Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Gene conversion generates evolutionary novelty that fuels genetic conflicts

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Daugherty, MDZ, Sarah E.,  Current Opinion in Genetics & Development,  58-59:49-54. 2019.
Genetic conflicts arise when the evolutionary interests of two genetic elements are not aligned. Conflicts between genomes (e.g. pathogen versus host) or within the same genome (e.g. internal parasitic DNA sequences versus the rest of the host genome) can both foster ‘molecular ...

Informed consent and community engagement in open field research: lessons for gene drive science

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Singh, JA,  BMC Medical Ethics,  20:54. 2019.
The development of the CRISPR/Cas9 gene editing system has generated new possibilities for the use of gene drive constructs to reduce or suppress mosquito populations to levels that do not support disease transmission. Despite this prospect, social resistance to genetically ...

Next-generation CRISPR-based gene drive supports genetic editing with selective precision

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Anonymous,  International Sugar Journal,  121:411-412. 2019.
New CRISPR-based gene drives and broader active genetics technologies are revolutionizing the way scientists engineer the transfer of specific traits from one generation to another.

Two minutes to midnight-what international law can do about genome editing

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Lee, TL,  Asian Journal of Wto & International Health Law and Policy,  14:227-265. 2019.
With its ability to transform the ecosystem, gene drives, a powerful genome-editing technology, poses nuanced regulatory challenges. In particular, as gene drives can override the normal rule of inheritance, where the impacts of gene-drive modified organisms on the environment ...

Alternative strategies for mosquito-borne arbovirus control

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Achee, NLG, J. P.; Vatandoost, H.; Seixas, G.; Pinto, J.; Ching-Ng, L.; Martins, A. J.; Juntarajumnong, W.; Corbel, V.; Gouagna, C.; David, J. P.; Logan, J. G.; Orsborne, J.; Marois, E.; Devine, G. J.; Vontas, J.,  PLOS Neglected Tropical Diseases,  13:e0006822. 2019.
Mosquito-borne virusessuch as Zika, chikungunya, dengue fever, and yellow fever, among othersare of global importance. Although vaccine development for prevention of mosquito-borne arbovirus infections has been a focus, mitigation strategies continue to rely on vector control. ...

Biocontrol in Australia: Can a carp herpesvirus (CyHV-3) deliver safe and effective ecological restoration?

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Kopf, RKB, M.; Finlayson, C. M.; Hodges, K.; Humphries, P.; King, A.; Kingsford, R. T.; Marshall, J.; McGinness, H. M.; Thresher, R.; Vanderplasschen, A.,  Biological Invasions,  21:1857-1870. 2019.
The Australian Government is considering Cyprinid herpesvirus 3 (CyHV-3) for biocontrol of invasive common carp (Cyprinus carpio L.). We review the evidence-base for its potential ecological risks, benefits and effectiveness. Lower carp abundance may boost native fish biomass and ...

Evaluating the Probability of CRISPR-based Gene Drive Contaminating Another Species

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Courtier-Orgogozo, VD, Antoine; Gouyon, Pierre-Henri; Boëte, Christophe,  bioRxiv,  776609:27. 2019.
The probability D that a given CRISPR-based gene drive element contaminates another, non-target species can be estimated by the following Drive Risk Assessment Quantitative Estimate (DRAQUE) Equation: D = (hyb+transf).express.cut.flank.immune.nonextinct withhyb = probability of ...

Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila

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Shropshire, JDB, S. R.,  PLOS Genetics,  15:e1008221. 2019.
Wolbachia are maternally inherited bacteria that infect arthropod species worldwide and are deployed in vector control to curb arboviral spread using cytoplasmic incompatibility (CI). CI kills embryos when an infected male mates with an uninfected female, but the lethality is ...

An introduction to the proceedings of the environmental release of engineered pests: Building an international governance framewor

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Brown, Z. S., L. Carter and F. Gould,  BMC Proceedings,  12:10. 2018.
In October 2016, a two-day meeting of 65 academic, government and industry professionals was held at North Carolina State University for early-stage discussions about the international governance of gene drives: potentially powerful new technologies that can be used for the ...

