Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
Disclaimer>

A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives

Tags: ,
M. I. Tek and K. Budak,  Frontiers in Plant Science,  13. 2022.
CRISPR drive is a recent and robust tool that allows durable genetic manipulation of the pest population like human disease vectors such as malaria vector mosquitos. In recent years, it has been suggested that CRISPR drives can also be used to control plant diseases, pests, and ...

Pilot trial using mass field-releases of sterile males produced with the incompatible and sterile insect techniques as part of integrated Aedes aegypti control in Mexico

Tags: , , , ,
A. Martín-Park, A. Che-Mendoza, Y. Contreras-Perera, S. Pérez-Carrillo, H. Puerta-Guardo, J. Villegas-Chim, G. Guillermo-May, A. Medina-Barreiro, H. Delfín-González, R. Méndez-Vales, S. Vázquez-Narvaez, J. Palacio-Vargas, F. Correa-Morales, G. Ayora-Tal,  PLoS Negl Trop Dis,  16:e0010324. 2022.
We implemented a controlled before-and-after quasi-experimental study in two suburban localities of Yucatan (Mexico): San Pedro Chimay (SPC), which received IIT-SIT, and San Antonio Tahdzibichén used as control. Release of wAlbB Ae. aegypti males at SPC extended for 6 months ...

Recent advancements in CRISPR/Cas technology for accelerated crop improvement

Tags: , ,
D. Das, D. L. Singha, R. R. Paswan, N. Chowdhury, M. Sharma, P. S. Reddy and C. Chikkaputtaiah,  Planta,  255:109. 2022.
The likelihood of reduced agricultural production due to highly turbulent climatic conditions increases as the global population expands. The second paradigm of stress-resilient crops with enhanced tolerance and increased productivity against various stresses is paramount to ...

Biotechnological Road Map for Innovative Weed Management

Tags: , , ,
A. C. S. Wong, K. Massel, Y. Lam, J. Hintzsche and B. S. Chauhan,  Frontiers in Plant Science,  13. 2022.
In most agriculture farmlands, weed management is predominantly reliant on integrated weed management (IWM) strategies, such as herbicide application. However, the overuse and misuse of herbicides, coupled with the lack of novel active ingredients, has resulted in the uptrend of ...

The evolutionary significance of meiotic drive

Tags: , ,
J. B. Searle and F. P.-M. de Villena,  Heredity,  2022.
In this essay, we will focus on‘true meiotic drive’ where the distorted transmission does arise within meiosis itself (Zanders and Unckless2019),specifically in females. Here, the non-transmission of one of the products of meiotic division is inherent in the gametogenic ...

Role of CRISPR Technology in Gene Editing of Emerging and Re-emerging Vector Borne Disease

Tags: , , , ,
K. K. Mahto, P. Prasad, M. Kumar, H. Dubey and A. Ranjan,  Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies,  2022.
Vector borne diseases are rampant across the world. Due to spread and estab-lishment of vector species in different geographical areas, vector adaptation and resistance towards many insecticides the only option left is vector control for vari-ous vector borne diseases. Recent ...

Wolbachia endosymbionts in two Anopheles species indicates independent acquisitions and lack of prophage elements

Tags: , , , ,
S. Quek, L. Cerdeira, C. L. Jeffries, S. Tomlinson, T. Walker, G. L. Hughes and E. Heinz,  Microbial Genomics,  8. 2022.
Wolbachia is a genus of obligate bacterial endosymbionts that infect a diverse range of arthropod species as well as filarial nematodes, with its single described species, Wolbachia pipientis, divided into several ‘supergroups’ based on multilocus sequence typing. Wolbachia ...

Aedes aegypti abundance and insecticide resistance profiles in the applying Wolbachia to eliminate dengue trial

Tags: , , ,
W. Tantowijoyo, S. K. Tanamas, I. Nurhayati, S. Setyawan, N. Budiwati, I. Fitriana, I. Ernesia, D. S. Wardana, E. Supriyati, E. Arguni, Y. Meitika, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, E. Rancès, P. A. Ryan, S. L. O'Neill, K. L. Anders, M. R. A,  PLOS Neglected Tropical Diseases,  16:e0010284. 2022.
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative ...

A metapopulation approach to identify targets for Wolbachia-based dengue control

Tags: , , , , ,
A. Reyna-Lara, D. Soriano-Paños, J. H. Arias-Castro, H. J. Martínez and J. Gómez-Gardeñes,  Chaos,  32:041105. 2022.
Over the last decade, the release of Wolbachia-infected Aedes aegypti into the natural habitat of this mosquito species has become the most sustainable and long-lasting technique to prevent and control vector-borne diseases, such as dengue, zika, or chikungunya. However, the ...

