Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
Disclaimer>

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Tags: , , , ,
Galizi, RD, L. A.; Menichelli, M.; Bernardini, F.; Deredec, A.; Burt, A.; Stoddard, B. L.; Windbichler, N.; Crisanti, A.,  Nature Communications,  5:3977. 2014.
It has been theorized that inducing extreme reproductive sex ratios could be a method to suppress or eliminate pest populations. Limited knowledge about the genetic makeup and mode of action of naturally occurring sex distorters and the prevalence of co-evolving suppressors has ...

Biased transmission of sex chromosomes in the aphid Myzus persicae is not associated with reproductive mode

Tags: , ,
Wilson, ACCD, R. N.; Vorburger, C.,  PLOS One,  9:1-12. 2014.
Commonly, a single aphid species exhibits a wide range of reproductive strategies including cyclical parthenogenesis and obligate parthenogenesis. Sex determination in aphids is chromosomal; females have two X chromosomes, while males have one. X chromosome elimination at male ...

Concerning RNA-guided gene drives for the alteration of wild populations

Tags: ,
Esvelt, KMS, Andrea L.; Catteruccia, Flaminia; Church, George M.,  eLife,  3:e03401. 2014.
Gene drives may be capable of addressing ecological problems by altering entire; populations of wild organisms, but their use has remained largely theoretical due to technical; constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR; nuclease ...

Sex-ratio meiotic drive and interspecific competition

Tags: ,
Unckless, RLC, A. G.,  Journal of Evolutionary Biology,  27:1513-1521. 2014.
It has long been known that processes occurring within a species may impact the interactions between species. For example, as competitive ability is sensitive to parameters including reproductive rate, carrying capacity and competition efficiency, the outcome of interspecific ...

Genetic control of invasive fish: technological options and its role in integrated pest management

Tags: , , , , , , ,
Thresher, REH, K.; Bax, N. J.; Teem, J.; Benfey, T. J.; Gould, F.,  Biological Invasions,  16:1201-1216. 2014.
Genetic options for the control of invasive fishes were recently reviewed and synthesized at a 2010 international symposium, held in Minneapolis/St. Paul, MN, USA. The only option currently available "off-the-shelf'' is triploidy, which can be used to produce sterile males for a ...

Male eyespan size is associated with meiotic drive in wild stalk-eyed flies (Teleopsis dalmanni)

Tags: , , ,
Cotton, AJF, M.; Cotton, S.; Pomiankowski, A.,  Heredity,  112:363-369. 2014.
This study provides the first direct evidence from wild populations of stalk-eyed flies to support the hypothesis that male eyespan is a signal of meiotic drive. Several stalk-eyed fly species are known to exhibit X-linked meiotic drive. A recent quantitative trait locus analysis ...

A selfish gene chastened: Tribolium castaneum Medea M (4) is silenced by a complementary gene

Tags: , ,
Thomson, MS,  Genetica,  142:161-167. 2014.
Maternal-effect dominant embryonic arrest (Medea) of Tribolium castaneum are autosomal factors that act maternally to cause the death of any progeny that do not inherit them. This selfish behavior is thought to result from a maternally expressed poison and zygotically expressed ...

Centromere strength provides the cell biological basis for meiotic drive and karyotype evolution in mice

Tags: , , , , ,
Chmatal, LG, S. I.; Mitsainas, G. P.; Martinez-Vargas, J.; Ventura, J.; Searle, J. B.; Schultz, R. M.; Lampson, M. A.,  Current Biology,  24:2295-2300. 2014.
Mammalian karyotypes (number and structure of chromosomes) can vary dramatically over short evolutionary time frames [1-3]. There are examples of massive karyotype conversion, from mostly telocentric (centromere terminal) to mostly metacentric (centromere internal), in 102-10 s ...

An X-linked sex ratio distorter in Drosophila simulans that kills or incapacitates both noncarrier sperm and sons

Tags: , ,
Rice, WR,  G3-Genes Genomes Genetics,  4:1837-1848. 2014.
Genomic conflict occurs when a genomic component gains a reproductive advantage at the expense of the organism as a whole. X-linked segregation distorters kill or incapacitate Y-bearing sperm, thereby gaining a transmission advantage but also reducing male fertility and ...

Heritable strategies for controlling insect vectors of disease

Tags: ,
Burt, A,  Philosophical Transactions of the Royal Society B-Biological Sciences,  369:20130432. 2014.
Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and economic loss in many parts of the world, despite current control efforts, and new complementary approaches to controlling these diseases are needed. One promising class of new interventions ...