Towards inclusive social appraisal: risk, participation and democracy in governance of synthetic biology

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Stirling, A., K. R. Hayes and J. Delborne,  BMC Proceedings,  12:15. 2018.
Frameworks that govern the development and application of novel products, such as the products of synthetic biology, should involve all those who are interested or potentially affected by the products. The governance arrangements for novel products should also provide a ...

Public engagement pathways for emerging GM insect technologies

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Burgess, M. M., J. D. Mumford and J. V. Lavery,  BMC Proceedings,  12(Suppl 8):12. 2018.
Policy and management related to the release of organisms generated by emerging biotechnologies for pest management should be informed through public engagement. Regulatory decisions can be conceptually distinguished into the development of frameworks, the assessment of the ...

GM insect pests under the Brazilian regulatory framework: development and perspectives

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Andrade, P. P., M. A. da Silva Ferreira, M. S. Muniz and A. de Casto Lira-Neto,  BMC Proceedings,  12:15. 2018.
The emergence of new technologies for genetic modification has broadened the range of possible new products. The regulations of many countries that could benefit from these new products may not be prepared to assess risks and enable science-based decision-making. This is ...

Regulation of emerging gene technologies in India

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Ahuja, V.,  BMC Proceedings,  12:14. 2018.
In India, genetically modified organisms (GMOs) and the products thereof are regulated under the “Rules for the manufacture, use, import, export & storage of hazardous microorganisms, genetically engineered organisms or cells, 1989” (referred to as Rules, 1989) notified under ...

Gene drive research: Why it matters

The Royal Society,  Royal Society Statement,  2018.
Gene drives are systems that bias the inheritance of a particular DNA sequence. Many such systems occur naturally and scientists are now investigating the potential to develop new ones using synthetic biology techniques. Synthetic gene drives are being developed for a range of ...

Ecological effects on underdominance threshold drives for vector control

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D. Khamis, C. El Mouden, K. Kura and M. B. Bonsall,  Journal of Theoretical Biology,  456:1-15. 2018.
Here, ecological and epidemiological dynamics are coupled to a model of mosquito genetics to investigate theoretically the impact of different types of underdominance gene drive on disease prevalence. We model systems with two engineered alleles carried either on the same pair ...

Population Consequences of Releasing Sex-Reversed Fish: Applications and Concerns

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C. Wederkind,  Sex Control in Aquaculture,  Chp 8:179-188. 2018.
Sex differentiation is generally more labile in gonochoristic fish than it is, for example, in birds and mammals. Environmentally induced sex reversal is, therefore, often possible, and creates genotype‐phenotype mismatches that can be useful in population management. ...

Sex Control in Aquaculture: Concept to Practice

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H.P. Wang and Z.G. Shen,  Sex Control in Aquaculture,  2018.
Understanding sex determining (SD) mechanisms and related concepts in a wide range of fish species is critical for sex control and large‐scale monosex production in aquaculture, in which monosex culture is superior to mixed‐sex culture. Establishment of phenotypic sex is ...

Yes we can! Exciting progress and prospects for controlling invasives on islands and beyond

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D. Simberloff, B. Keitt, D. Will, N. Holmes, E. Pickett and P. Genovesi,  Western North American Naturalist,  78:942-958. 2018.
Eradication and maintenance management of island invasive species have long histories, and incremental improvements of existing technologies plus occasional novel approaches have led to more challenging targets and increased success rates in certain categories. Many nonnative ...

Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive

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J. Champer, Z. Wen, A. Luthra, R. Reeves, J. Chung, C. Liu, Y. L. Lee, J. Liu, E. Yang, P. W. Messer and A. G. Clark,  bioRxiv,  447615. 2018.
Gene drives could allow for control of vector-borne diseases by directly suppressing vector populations or spreading genetic payloads designed to reduce pathogen transmission. CRISPR homing gene drives work by cleaving wild-type alleles, which are then converted to drive alleles ...

Invasion Success and Management Strategies for Social Vespula Wasps

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P. J. Lester and J. R. Beggs,  Annual Review of Entomology,  64:51-71. 2018.
Three species of Vespula have become invasive in Australia, Hawai'i, New Zealand, and North and South America and continue to spread. Economically, their main negative effect is associated with pollination and the apicultural industry. Climate change is likely to exacerbate ...

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