elements. In the fire ...

Assessing the Efficacy of Gene-Drive Technology in Reducing Malaria Transmission in Sub-Saharan Africa: Current Progress and Future Prospects

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Bizimana Rukundo T.,  IAA Journal of Applied Sciences,  12(1):1-5. 2024.
Malaria continues to pose a significant public health challenge in Sub-Saharan Africa, necessitating innovative solutions to combat its transmission. This review examined the efficacy of gene-drive technology as a novel approach to reducing malaria transmission through genetic ...

A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring

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Yu Hua, Jianxiu Zhang, et al.,  PNAS,  121. 2024.
Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing meiotic products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of ...

Structural duality enables a single protein to act as a toxin–antidote pair for meiotic drive

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Yu Hua, Jianxiu Zhang, et al.,  PNAS,  121. 2024.
In sexual reproduction, selfish genetic elements known as killer meiotic drivers (KMDs) bias inheritance by eliminating gametes that do not carry them. The selective killing behavior of most KMDs can be explained by a toxin–antidote model, where a toxin harms all gametes while ...

Exploring The Dynamics of Gene Drive Mosquitoes Within Wild Populations Using an Agent-Based Simulation

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S. Wickramasooriya, I. Mahmood, et al.,  IEEE Xplore,  2024.
Gene drive technology is emerging as a potentially powerful tool in combating vector-borne diseases – notably malaria. This study introduces an agent-based model (ABM) focused on the deployment of genetically engineered mosquitoes with gene drive (GEM) in Príncipe Island, ...

The Meiotic Drive: Intragenomic Competition and Selection

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I. A. Zakharov,  Russian Journal of Genetics,  60:1311-1318. 2024.
The article considers the distribution and mechanisms of the meiotic drive as a phenomenon manifested in unequal transmission of gene alleles and/or homologous chromosomes into gametes during meiosis. The meiotic drive has been studied in the most detail in Drosophila, mice, ...

Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti

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Brittany L. Dodson, Sujit Pujhari, et al.,  PLoS Neglected Tropical Diseases,  2024.
Wolbachia pipientis (= Wolbachia) has promise as a tool to suppress virus transmission by Aedes aegypti mosquitoes. However, Wolbachia can have variable effects on mosquito-borne viruses. This variation remains poorly characterized, yet the multimodal effects of Wolbachia on ...

Biotechnology-enhanced genetic controls of the global pest Drosophila suzukii

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Ying Yan, Hassan M.M. Ahmed, Ernst A. Wimmer, et al.,  Trends in Biotechnology,  2024.
Genetic control is a biological control method that introduces traits that sterilize, kill, or modify the population via intraspecific mating. Therefore, it is regarded as a species-specific and environmentally friendly management option for pest species. Spotted wing ...

Improving the suppressive power of homing gene drive by co-targeting a distant-site female fertility gene

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Faber, N.R., Xu, X., Chen, J. et al.,  Nature Communications,  15. 2024.
Gene drive technology has the potential to address major biological challenges. Well-studied homing suppression drives have been shown to be highly efficient in Anopheles mosquitoes, but for other organisms, lower rates of drive conversion prevent elimination of the target ...

Navigating biosafety regulatory frameworks for genetic engineering in Africa: a focus on genome editing and gene drive technologies

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Tilahun Rabuma, Felix Moronta-Barrios, Wendy Craig,  Frontiers in Bioengineering and Biotechnology,  12. 2024.
Genome editing and gene drive technologies are increasingly gaining attraction in Africa, with researchers exploring their potential applications in agriculture, health and the environment. Acknowledging that robust regulatory frameworks are crucial in facilitating the ...

Engineering Resilient Gene Drives Towards Sustainable Malaria Control: Predicting, Testing and Overcoming Target Site Resistance

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Ioanna Morianou, Lee Phillimore, Bhavin S. Khatri,,  bioRxiv,  2024.
CRISPR-based gene drives are selfish genetic elements with the potential to spread through entire insect populations for sustainable vector control. Gene drives designed to disrupt the reproductive capacity of females can suppress laboratory populations of the malaria mosquito. ...

Pest control gets the CRISPR treatment

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Seydel, C.,  Nature Biotechnology,  2024.
In June 2024, the St. Louis–based pest control company Agragene released genetically modified fruit flies on berry farms in California and Oregon, moving the technology out of the laboratory and into contained field testing. The trial marked a milestone for a next-generation ...

Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions?

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Matthew V Rockman,  Genetics,  2024.
Self-fertile Caenorhabditis nematodes carry a surprising number of Medea elements, alleles that act in heterozygous mothers and cause death or developmental delay in offspring that don’t inherit them. At some loci, both alleles in a cross operate as independent Medeas, ...

Exploring The Dynamics of Gene Drive Mosquitoes Within Wild Populations Using an Agent-Based Simulation

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S. Wickramasooriya, I. Mahmood, A. Calinescu, M. Wooldridge and G. Lanzaro,  2024 Annual Modeling and Simulation Conference,  Washington, D.C.:1-14. 2024.
Gene drive technology is emerging as a potentially powerful tool in combating vector-borne diseases – notably malaria. This study introduces an agent-based model (ABM) focused on the deployment of genetically engineered mosquitoes with gene drive (GEM) in Príncipe Island, ...

Stalk-eyed flies carrying a driving X chromosome compensate by increasing fight intensity

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Kimberly A. Paczolt, Macy E. Pritchard, Gabrielle T. Welsh, et al.,  Frontiers in Ethology,  3. 2024.
Exaggerated ornaments provide opportunities to understand how selection can operate at different levels to shape the evolution of a trait. While these features aid their bearer in attracting mates or fending off competitors, they can also be costly and influenced by the ...

Wolbachia Invasion in Mosquitoes with Incomplete CI, Imperfect Maternal Transmission and Maturation Delay

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Ma X, Su Y,  Bulletin of Mathematical Biology,  2024.
The mechanism of cytoplasmic incompatibility (CI) is important in the study of Wolbachia invasion in wild mosquitoes. Su et al. (Bull Math Biol 84(9):95, 2022) proposed a delay differential equation model by relating the CI effect to maturation delay. In this paper, we ...

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