Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Strategies to Mitigate Establishment under the Wolbachia Incompatible Insect Technique

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S. Soh, S. H. Ho, J. Ong, A. Seah, B. S. Dickens, K. W. Tan, J. R. Koo, A. R. Cook, S. Sim, C. H. Tan, L. C. Ng and J. T. Lim,  Viruses,  14. 2022.
The Incompatible Insect Technique (IIT) strategy involves the release of male mosquitoes infected with the bacterium Wolbachia. Regular releases of male Wolbachia-infected mosquitoes can lead to the suppression of mosquito populations, thereby reducing the risk of transmission of ...

Novel molecular approaches to combat vectors and vector-borne viruses: Special focus on RNA interference (RNAi) mechanisms

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A. Agarwal, D. K. Sarma, D. Chaurasia and H. S. Maan,  Acta Tropica,  2022.
Vector-borne diseases, such as dengue, chikungunya, zika, yellow fever etc pose significant burden among the infectious diseases globally, especially in tropical and sub-tropical regions. Globalization, deforestation, urbanization, climate change, uncontrolled population growth, ...

Quality Control and Mating Performance of Irradiated Glossina palpalis gambiensis Males

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K. Ilboudo, K. Camara, E. W. Salou and G. Gimonnea,  Insects,  13. 2022.
The biological quality of sterile male insects produced in a mass-rearing facility is a prerequisite for the success of the SIT, which is a component of area-wide integrated pest management (AW-IPM). Indeed, sterile male insects released in the field must have a good mating ...

Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes

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P. B. Patil, S. K. Dasgupta, K. Gorman, A. Pickl-Herk, M. Puinean, A. McKemey, B. Char, U. B. Zehr and S. R. Barwale,  PLOS Neglected Tropical Diseases,  16:e0010315. 2022.
Author summary Aedes aegypti L. species is the primary vector responsible for transmission of the dengue virus worldwide including chikungunya, yellow fever and Zika virus. The experiment presented in the manuscript represents a study undertaken to demonstrate suppression of the ...

Bayesian network-based risk assessment of synthetic biology: Simulating CRISPR-Cas9 gene drive dynamics in invasive rodent management

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E. A. Brown, S. R. Eikenbary and W. G. Landis,  Risk Analysis,  2022.
Gene drive technology has been proposed to control invasive rodent populations as an alternative to rodenticides. However, this approach has not undergone risk assessment that meets criteria established by Gene Drives on the Horizon, a 2016 report by the National Academies of ...

Aquatic invasive species specialists’ perceptions on the importance of genetic tools and concepts to inform management

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T. A. Bernos, K. M. Jeffries and N. E. Mandrak,  Biological Invasions,  24:1863-1879. 2022.
Perceptions related to the importance of genetic research influence the mobilization of genetic tools and concepts to inform conservation actions. Research characteristics, stakeholders’ perspectives, knowledge, and social linkages with geneticists influence the outcome of ...

Simple, sensitive, and cost-effective detection of wAlbB Wolbachia in Aedes mosquitoes, using loop mediated isothermal amplification combined with the electrochemical biosensing method

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P. Thayanukul, B. Lertanantawong, W. Sirawaraporn, S. Charasmongkolcharoen, T. Chaibun, R. Jittungdee and P. Kittayapong,  PLOS Neglected Tropical Diseases,  16:e0009600. 2022.
Author summary Mosquito-borne diseases such as dengue, chikungunya, zika, and yellow fever are transmitted to humans mainly by the bites of Aedes aegypti mosquitoes. Controlling the vectors of these diseases relies mostly on the use of insecticides. However, the efficiency has ...

Intronic gRNAs for the Construction of Minimal Gene Drive Systems

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A. Nash, P. Capriotti, A. Hoermann, P. A. Papathanos and N. Windbichler,  Frontiers in Bioengineering and Biotechnology,  10. 2022.
Gene drives are promising tools for the genetic control of insect vector or pest populations. CRISPR-based gene drives are generally highly complex synthetic constructs consisting of multiple transgenes and their respective regulatory elements. This complicates the generation of ...

Lessons learned from the introduction of genetically engineered crops: relevance to gene drive deployment in Africa

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H. Quemada,  Transgenic Res,  2022.
The application of gene drives to achieve public health goals, such as the suppression of Anopheles gambiae populations, or altering their ability to sustain Plasmodium spp. infections, has received much attention from researchers. If successful, this genetic tool can contribute ...

Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles

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A. L. Bishop, V. López Del Amo, E. M. Okamoto, Z. Bodai, A. C. Komor and V. M. Gantz,  Nat Commun,  13:2595. 2022.
Homing CRISPR gene drives could aid in curbing the spread of vector-borne diseases and controlling crop pest and invasive species populations due to an inheritance rate that surpasses Mendelian laws. However, this technology suffers from resistance alleles formed when the ...

Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models

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Y. Liu, W. Teo, H. Yang and J. Champer,  bioRxiv,  2022.05.08.491087. 2022.
Suppression gene drives are designed to bias their inheritance and increase in frequency in a population, disrupting an essential gene in the process. When the frequency is high enough, the population will be unable to reproduce above the replacement level and could be ...

Local adaptation of Aedes aegypti mosquitoes to Wolbachia-induced fitness costs

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P. A. Ross and A. A. Hoffmann,  bioRxiv,  2022.05.06.490959. 2022.
Aedes aegypti mosquito eggs can remain quiescent for many months before hatching, allowing populations to persist through unfavorable conditions. Aedes aegypti infected with the Wolbachia strain wMel have been released in tropical and subtropical regions for dengue control. wMel ...

The principles driving gene drives for conservation

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S. Hartley, R. Taitingfong and P. Fidelman,  Environmental Science and Policy,  135:36-45. 2022.
Gene drive technology is an emerging biotechnology with the potential to address some of the most intractable global biodiversity conservation issues. Scientists are exploring potential gene drive applications for managing invasive species and building resilience in keystone ...

Transient Introgression of Wolbachia into Aedes aegypti Populations Does Not Elicit an Antibody Response to Wolbachia Surface Protein in Community Members

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E. Lee, T. Hien Nguyen, T. Yen Nguyen, S. Nam Vu, N. Duong Tran, L. Trung Nghia, Q. Mai Vien, T. Dong Nguyen, R. Kriiger Loterio, I. Iturbe-Ormaetxe, H. A. Flores, S. L. O'Neill, D. Anh Dang, C. P. Simmons and J. E. Fraser,  Pathogens,  11. 2022.
Wolbachia is an endosymbiotic bacterium that can restrict the transmission of human pathogenic viruses by Aedes aegypti mosquitoes. Recent field trials have shown that dengue incidence is significantly reduced when Wolbachia is introgressed into the local Ae. aegypti population. ...

New weapons to fight malaria transmission: A historical view

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W. Huang, S.-J. Cha and M. Jacobs-Lorena,  Entomological Research,  2022.
The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of ...

International shipments of Wolbachia-infected mosquito eggs: towards the scaling-up of World Mosquito Program operations

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J. A. Denton, D. A. Joubert, A. A. Goundar and J. R. L. Gilles,  Scientific and Technical Review,  41:91-99. 2022.
The Wolbachia insect control method, employed by the World Mosquito Program (WMP), relies on introgressing Wolbachia through target Aedes aegypti populations to reduce the incidence of dengue. Since 2010, the WMP has been producing Wolbachia-infected mosquitoes at numerous sites ...

The fate of a suppressed X-linked meiotic driver: experimental evolution in Drosophila simulans

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H. Bastide, D. Ogereau, C. Montchamp-Moreau and P. R. Gérard,  Chromosome Research,  2022.
Sex-ratio (SR) meiotic drivers are X-linked selfish genetic elements that promote their own transmission by preventing the production of Y-bearing sperm, which usually lowers male fertility. The spread of SR drivers in populations is expected to trigger the evolution of unlinked ...

Epistatic selection on a selfish Segregation Distorter supergene: drive, recombination, and genetic load

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B. Navarro-Dominguez, C.-H. Chang, C. L. Brand, C. A. Muirhead, D. C. Presgraves and A. M. Larracuente,  eLife,  11:e78981. 2022.
In this work, we investigate the evolution and genomic consequences of an autosomal, multilocus, male meiotic drive system, Segregation Distorter (SD) in the fruit fly, Drosophila melanogaster. In African populations, the predominant SD chromosome variant, SD-Mal, is ...

CRISPR/Cas9 mediates efficient site-specific mutagenesis of the odorant receptor co-receptor (Orco) in the malaria vector Anopheles sinensis

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Y. Wang, X. F. He, L. Qiao, Z. R. Yu, B. Chen and Z. B. He,  Pest Management Science,  11. 2022.
BACKGROUND Anopheles sinensis is the most widely distributed mosquito species and is the main transmitter of Plasmodium vivax malaria in China. Most previous research has focused on the mechanistic understanding of biological processes in An. sinensis and novel ways of ...

Engineering a self-eliminating transgene in the yellow fever mosquito, Aedes aegypti

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K. Chae, C. Dawson, C. Valentin, B. Contreras, J. Zapletal, K. M. Myles and Z. N. Adelman,  PNAS Nexus,  2022.
Promising genetics-based approaches are being developed to reduce or prevent the transmission of mosquito-vectored diseases. Less clear is how such transgenes can be removed from the environment, a concern that is particularly relevant for highly invasive gene drive transgenes. ...

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