Scholarly Literature
This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives). The latest are shown here.
Disclaimer>
Procedurally Robust Risk Assessment Framework for Novel Genetically Engineered Organisms and Gene Drives
Tags: Gene drive synthetic, Gene editing, Genetically modified organisms, Governance, Policy, Risk assessmentKuzma, J., Regulation and Governance, 15:1144-1165. 2021.
In this article, a new framework for improving risk assessments of novel genetically engineered organisms (GEOs) is developed and applied. The Procedurally Robust Risk Assessment Framework (PRRAF) provides a set of principles and criteria for assessing and enhancing risk ...
CRISPR-based gene drives for combatting malaria: Need for an early stage technology assessment.
Tags: Gene drive synthetic, Policy, Regulation, Risk assessmentLiebert, W., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The potential power of CRISPR-based gene drives makes it necessary to engage in science and technology assessment already in early stages of research and development. In order to argue for efforts to address this urgent need, gene drives to combat malaria-transmitting mosquitoes ...
AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application
Tags: Gene drive synthetic, Incompatible insect technique, Sterile insect technique (SIT)Hendrichs, J. Pereira, R., Vreysen, M. J. B., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The concept of area-wide integrated pest management (AW-IPM), in which the total population of a pest in an area is targeted, is central to the effective control of such populations through the integration of genetic, biological and other pest suppression technologies. Insect ...
Synthetic sex ratio distorters based on CRISPR for the control of harmful insect populations
Tags: Chromosomal drive, Gene drive synthetic, Transmission distortion, Y-chromosomeFasulo, B., Meccariello, A., Papathanos, P. A., and Windbichler, N., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
Since the overall reproductive output of a population is typically determined by the fertility of its females, which are rate-limiting in gamete production, a successful way to genetically control a population should involve artificially biasing the sex ratio towards males. In ...
Combined sterile insect technique and incompatible insect technique: concept, study design, experience and lessons learned from a pilot suppression trial in Thailand
Tags: Aedes, Cytoplasmic incompatibility, Incompatible insect technique, Sterile insect technique (SIT), WolbachiaKittayapong, P., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
Climate change, rapid global transport and land use change leading to urbanization and agricultural intensification have facilitated disease emergence in vulnerable regions like Southeast Asia, and also the global expansion of vectors and vector-borne diseases into other regions ...
Barriers and facilitators of area-wide management including sterile insect technique application: The example of Queensland fruit fly
Tags: Genetic biocontrol, Incompatible insect technique, Policy, Stakeholder engagement, Sterile insect technique (SIT)Mankad, A., Loechel, B., and Measham, P. F., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The area-wide management (AWM) of highly mobile insect pests such as tephritid fruit flies requires an integrated understanding of technical, social and institutional processes that drive a coordinated approach within a defined area. Furthermore, the success of an AWM programme ...
Putting the sterile insect technique into the modern integrated pest management toolbox to control the codling moth in Canada
Tags: Moths, Sterile insect technique (SIT)Nelson, C., Esch, E., Kimmie, S., Tesche, M., and Philip, H. Arthur, S., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The Okanagan-Kootenay Sterile Insect Release (OKSIR) programme, in southern British Columbia, Canada, has been successfully applying the Sterile Insect Technique (SIT) as part of a sustainable areawide integrated pest management (AW-IPM) programme to control the codling moth ...
Ecology, behaviour and area-wide control of the floodwater mosquito Aedes sticticus, with potential of future integration of the sterile insect technique
Tags: Aedes, Incompatible insect technique, Sterile insect technique (SIT)Lundstrom, J. O. Schafer, M. L. Kittayapong, P., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The strategy of aerial control of the floodwater mosquito Aedes sticticus (Meigen) in the floodplains of River Dalalven, central Sweden, was developed to directly address specific larval breeding areas in temporary flooded wet meadows and swamps. Using the Bti-based larvicide ...
Area-wide management of mediterranean fruit fly with the sterile insect technique in South Africa: New production and management techniques pay dividends
Tags: Africa, Fruit fly, Sterile insect technique (SIT)Venter, J. H., Baard, C. W. L., and Barnes, B. N., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
A mass-rearing facility to produce sterile male Mediterranean fruit flies, Ceratitis capitata (Wiedemann), for a Sterile Insect Technique (SIT) programme in the Hex River Valley in the Western Cape Province started in the late 1990s. The programme was initially underfunded and ...
The suppression of the False Codling Moth in South Africa using an AW-IPM approach with a SIT component
Tags: Africa, Genetic biocontrol, Sterile insect technique (SIT)N. Boersma, AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The false codling moth, Thaumatotibia leucotreta (Meyrick) (Lepidoptera: Tortricidae), is native to subSaharan Africa, where it infests various commercial, and wild, fruit-bearing plants. This major pest is not present in the Americas, Europe, and Asia, and therefore has ...
Wolbachia cifB induces cytoplasmic incompatibility in the malaria mosquito vector
Tags: Anopheles, Cytoplasmic incompatibility, Genetically modified mosquitoes, Mosquitoes, WolbachiaK. L. Adams, D. G. Abernathy, B. C. Willett, E. K. Selland, M. A. Itoe and F. Catteruccia, Nature Microbiology, 6:1575-1582. 2021.