Environmental factors influence the local establishment of Wolbachia in Aedes aegypti mosquitoes in two small communities in central Vietnam [version 2]

Tags: , ,
N. T. Hien, D. D. Anh, N. H. Le, N. T. Yen, T. V. Phong, V. S. Nam, T. N. Duong, N. B. Nguyen, D. T. T. Huong, L. Q. Hung, C. N. T. Trinh, N. V. Hoang, V. Q. Mai, L. T. Nghia, N. T. Dong, L. H. Tho, S. Kutcher, T. P. Hurst, J. L. Montgomery, M. Woolfit, E,  Gates Open Research,  5:147. 2022.
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown to reduce transmission of dengue and other pathogens, under both laboratory and field conditions. Here we describe the entomological outcomes of wMel ...

The sterile insect technique is protected from evolution of mate discrimination

Tags: , , , ,
J. J. Bull and R. Gomulkiewicz,  PeerJ,  10:e13301. 2022.
Background The sterile insect technique (SIT) has been used to suppress and even extinguish pest insect populations. The method involves releasing artificially reared insects (usually males) that, when mating with wild individuals, sterilize the broods. If administered on a large ...

Propagation of seminal toxins through binary expression gene drives could suppress populations

Tags: , , , , ,
J. Hurtado, S. Revale and L. M. Matzkin,  Scientific Reports,  12:6332. 2022.
Gene drives can be highly effective in controlling a target population by disrupting a female fertility gene. To spread across a population, these drives require that disrupted alleles be largely recessive so as not to impose too high of a fitness penalty. We argue that this ...

Mendelian nightmares: the germline-restricted chromosome of songbirds

Tags: , ,
P. Borodin, A. Chen, W. Forstmeier, S. Fouché, L. Malinovskaya, Y. Pei, R. Reifová, F. J. Ruiz-Ruano, S. A. Schlebusch, M. Sotelo-Muñoz, A. Torgasheva, N. Vontzou and A. Suh,  Chromosome Res,  2022.
Germline-restricted chromosomes (GRCs) are accessory chromosomes that occur only in germ cells. They are eliminated from somatic cells through programmed DNA elimination during embryo development. GRCs have been observed in several unrelated animal taxa and show peculiar modes of ...

Meiotic drive in chronic lymphocytic leukemia compared with other malignant blood disorders

Tags:
V. Jonsson, H. Awan, N. D. Jones, T. B. Johannesen, K. Thogersen, B. A. Steig, G. Andorsdottir and G. E. Tjonnfjord,  Scientific Reports,  12:6138. 2022.
The heredity of the malignant blood disorders, leukemias, lymphomas and myeloma, has so far been largely unknown. The present study comprises genealogical investigations of one hundred and twelve Scandinavian families with unrelated parents and two or more cases of malignant ...

The non-Mendelian behavior of plant B chromosomes

Tags: , ,
J. Chen, J. A. Birchler and A. Houben,  Chromosome Res,  2022.
B chromosomes, also known as supernumerary chromosomes, are dispensable elements in the genome of many plants, animals, and fungi. Many B chromosomes have evolved one or more drive mechanisms to transmit themselves at a higher frequency than predicted by Mendelian genetics, and ...

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

Tags: , , , , ,
E. Yang, M. Metzloff, A. M. Langmuller, X. J. Xu, A. G. Clark, P. W. Messer and J. Champer,  G3-Genes Genomes Genetics,  13. 2022.
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to spread throughout a population. They could potentially be used to modify or suppress pest populations, such as mosquitoes that spread diseases. CRISPR/Cas9 homing drives, which copy ...

Cas9-mediated maternal-effect and derived resistance alleles in a gene-drive strain of the African malaria vector mosquito, Anopheles gambiae

Tags: , , , , ,
R. Carballar-Lejarazú, T. Tushar, T. B. Pham and A. A. James,  Genetics,  2022.
CRISPR/Cas9 technologies are important tools for the development of gene-drive systems to modify mosquito vector populations to control the transmission of pathogens that cause diseases such as malaria. However, one of the challenges for current Cas9-based drive systems is their ...

A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso

Tags: , ,
L. Pare Toe, N. Barry, A. D. Ky, S. Kekele, W. I. Meda, K. Bayala, et al.,  Humanities and Social Sciences Communications,  9. 2022.
Genetic engineering is a complex topic, even for scientists working in other areas, and even more so for those who lack a formal scientific training. To help gene specialists and affected communities talk with one another, international guidance documents have been published that ...

Governing Gene Drive Technologies: A Qualitative Interview Study

Tags: , , , ,
N. de Graeff, K. R. Jongsma, J. E. Lunshof and A. L. Bredenoord,  AJOB Empirical Bioethics,  13:107-124. 2022.
Gene drive technologies (GDTs) bias the inheritance of a genetic element within a population of non-human organisms, promoting its progressive spread across this population. If successful, GDTs may be used to counter intractable problems such as vector-borne diseases. A key issue ...

Expanding the flexibility of genome editing approaches for population control of the malaria mosquito

Tags: , , ,
N. Kranjc,  Imperial College London-PhD,  2022.
Discovery and adaptation of CRISPR-Cas systems for genome editing have allowed us to gain an efficient and yet simple tool for genetic manipulation in various fields of molecular biology and biotechnology. One of the most promising applications is the use of CRISPR-Cas9 ...

« First ‹ Previous 1 33 41 42 43 44 45 53 118 Next › Last »