Meiotic drive impacts expression and evolution of X-linked genes in stalk-eyed flies

Tags: , , ,
Reinhardt, JAB, C. L.; Paczolt, K. A.; Johns, P. M.; Baker, R. H.; Wilkinson, G. S.,  PLOS Genetics,  10:e1004362. 2014.
Although sex chromosome meiotic drive has been observed in a variety of species for over 50 years, the genes causing drive are only known in a few cases, and none of these cases cause distorted sex-ratios in nature. In stalk-eyed flies (Teleopsis dalmanni), driving X chromosomes ...

Regulatory experience and challenges for the release of GM insects

Tags: , , , , , , , , , ,
Beech, C,  Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety,  9:S71-S76. 2014.
Genetically modified (GM) insects are a potentially valuable new tool for the biological control of insect pests of humans, animals and plants. Considerable progress has been made recently in transfer of GM insects from the laboratory to release and evaluation in the environment. ...

Analysis of segregation distortion and its relationship to hybrid barriers in rice

Tags: , , ,
Reflinur, K, B.; Jang, S. M.; Chu, S. H.; Bordiya, Y.; Akter, M. B.; Lee, J.; Chin, J. H.; Koh, H. J.,  Rice,  7:3. 2014.
Segregation distortion (SD) is a frequently observed occurrence in mapping populations generated from crosses involving divergent genotypes. In the present study, ten genetic linkage maps constructed from reciprocal F-2 and BC1F1 mapping populations derived from the parents ...

Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila: A theoretical exploration of Medea-dependent population suppression

Tags: , ,
Akbari, OSC, C. H.; Marshall, J. M.; Huang, H. X.; Antoshechkin, I.; Hay, B. A.,  ACS Synthetic Biology,  3:915-928. 2014.
Insects act as vectors for diseases of plants, animals, and humans. Replacement of wild insect populations with genetically modified individuals unable to transmit disease provides a potentially self-perpetuating method of disease prevention. Population replacement requires a ...

Multiple sex chromosomes in the light of female meiotic drive in amniote vertebrates

Tags: , , , ,
Pokorna, MA, M.; Kratochvil, L.,  Chromosome Research,  22:35-44. 2014.
It is notable that the occurrence of multiple sex chromosomes differs significantly between major lineages of amniote vertebrates. In this respect, birds are especially conspicuous, as multiple sex chromosomes have not been observed in this lineage so far. On the other hand, in ...

Meiotic drive influences the outcome of sexually antagonistic selection at a linked locus

Tags: , ,
Patten, MM,  Journal of Evolutionary Biology,  27:2360-2370. 2014.
Most meiotic drivers, such as the t-haplotype in Mus and the segregation distorter (SD) in Drosophila, act in a sex-specific manner, gaining a transmission advantage through one sex although suffering only the fitness costs associated with the driver in the other. Their ...

Regulating gene drives

Tags: , ,
Oye, KAE, K.; Appleton, E.; Catteruccia, F.; Church, G.; Kuiken, T.; Lightfoot, S. B. Y.; McNamara, J.; Smidler, A.; Collins, J. P.,  Science,  345:626-628. 2014.
Regulatory gaps must be filled before gene drives could be used in the wild

Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive

Tags:
Okamoto, KWR, M. A.; Gould, F.; Lloyd, A. L.,  PLOS Neglected Tropical Diseases,  8:e2827. 2014.
Introgressing anti-pathogen constructs into wild vector populations could reduce disease transmission. It is generally assumed that such introgression would require linking an anti-pathogen gene with a selfish genetic element or similar technologies. Yet none of the proposed ...

Transmission distortion affecting human noncrossover but not crossover recombination: A hidden source of meiotic drive

Tags: , ,
Odenthal-Hesse, LB, I. L.; Veselis, A.; Jeffreys, A. J.; May, C. A.,  PLOS Genetics,  10:e1004106. 2014.
Author Summary Meiosis is an essential feature of sexual reproduction that maintains chromosome number over generations. This specialised form of cell division creates gametes containing a single copy of each chromosome so that each parent contributes half their genetic ...

Evidence for meiotic drive as an explanation for karyotype changes in fishes

Tags: ,
Molina, WFM, P. A.; Bertollo, L. A. C.; Bidau, C. J.,  Marine Genomics,  15:29-34. 2014.
The process of preferential chromosome segregation during meiosis has been suggested to be responsible for the predominance of certain chromosome types in the karyotypes of mammals, birds and insects. We developed an extensive analysis of the fixation of mono- or bibrachial ...

« First ‹ Previous 1 85 93 94 95 96 97 105 118 Next › Last »