Wolbachia, a maternally inherited intracellular bacterial species, can manipulate host insect reproduction by cytoplasmic incompatibility (CI), which results in embryo lethality in crosses between infected males and uninfected females. CI is encoded by two prophage genes, cifA ...
Wolbachia reduces virus infection in a natural population of Drosophila
Tags: Arbovirus, Dengue, Fruit fly, Genetic biocontrol, Other Symbionts, WolbachiaR. Cogni, S. D. Ding, A. C. Pimentel, J. P. Day and F. M. Jiggins, Communications Biology, 4:1327. 2021.
Wolbachia is a maternally transmitted bacterial symbiont that is estimated to infect approximately half of arthropod species. In the laboratory it can increase the resistance of insects to viral infection, but its effect on viruses in nature is unknown. Here we report that in a ...
Propagation of seminal toxins through binary expression gene drives can suppress polyandrous populations
Tags: Gene drive synthetic, Modeling, Population suppression, Self limiting, Sex distorter, Toxin-antidoteJ. Hurtado, S. Revale and L. M. Matzkin, bioRxiv, 2021.11.23.469777. 2021.
Gene drives can be highly effective in controlling a target population by disrupting a female fertility gene. To spread across a population, these drives require that disrupted alleles be largely recessive so as not to impose too high of a fitness penalty. We argue that this ...
Tubulin post-translational modifications in meiosis
Tags: Transmission distortionT. Akera, Seminars in Cell & Developmental Biology, 2021.
Haploid gametes are produced from diploid parents through meiosis, a process inherent to all sexually reproducing eukaryotes. Faithful chromosome segregation in meiosis is essential for reproductive success, although it is less clear how the meiotic spindle achieves this compared ...
Evaluation of Transgenic Aedes aegypti L. Strain in India: A Friendly Mosquito
Tags: Aedes, Dengue, Oxitec, Sterile insect technique (SIT)P. B. Patil, K. K. Yadav, S. K. Dasgupta, U. B. Zehr, S. R. Barwale and B. Char, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Aedes aegypti L. is a primary vector of dengue and is also responsible for transmission of other arboviral diseases including chikungunya, yellow fever, and Zika virus worldwide. India is attributed with as much as 34% of the global burden of dengue infection as per the recent ...
Containment Strategies for Synthetic Gene Drive Organisms and Impacts on Gene Flow
L. Pei and M. Schmidt, GENE FLOW: Monitoring, Modeling and Mitigation, 2021.Gene drives, particularly synthetic gene drives, may help to address some important challenges, by efficiently altering specific sections of DNA in entire populations of wild organisms. Here we review the current development of the synthetic gene drives, especially those ...
Historical perspective and new avenues to control the myiasis-causing fly Cochliomyia hominivorax in Uruguay.
Tags: Gene drive synthetic, Genetic biocontrol, Sterile insect technique (SIT)Fresia P, Pimentel S, Iriarte V, Marques L, Durán V, Saravia A, Novas R, Basika T, Ferenczi A, Castells D, Saporiti T, Cuore U, Losiewicz S, Fernández F, Ciappesoni G, Dalla-Rizza M and M. A., Agrociencia Uruguay, 25:e974. 2021.
Mosca de la bichera’ or simply ‘bichera’ are common names given in Uruguay and the region to the primary myiasis-causing species Cochliomyia hominivorax, the New World Screwworm (NWS) fly (Diptera: Calliphoridae). Myiasis happens when dipteran larvae infest live animals at ...
A Household-Based Survey to Understand Factors Influencing Awareness, Attitudes and Knowledge towards Wolbachia-Aedes Technology
Tags: Dengue, Genetic biocontrol, Policy, Stakeholder engagement, WolbachiaL. T. Soh, Z. Ong, K. Vasquez, I. Chen, X. Li, W. Niah, C. Panchapakesan, A. Sheldenkar, S. Sim, L. C. Ng and M. O. Lwin, International Journal of Environmental Research and Public Health, 18. 2021.
In 2016, Singapore introduced the release of male Wolbachia-Aedes mosquitoes to complement vector control efforts and suppress Aedes aegypti mosquitoes in selected study sites. With ongoing expansion of Project Wolbachia-Singapore to cover larger areas, a household-based survey ...
High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoes
Tags: Anopheles, CRISPR, Gene drive synthetic, Population modification/replacement, Population suppressionG. Terradas, A. Hermann, A. A. James, W. McGinnis and E. Bier, G3-Genes Genomes Genetics, 2021.
Gene drives are programmable genetic elements that can spread beneficial traits into wild populations to aid in vector-borne pathogen control. Two different drives have been developed for population modification of mosquito vectors. The Reckh drive (vasa-Cas9) in Anopheles ...
Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line
Tags: Genetic incompatibilities, Rodents, Transmission distortionD. Arends, S. Kärst, S. Heise, P. Korkuc, D. Hesse and G. A. Brockmann, Genetics, 2021.
While direct additive and dominance effects on complex traits have been mapped repeatedly, additional genetic factors contributing to the heterogeneity of complex traits have been scarcely investigated. To assess genetic background effects, we investigated transmission ratio ...
Contact Us
Alex Sullivan
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org